The study of physics and thermal characteristics for in-hospital neutron irradiator (IHNI)

Guotu, Ke; Sun, Ziyong; Feng, Shiping; Liu, Tiancai; Li, Yiguo; Zhou, Yue

doi:10.1016/j.apradiso.2009.03.117

Cited by 32 publications

(17 citation statements)

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“…In case of thermal mode, the results are very close to those obtained in IHNI facility. This facility consists of Graphite as moderator and reflector and Bi as gamma shield (Ke et al, 2009). In RA3 facility, to irradiate a sample, it must be loaded to the thermal column, so its high thermal neutron flux cannot be used for clinical BNCT.…”

Section: Resultsmentioning

confidence: 99%

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MCNP design of thermal and epithermal neutron beam for BNCT at the Isfahan MNSR

Monshizadeh

Kasesaz

Khalafi

et al. 2015

Progress in Nuclear Energy

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Section: Resultsmentioning

confidence: 99%

“…Some of the frequently used moderators which are used in BNCT beam lines are (Miller et al, 2009). c (Ke et al, 2009). d (Kasesaz et al, 2014b).…”

Section: Beam Shaping Assembly Designmentioning

confidence: 92%

MCNP design of thermal and epithermal neutron beam for BNCT at the Isfahan MNSR

Monshizadeh

Kasesaz

Khalafi

et al. 2015

Progress in Nuclear Energy

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“…The source of neutrons was an in-hospital neutron irradiator mark 1 reactor (IHNI-1) (Beijing, China), designed by a member of the Chinese Academy of Engineering, Zhou YongMao and his colleagues [17]. IHNI-1 is exclusively used for boron neutron capture therapy (BNCT) based on a miniature neutron source reactor.…”

Section: Neutron Resources Devicementioning

confidence: 99%

Folate receptor-mediated boron-10 containing carbon nanoparticles as potential delivery vehicles for boron neutron capture therapy of nonfunctional pituitary adenomas

Dai

Cai

Hwang

et al. 2013

Sci. China Life Sci.

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Invasive nonfunctional pituitary adenomas (NFPAs) are difficult to completely resect and often develop tumor recurrence after initial surgery. Currently, no medications are clinically effective in the control of NFPA. Although radiation therapy and radiosurgery are useful to prevent tumor regrowth, they are frequently withheld because of severe complications. Boron neutron capture therapy (BNCT) is a binary radiotherapy that selectively and maximally damages tumor cells without harming the surrounding normal tissue. Folate receptor (FR)-targeted boron-10 containing carbon nanoparticles is a novel boron delivery agent that can be selectively taken up by FR-expressing cells via FR-mediated endocytosis. In this study, FR-targeted boron-10 containing carbon nanoparticles were selectively taken up by NFPAs cells expressing FR but not other types of non-FR expressing pituitary adenomas. After incubation with boron-10 containing carbon nanoparticles and following irradiation with thermal neutrons, the cell viability of NFPAs was significantly decreased, while apoptotic cells were simultaneously increased. However, cells administered the same dose of FR-targeted boron-10 containing carbon nanoparticles without neutron irradiation or received the same neutron irradiation alone did not show significant decrease in cell viability or increase in apoptotic cells. The expression of Bcl-2 was down-regulated and the expression of Bax was up-regulated in NFPAs after treatment with FR-mediated BNCT. In conclusion, FR-targeted boron-10 containing carbon nanoparticles may be an ideal delivery system of boron to NFPAs cells for BNCT. Furthermore, our study also provides a novel insight into therapeutic strategies for invasive NFPA refractory to conventional therapy, while exploring these new applications of BNCT for tumors, especially benign tumors.

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“…In this session, a newly designed dedicated single-purpose reactor will be introduced [24,25] . Based on·modified Miniature Neutron Source Reactor (MNSR) techniques, the IHNI is an undermoderated reactor of pool-tank type with low enriched uranium (LEU) core, and can be installed on the basement floor of the main building or in an independent building.…”

Section: Reactor and Neutron Beammentioning

confidence: 99%