The study on the association between Beijing genotype family and drug susceptibility phenotypes of Mycobacterium tuberculosis in Beijing

Liu, Yi; Jiang, Xiaoying; Li, Wensheng; Zhang, Xuxia; Wang, Wei; Li, Chuanyou

doi:10.1038/s41598-017-14119-z

Cited by 21 publications

(28 citation statements)

References 33 publications

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“…And they were identified as the causative agents of tuberculosis in the world. For each families of MTB resistance to rifampicin, the prevalence was analyzed for the selected studies as follows: Beijing nineteen studies [14, 15, 16, 17, 18, 19, 20, 21, 22, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31], LAM ten studies [15, 17, 23, 25, 28, 29, 32, 33, 34, 35], T ten studies [3, 15, 16, 17, 23, 27, 28, 32, 34, 35], EAI eight studies [18, 22, 25, 27, 28, 29, 33, 36], Ural four studies [15, 17, 30, 34] Haarlem five studies [15, 23, 25, 28, 34], CAS four studies [15, 29, 30, 35] and MANU two studies [16, 29]. The proportion of rifampicin resistance varies by the type of regions and strains.…”

Section: Resultsmentioning

confidence: 99%

“…Eigteen studies reported rifampicin resistance Beijing family. Of these studies, nine were conducted in Western Pacific Region, reported 1309 (97.68%) resistance Beijing family [2, 16, 20, 21, 22, 28, 29, 30, 31], three studies were conducted in South-East Asia Region, reported 15 (1.11%) resistance Beijing family [15, 19, 25], two studies were conducted in European Region and identified 14 (1.04%) resistance Beijing family [17, 24] and two studies were conducted in Region of American but only two resistance Beijing family [18, 23]. One study which was conducted in African Region [29] and one study conducted in Eastern-Mediterranean Region did not report a rifampicin resistance Beijing family [30].…”

Section: Resultsmentioning

confidence: 99%

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Resistance of Mycobacterium tuberculosis strains to Rifampicin: A systematic review and meta-analysis

Feyisa

Abdurahman

Jimma

et al. 2019

Heliyon

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IntroductionAntitubercular drug resistance strain is a horrifying barrier to effective TB treatment and prevention. The present study aimed to determine the prevalence and geographical distribution of rifampicin-resistance M. tuberculosis (MTB) strains.MethodsWe searched two electronic databases, PubMed and EMBASE, until 26 March 2017 and updated our search on 27 April 2018 and accessed all prevalence studies of MTB strain and their drug susceptibility patterns to rifampicin. The pooled prevalence estimate was determined using random effects model.ResultsWe identified 23 studies satisfying the inclusion criteria. The proportion of rifampicin resistance strains was diverged depending on the type of strains, country and Regions. The pooled estimate of rifampicin-resistance strains of MTB for the included studies was 4% (95% CI: 3–5%). In subgroup analysis based on World Health Organization (WHO) Regions, the pooled estimate of rifampicin-resistance strains of MTB was 11% (95% CI: 9–13%) with the Western Pacific Region 24%, Europian Region 10%, South-East Asian Region 6%, African Region 3% and Region of American 1%. Beijing family was the most dominant strain resistance to rifampicin with pooled prevalence of 14% (95% CI: 10–18%). The pooled prevalence of other families, i.e. EAI, T, CAS, MANU, Haarlem, LAM and Ural, was ≤2% for each.ConclusionHigh burden of rifampicin resistance MTB strains was identified in the Western Pacific Region. Of these, Beijing family was predominantly resistance to rifampicin in Western Pacific Region and South-East Asian Region and also spread to European Region and Region of American.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Resistance of Mycobacterium tuberculosis strains to Rifampicin: A systematic review and meta-analysis

Feyisa

Abdurahman

Jimma

et al. 2019

Heliyon

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“…Using spoligotyping the global population of MTB can be classified into four main lineages, lineage 1(Indo-Oceanic lineage), lineage 2 (East-Asian lineages, that includes Beijing family), lineage 3 (East African Indian that includes Central Asian Strain, CAS/Delhi family) and lineage 4 (Euro-American family) 5 . Previous studies have demonstrated a relationship between drug resistance and genotype of MTB 6 – 8 , while other studies failed to find an association 9 . The Beijing genotype is reported to have unusual characteristics such as hyper-virulence, higher pathogenicity, a greater ability to overcome immunity afforded by BCG vaccination and frequent association with MDR-TB 10 , 11 .…”

