The study protocol: Neuroendocrinology and (epi-) genetics of female reproductive transition phase mood disorder - an observational, longitudinal study from pregnancy to postpartum

Abstract

Background Postpartum depression is considered to be one of the most common health threats during pregnancy and postpartum, affecting not only the woman herself but also the offspring and the whole family system. Evidence for a conclusive etiopathological model with distinct risk and resilience factors is still broadly lacking. Therefore, the aim of the present study is to investigate numerous health-related markers to obtain greater insight into which biopsychosocial profiles render women more vulnerable to PPD or facilitate a healthy transition from pregnancy to postpartum. Methods The observational, longitudinal study aims to include a total of 288 physically healthy women, aged 20–45 years. A multitude of relevant parameters, of an (epi-) genetic, endocrinological, physiological and psychological nature, will be assessed over a period of 5 months, following the participants from the 3rd trimester until three months postpartum. Discussion The ultimate goal of the present study is to ameliorate mental health care during pregnancy and postpartum, by gaining a better understanding of the underlying biopsychosocial mechanisms that women undergo during the transition from pregnancy to postpartum.

Trajectories of reproductive transition phase mood disorder from pregnancy to postpartum: A Swiss longitudinal study

“…A variety of (epi-)genetic, biological, physiological, and psychological parameters were assessed within the research project; detailed information can be found in the study protocol. 34 The large research project was approved by the Ethics Committee of the Canton of Zurich (KEK-ZH-Nr. 2018–02357) and conducted in accordance with the Declaration of Helsinki.…”

“…During this first lab session, various psychological, biological, and (epi-) genetic parameters were assessed (an overview and more detailed information are provided in the Study Protocol). 34 At the end of the lab appointment, the women were instructed about the follow-up measurements to be taken at home. The second and final lab appointment was scheduled around 12 weeks after giving birth and assessed the same parameters as during pregnancy as well as birth-related information.…”