The synthesis, characterization and biological evaluation of a stable phosphorus ylide and an imidazole as novel compounds

Abstract

ABSTRACT. A convenient one pot synthesis of two novel compounds including a stable phosphorus ylide and an imidazole from electron-poor acetylenes in fairly good yields by the condensation of triphenylphosphine and acetylene derivatives, in the presence of dimethyl thiourea from the 1:1:1 addition reactions is described. The structures of the synthesized compounds were characterized by IR, 1 H-NMR, 13 C-NMR and elemental analysis. The newly synthesized compounds were screened for antimicrobial on Staphylococcus aureus, Bacillus sublitis, Escherichia coli and Pseudomonas aeruginosa and antifungal activities on Candida albicans, patient isolate Candida glabrata and Candida krusei. The results showed that these compounds have activity against all the tested bacteria and fungi with a sufficient minimum inhibitory concentration.

Review of pharmacological effects of imidazole derivatives

“…Compounds had the activity comparable with fluconazole against C. albicans. However, these compounds were not superior to the reference preparations used against other fungi [10].…”

Phosphonium salts and P-ylides

“…7). 262,263 The reactions of nucleophilic active phosphacumulene, phosphaallene, and stable phosphonium ylides with different substrates were investigated by Said, Zeid and co-workers (Fig. 7).…”