Abstract:Protein conjugation with the Small Ubiquitin-like Modifier SUMO1 or the related SUMO2/3 drive changes to protein behaviour. Many substrates are found modified by both SUMO1 and SUMO2/3, while others are modified by one or the other. How isoform specificity is directed is poorly understood. Here we examine modification of the catalytic component of the human SUMO Activation Enzyme, SAE2. We find that an acetylated K164-SAE2 analogue preferentially activates SUMO2 in competition with SUMO1, and that K164-SAE2 di… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.