The study of the anti-exudative activity of dezapur on the model of acute pulmonary edema in rats

Abstract

The high anti-exudative action of the test compound has been found in the study of a new substance Dezapur on the model of acute toxic pulmonary edema in rats inducedThe issues of creating new drugs with the anti-inflammatory activity and low side effects are of great current interest. It is known that inflammatory processes accompany groups of diseases that are different by their nature. Pulmonary edema is one of the most urgent problems of modern medicine [2,4]. Mortality from pulmonary edema is 60-70% despite the modern equipment of the best clinics in the world. The etiology of pulmonary edema can be varied. There are several forms of pulmonary edema such as cardiogenic and non-cardiogenic acute lung injury, neurogenic edema and other forms. Acute pulmonary edema rapidly develops and takes a special place by severity of the respiratory function disorders and difficulties in treatment [7,10,11]. This pathology is of great interest for researchers in searching new pathogenetically substantiated methods of treatment. The mechanism of the anti-inflammatory action of NSAIDs is oriented to inhibition of the enzyme activity of cyclooxygenase (COX) existing in a living organism in two isoforms -COX-1 (constitutive) and COX-2 (induced). Each isoform has its own functions: the therapeutic effect occurs through inhibition of the COX-2 activity, and the main side effects appear while inhibiting COX-1. The range of side effects of NSAIDs is rather wide, gastrointestinal complications are the most dangerous. When using NSAIDs one should also consider the possibility of interactions with other drugs [3].The aim of our work was a profound study of the pharmacological action of a new chemical substance under the conditional name of Dezapur, namely identification of its anti-exudative activity on the model of the experimental pulmonary edema in rats.