The synthesis of translucent polymer nanolatexes via microemulsion polymerization

Smeets, Niels M. B.; McKenna, Timothy F. L.

doi:10.1016/j.jcis.2012.06.012

Cited by 8 publications

(5 citation statements)

References 41 publications

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“…As shown in Figure 1a, the formation of microemulsion was confirmed at 4:6 to 6:4 composition ratios of TPGS to GCC. The area of formation of translucent microemulsion was the largest when the composition ratio of GCC and TPGS was approximately 5:5 [57][58][59]. Therefore, an optimized lipid complex for microemulsion formation was obtained with a TPGS to GCC was 5:5.…”

Section: Ternary Phase Diagrammentioning

confidence: 94%

Nanoporous Silica Entrapped Lipid-Drug Complexes for the Solubilization and Absorption Enhancement of Poorly Soluble Drugs

2021

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This study aims to examine the contribution of nanoporous silica entrapped lipid-drug complexes (NSCs) in improving the solubility and bioavailability of dutasteride (DUT). An NSC was loaded with DUT (dissolved in lipids) and dispersed at a nanoscale level using an entrapment technique. NSC microemulsion formation was confirmed using a ternary phase diagram, while the presence of DUT and lipid entrapment in NSC was confirmed using scanning electron microscopy. Differential scanning calorimetry and X-ray diffraction revealed the amorphous properties of NSC. The prepared all NSC had excellent flowability and enhanced DUT solubility but showed no significant difference in drug content homogeneity. An increase in the lipid content of NSC led to an increase in the DUT solubility. Further the NSC were formulated as tablets using D-α tocopheryl polyethylene glycol 1000 succinate, glyceryl caprylate/caprate, and Neusilin®. The NSC tablets showed a high dissolution rate of 99.6% at 30 min. Furthermore, NSC stored for 4 weeks at 60 °C was stable during dissolution testing. Pharmacokinetic studies performed in beagle dogs revealed enhanced DUT bioavailability when administered as NSC tablets. NSC can be used as a platform to develop methods to overcome the technical and commercial limitations of lipid-based preparations of poorly soluble drugs.

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Section: Ternary Phase Diagrammentioning

confidence: 94%

Nanoporous Silica Entrapped Lipid-Drug Complexes for the Solubilization and Absorption Enhancement of Poorly Soluble Drugs

2021

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“…Bulk NBs can also be generated by mixing or shearing of the flow of a gas-liquid mixture. [173][174][175] Based on Bernoulli's principle, and similar dependent on the duration of the agitation step. 176 NBs are generated using a blade positioned within a chamber, which cuts macro-bubbles entrained in the liquid to MBs/NBs.…”

Section: Mixing or Shearing Methodsmentioning

confidence: 99%

Stimuli-responsive nanobubbles for biomedical applications

et al. 2021

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“…The NHAWP was synthesized by the inverse microemulsion polymerization method [ 25 ]. The synthesis procedure is shown in figure 3 and the detailed procedures are as follows: first, 100 g distilled water was added into a beaker.…”

Section: Methodsmentioning

confidence: 99%

A novel hydrophobically associating water-soluble polymer used as constant rheology agent for cement slurry

Liu

et al. 2022

R. Soc. open sci.

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During the process of well cementing in deep water, the cement slurry experiences a wide range of temperature variation from low temperature at seabed to high temperature in downhole. The elevated temperature affects the rheology of cement slurry. The change of rheology of cement slurry could influence the safety of cementing operation. The aim of this paper is to develop a new kind of hydrophobically associating water-soluble polymer (NHAWP) as an additive to prepare a constant rheology oil well cement slurry, which can be used at temperature range from 4°C to 90°C. The acrylamide, 2-acrylamide-2-methylpropionic acid and stearyl methylacrylate were applied to synthesize the NHAWP by the inverse microemulsion polymerization. Test results indicate that the critical association temperature of NHAWP is 45°C. The critical association temperature is independent of NHAWP concentration, salt concentration and alkalinity of solution. When the temperature is below 45°C, NHAWP shows little influence on the viscosity of solution. When the temperature is above 45°C, the NHAWP forms spatial network structure by intermolecular hydrophobic association and thus increases the viscosity of solution significantly. The NHAWP also displays good thermal stability and excellent salt and alkali resistance properties. In addition, the NHAWP shows nearly no negative influence on the basic properties of cement slurry, which indicates that the NHAWP can be used as a constant rheology agent to prepare a cement slurry with constant rheology in the temperature range of 4°C to 90°C.

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The synthesis of translucent polymer nanolatexes via microemulsion polymerization

Cited by 8 publications

References 41 publications

Nanoporous Silica Entrapped Lipid-Drug Complexes for the Solubilization and Absorption Enhancement of Poorly Soluble Drugs

Nanoporous Silica Entrapped Lipid-Drug Complexes for the Solubilization and Absorption Enhancement of Poorly Soluble Drugs

Stimuli-responsive nanobubbles for biomedical applications

A novel hydrophobically associating water-soluble polymer used as constant rheology agent for cement slurry

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