The synthesis and antimicrobial activity of isatin-3-(4'-hydroxy) benzoylhydrazone

Synthesis and characterization of N, N′-bis (isatin) diamino zirconium (IV) complexes

“…1 and 2, respectively. The spectra of the ligands should contain stretching bands for the azomethine group ((>C=Ngroup), C-N and C=O bonds at 1625-1582 cm -1 (Singh et al, 2012), 1020-1250 cm -1 (Uddin et al, 2012) and 1730-1750 cm -1 (Konstantinovic et al, 2015) regions, respectively. The vibrational frequency at 3150-3300 cm -1 (Ade et al, 2012) and 1460 cm -1 (Konstantinović et al, 2015) correspond stretching and bending vibration of N-H bond.…”

“…1H-indole-2,3-dione, commonly known as Isatin, is one of the leading class of oxo-derivative indoles with synthetic versatility. It is used as building entity of a broad range of alkaloids, drugs, pesticides and dyes (Konstantinovic et al, 2015). Isatin and its derivatives possess antimicrobial, antiviral, anticonvulsive, antitumor, anti-HIV, anti-inflammatory and antimycobacterial activity (Mathur and Nain, 2014).…”

“…synthesized N, N'-Bis (indol -2-oxo-3-ylidene)-1, 2-Diaminoethane and N, N'-Bis (indol -2-oxo-3-ylidene)-1, 3-Diaminopropane Schiff base complexes of tellurium(IV) and found 92% and 91% inhibiting activity against Mycobacterium tuberculosis compared to Rifampin standard. Konstantinovic et al (2015) synthesized of isatin-3-(4'-hydroxy) benzoylhydrazone and observed their inhibiting activity against the Gram-positive bacteria Enterococcus faecalis and yeast Candida albicans in the concentration range of 25-50 μg-cm. Ade et al (2012) synthesized Dichloro-[4-Chloro-2-(2-oxo-1, 2-dihydroindol-3-ylidene amino)-benzoic acid] (ACBAI) aquo complexes of Ti(IV), Zr(IV) and Cd(II) chloride and proposed uninegative tridentate nature of (ACBAI) ligand.…”