2016
DOI: 10.1007/s12247-016-9256-7
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The Study of the Influence of Formulation and Process Variables on the Functional Attributes of Simvastatin–Phospholipid Complex

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Cited by 19 publications
(7 citation statements)
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“…Many methods or techniques such as micronization, solid dispersion, cyclodextrin complexation, microemulsion, liposomes, nanoparticles, phospholipid complex, and self-microemulsifying drug delivery system (SMEDDS), etc. have been tried to improve the solubility, dissolution rate and thus oral bioavailability of the drug (4)(5)(6)(7)(8)(9)(10)(11)(12).…”
mentioning
confidence: 99%
“…Many methods or techniques such as micronization, solid dispersion, cyclodextrin complexation, microemulsion, liposomes, nanoparticles, phospholipid complex, and self-microemulsifying drug delivery system (SMEDDS), etc. have been tried to improve the solubility, dissolution rate and thus oral bioavailability of the drug (4)(5)(6)(7)(8)(9)(10)(11)(12).…”
mentioning
confidence: 99%
“…For studying the solubility in solid lipids, accurately weighed EZE (30 mg) was taken in a test tube; the solid lipid was added in increments of 0.5 g, and the test tube was heated in a controlled temperature water bath kept at 80 °C till the clear melt was achieved. By this way, the quantity of solid lipid required to solubilize 30 mg of EZE was estimated [ 39 , 40 ].…”
Section: Methodsmentioning
confidence: 99%
“…The solution is later concentrated and anti-solvent like n-hexane is added. 39 Phospholipid complex will form as a precipitate which is further filtered under vacuum and stored in an air tight amber colored glass container.…”
Section: Salting Out Anti Solvent Precipitation Methodsmentioning
confidence: 99%