Section: Introductionmentioning

confidence: 95%

Genetic diversity and distribution dynamics of multidrug-resistant Mycobacterium tuberculosis isolates in Nepal

Maharjan

Nakajima

Isoda

et al. 2018

Sci Rep

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Multidrug-resistant tuberculosis (MDR-TB) is an emerging public health problem in Nepal. Despite the implementation of a successful TB control program in Nepal, notifications of MDR-TB are increasing, yet the reasons are unknown. The objective of this study was to understand the genetic diversity and epidemiological characteristics of MDR-Mycobacterium tuberculosis (MTB) isolates in Nepal. We isolated and genotyped 498 MDR-MTB isolates collected from April 2009 to March 2013 and analyzed the patients’ background information. Our results showed that the lineage 2 (Beijing family) was the most predominant lineage (n = 241; 48.4%), followed by lineage 3 (n = 153, 30.7%). Lineage 4 was the third most prevalent (n = 73, 14.5%) followed by lineage 1 (n = 32, 6.4%). The lineages were significantly associated with geographic region, ethnic group, age and sex of patients. The Beijing genotype was found to have an important role in transmitting MDR-TB in Nepal and was significantly associated with the eastern region, mongoloid ethnic group and younger age group. We conclude that early diagnosis and treatment including molecular-epidemiological surveillance of MDR-TB cases will help to control transmission of MDR-TB in Nepal.

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“…Beijing is confronting public health issues in the prevention and control of TB [4, 27]. The association between the prevalence of Beijing genotype strains and their drug resistance status in Beijing is unclear.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Mycobacterium tuberculosis strains in Beijing, China: drug susceptibility phenotypes and Beijing genotype family transmission

Liu

Zhang

et al. 2018

BMC Infect Dis

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BackgroundThe most prevalent strains of Mycobacterium tuberculosis (M.tb) in Beijing belong to the Beijing genotype family. The influence of Beijing genotype prevalence on the development of drug resistance, and the association of infection with Beijing genotype M.tb with population characteristics, in Beijing, however, are still unclear.MethodsIn this retrospective study, 1189 isolates were subjected to drug susceptibility testing (DST) and molecular epidemiological analysis, and differences in the percentage of drug resistance between Beijing and non-Beijing genotype strains were compared. The association between the occurrence of drug resistance and the prevalence of Beijing genotype M.tb was analyzed using statistical methods.ResultsThe Beijing genotype family was the dominant genotype (83.3%) among the 1189 M.tb isolates. Beijing genotype M.tb strains were more likely to spread among males [p = 0.018, OR (95% CI):1.127(1.004–1.264)] and people in the 45–64 age group [p = 0.016, OR (95% CI): 1.438 (1.027–2.015)]. On the contrary, non-Beijing genotype M.tb strains were more probably disseminated among the over 65 [p = 0.005, OR (95% CI):0.653 (0.474–0.9)] and non-resident population [p = 0.035, OR (95% CI):1.185(0.985–1.427)]. DST results showed that 849 (71.4%) strains were fully sensitive to first-line drugs, while 340 (28.6%) strains were resistant to at least one drug, and 9% (107/1189) were MDR-TB. The frequency of INH-resistance among Beijing genotype strains was significantly lower than that among non-Beijing genotype strains (p = 0.032). In addition, the Beijing genotype family readily formed clusters.ConclusionsOur findings indicate that male and middle-aged people were more probably be infected by Beijing genotype M.tb, older people and non-residents were more probably be infected by non-Beijing genotype M.tb. The high percentage of resistance to INH occurring in non-Beijing genotype strains suggested that non-Beijing genotype strains should be given much more interest in Beijing.Electronic supplementary materialThe online version of this article (10.1186/s12879-018-3578-7) contains supplementary material, which is available to authorized users.

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The study on the association between Beijing genotype family and drug susceptibility phenotypes of Mycobacterium tuberculosis in Beijing

Cited by 21 publications

References 33 publications

Resistance of Mycobacterium tuberculosis strains to Rifampicin: A systematic review and meta-analysis

Resistance of Mycobacterium tuberculosis strains to Rifampicin: A systematic review and meta-analysis

Genetic diversity and distribution dynamics of multidrug-resistant Mycobacterium tuberculosis isolates in Nepal

Characterization of Mycobacterium tuberculosis strains in Beijing, China: drug susceptibility phenotypes and Beijing genotype family transmission

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