The synergistic effect between interoceptive accuracy and alcohol use disorder status on pain sensitivity

Jakubczyk, Andrzej; Wiśniewski, Paweł; Trucco, Elisa M.; Kobyliński, Paweł; Zaorska, Justyna; Skrzeszewski, Jakub; Suszek, Hubert; Wojnar, Marcin

doi:10.1016/j.addbeh.2020.106607

Cited by 11 publications

(10 citation statements)

References 52 publications

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“…In contrast, among individuals with AUD, the association between pain sensitivity and emotional dysregulation was in the opposite direction (i.e., higher pain sensitivity leads to higher emotional dysregulation; see Figure 3 ). These results extend prior findings demonstrating between-group differences across individuals with AUD and HCs in the association between interoceptive and pain sensitivity [ 37 ].…”

Section: Discussionsupporting

confidence: 89%

“…Participants were asked to make a mark on a 10 cm horizontal line ranging from "no pain at all" to the "worst pain imaginable", reflecting their current experience of physical pain. This measure provided confirmation that individuals with AUD report more overall severe current pain in comparison to HCs (see [37]). Moreover, the current experience of pain was included as a covariate.…”

mentioning

confidence: 57%

“…HCs included 110 adults (40.6 ± 8.1 years of age) that met with a primary care physician for medical advice or a yearly physical examination. Jakubczyk and colleagues [ 37 ] provide an additional description of the sample with respect to sociodemographic information and clinical and alcohol use characteristics. The AUD sample consisted of individuals with severe symptoms of AUD, but the absence of acute withdrawal symptomatology, with an average duration of 49.2 ± 45.1 days abstinent from alcohol prior to completing the study procedures.…”

Section: Methodsmentioning

confidence: 99%

“…[ 36 ], emotional regulation appeared to fully mediate the association between depression severity and pain severity in an AUD sample. Recently, Jakubczyk and colleagues [ 37 ] reported that the association between interoceptive accuracy (i.e., precision in perceiving internal processes measured behaviorally) and pain sensitivity may be moderated by AUD status. Namely, while interoceptive accuracy was associated with lower pain sensitivity among individuals with AUD, the opposite was true among healthy individuals.…”

Section: Introductionmentioning

confidence: 99%

“…Namely, while interoceptive accuracy was associated with lower pain sensitivity among individuals with AUD, the opposite was true among healthy individuals. Given that better interoceptive accuracy is positively associated with emotional regulation [ 37 ], it is plausible that the association between pain sensitivity and emotional regulation could differ across AUD and non-AUD samples.…”

Section: Introductionmentioning

confidence: 99%

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Pain Sensitivity, Negative Affect, and Alcohol Use Disorder Status: A Moderated Mediation Study of Emotion Dysregulation

Kopera

Trucco

Suszek

et al. 2021

JCM

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Previous work suggests that the association between pain and emotional processes among individuals with alcohol use disorder (AUD) may differ from healthy controls. This study investigates whether pain sensitivity mediates the association between negative affect and emotional dysregulation and whether this association differs across AUD status using moderated mediation. The sample included 165 individuals diagnosed with AUD and 110 healthy controls. Of interest was pain sensitivity, as assessed with the Pain Sensitivity Questionnaire, negative affect, as assessed with the Beck Depression Inventory, and emotional dysregulation, as assessed with the Difficulties in Emotional regulation Scale. Age, biological sex, and current pain severity were included as covariates. The results support a moderated partial mediation model that explained 44% of the variance in emotional dysregulation. The findings indicate that negative affect is related to higher pain sensitivity across groups. Moreover, pain sensitivity partially mediated the association between negative affect and emotional dysregulation, but in opposite directions depending on AUD status. Among healthy controls, greater pain sensitivity was related to better emotional regulation, while greater pain sensitivity led to greater emotional dysregulation among individuals with AUD. The potential parallels in the underlying neurobiological mechanisms of emotionality, pain, and AUD suggest that interventions targeting pain may improve adaptive affect regulation skills, which in turn could reduce negative affect and its effect on pain sensitivity among individuals with AUD.

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Section: Discussionsupporting

confidence: 89%

mentioning

confidence: 57%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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