The Synergistic Behavior of Antioxidant Phenolic Compounds Obtained from Winemaking Waste’s Valorization, Increased the Efficacy of a Sunscreen System

Abstract

Grape pomace retains polyphenols in the peels and in the seeds after winemaking, which is indicative of the high valorization potential of this industrial waste. There is strong evidence that phenolics are robust antioxidants and confer photoprotection; thus, it is rational to apply these active compounds from winemaking waste to sunscreens, in order to increase UV protection. Despite the importance of this class of cosmetics to public health, more efficacious strategies are still needed to overcome the problems caused by the photoinstability of some UV filters. The hydroethanolic extract of Vitis vinifera L. grapes was obtained by percolation and then lyophilized. Six formulations were developed: Type I—cosmetic base and UV filters; Type II—cosmetic base and extract; and Type III—cosmetic base, extract and UV filters. Each formulation was prepared in the pHs 5 and 7. The antioxidant activities of the samples were measured by DPPH• and expressed in Trolox® equivalents (TE), and their photostability and in vitro sun protection factor (SPF) were analyzed by diffuse reflectance spectrophotometry. The anti-radical efficiencies observed in the formulations with grape extract were: (II) 590.12 ± 0.01 μmol TE g−1 at pH 5 and 424.51 ± 0.32 μmol TE g−1 at pH 7; (III) 550.88 ± 0.00 μmol TE g−1 at pH 5 and 429.66 ± 0.10 μmol TE g−1, at pH 7, demonstrating that the UV filters, butylmethoxydibenzoyl methane, ethylhexyl methoxycinnamate and ethylhexyl dimethyl 4-aminobenzoic acid had no influence on this effect. The photoprotective efficacy and the photostability of formulation III containing the extract and UV filters at pH 5 suggested that a synergism between the active molecules provided an 81% increase in SPF. Additionally, this was the only sample that maintained a broad spectrum of protection after irradiation. These results confirmed that the grape pomace extract has multifunctional potential for cosmetic use, mainly in sunscreens, granting them superior performance.

Voltammetric Behavior, Flavanol and Anthocyanin Contents, and Antioxidant Capacity of Grape Skins and Seeds during Ripening (Vitis vinifera var. Merlot, Tannat, and Syrah)

“…The non-flavonoids such as stilbenes and phenolic acids are found in the skins [ 6 ]. The synergy between the various classes of polyphenols increases sample efficiency and activity [ 7 ]. Polyphenols protect plants against biotic and abiotic stresses and they are involved in organoleptic and qualitative properties of food and beverages derived from these plants [ 8 ].…”

“…Many studies have reported their biological activities. They have potent antioxidant capacity [ 7 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ]. They may prevent diabetes [ 19 , 20 ], obesity [ 21 , 22 , 23 ], cardiovascular [ 24 , 25 ], and neurodegenerative diseases [ 25 , 26 ].…”

Safety and Photoprotective Efficacy of a Sunscreen System Based on Grape Pomace (Vitis vinifera L.) Phenolics from Winemaking

“…A1. The active compounds of the by-product were extracted by our research group following the methodology of the Brazilian Pharmacopoeia, 5th edition [28] and Hubner and collaborators [16]. The hydroethanolic extract 70% (v/v) was prepared from grape pomace (3.2 kg) dried and pulverized by the percolation process until the drug is exhausted.…”

“…[13,15]. Figure 1 shows the main phenolic groups identified by our research group for a specimen of grape pomace from V. vinifera [16]. The literature attributes the antioxidant activities of V. vinifera to fruit skin, with 90% due to anthocyanins and proanthocyanins and 10% to flavonols, flavanols, and phenolic acids.…”

Effect of Nanoconfinement of Polyphenolic Extract from Grape Pomace into Functionalized Mesoporous Silica on Its Biocompatibility and Radical Scavenging Activity

“…Using a 70% hydroethanolic extract from grape pomace combined with other filters for sunscreen formulations led to the obtaining of a sun protecting factor (SPF) of 76, 2.5 times higher than the formulation without adding grape pomace extract. However, without adding additional sun filters, no SPF protection was achieved [ 42 ].…”