Computer simulation of the stretch forming process of the with different anisotropy of properties in the software package PAM-STAMP 2G was implemented in the work. The design of the multivariate experiment was made to analyze the effect of the anisotropy of the mechanical properties over the final polythickness of the skin after stretch forming. The regression analysis of the results was implemented after simulation, besides a mathematical model of polythickness dependence on the anisotropy of the properties was formulated. The optimal combination of Lankford coefficients, ultimate strength, yield strength and uniform elongation that minimizes polythickness of the finished skin was established.