The Systemic Lupus International Collaborating Clinics (SLICC) damage index: A systematic literature review

Sutton, Emily; Davidson, Julie; Bruce, Ian N.

doi:10.1016/j.semarthrit.2013.05.003

Cited by 135 publications

(112 citation statements)

References 35 publications

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“…значность оценки гормональной терапии, которая может быть основана на регистрации различных показателей, включая «длительность применения», «кумулятивную дозу» или «среднесуточную дозу» [13,14]. В недавно про-веденном исследовании пациентов Хопкинсовской ко-горты S. Sawah и соавт.…”

Section: таблицаunclassified

“…В этом исследовании было также уста-новлено, что «стероид-независимые» повреждения дос-таточно часто встречаются на ранней стадии болезни и их появление можно объяснить высокой активностью СКВ и развитием аутоиммунного воспаления различ-ных тканей с последующим повреждением органа. Клю-чевым вопросом для более точного прогнозирования развития повреждения при назначении ГК является не-однозначность оценки гормональной терапии: «дли-тельность применения», «кумулятивная доза» или «сре-днесуточная доза» [13,14]. Изучению ИП посвящены работы и наших ученых М.М.…”

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Irreversible organ damages in a cohort of patients with systemic lupus erythematosus (RENAISSANCE)

Асеева¹,

Соловьев²,

Клюквина³

et al. 2016

rsp

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Section: таблицаunclassified

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Irreversible organ damages in a cohort of patients with systemic lupus erythematosus (RENAISSANCE)

Асеева¹,

Соловьев²,

Клюквина³

et al. 2016

rsp

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“…cataract or osteoporosis), or long term use of immune suppression (e.g. infertility or malignancies) [103]. The biological mechanism(s) behind a correlation between suPAR and SDI is thus not obvious and needs considerable attention in future studies.…”

Section: Potential Roles Of Supar In Sle Pathogenesismentioning

confidence: 99%

Soluble urokinase plasminogen activator receptor—A valuable biomarker in systemic lupus erythematosus?

Enocsson¹,

Sjöwall²,

Wetterö³

2015

Clinica Chimica Acta

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The expression of uPAR is mainly regulated by growth factors and pro-inflammatory cytokines like basic fibroblast growth factor, epidermal growth factor, tumor necrosis factor, interleukin ( suPAR as a clinical marker of inflammation and organ damagePlasma membrane expression of uPAR as well as the levels of circulating suPAR have been investigated in relation to a broad range of conditions and suPAR has been referred to as a "molecular crystal ball" due to its prognostic value in diseases like tuberculosis, HIV, sepsis and cancer [2,6,13,26,58,59]. Further, it has been reported that it reflects overall immune activation and systemic inflammation [2]. suPAR has also emerged as a potential biomarker of fibrosis in chronic liver diseases of diverse etiology [10,11,[60][61][62].Recently, suPAR attracted significant attention in primary focal segmental glomerulosclerosis (FSGS). data from this pilot study revealed significantly higher suPAR levels among patients with moderately or highly elevated SDI after study inclusion, compared to patients without SDI increase (Figure 2).Furthermore, there were higher death rates among patients in the two groups with SDI increase (Figure 2). However, it is well known that present organ damage predicts further organ damage [17,100], and thus, adjustment for SDI at baseline should be performed to reduce the risk of bias. A stepwise linear multiple regression analysis was therefore performed to evaluate the impact of suPAR on future SDI increase. After adjusting for age, sex and SDI at study inclusion, we found suPAR levels to have a significant impact on future SDI increase (p = 0.005, standardized β = 0.20) whereas SDI at study inclusion was excluded from the model. Since recent studies have revealed an inverse correlation between serum suPAR and glomerular filtration [67,68,96], we also included estimated glomerular filtration (eGFR) (calculated by the 4-variable Modification of Diet in Renal Disease StudyGroup formula [101]) in the analysis, but eGFR was not retained in the model. From these results, we suggest that suPAR can actually predict organ damage independent of present SDI score or eGFR, but that a prospective study examining the association between suPAR levels at the time of diagnosis with future SDI would be preferable.In line with these findings, elevated suPAR levels have previously been demonstrated to associate with the risk of developing cancer, cardiovascular disease and type 2 diabetes later in life in the general population [7]. Importantly, these associations were independent of CRP, which is known for its predictive value in cardiovascular disease [7,102].7 Potential roles of suPAR in SLE pathogenesisAssessment of circulating suPAR levels at the clinical laboratory could possibly become a future way to estimate organ damage in SLE, and suPAR would be an even more appealing biomarker candidate if the levels could be mechanistically linked to the disease. The pathogenesis of SLE is notoriously complex and not fully understood, but includes disturbances in t...

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“…Повреждение внутренних органов определяли с помо-щью индекса повреждения SLICC/ACR (Systemic Lupus International Collaborative Clinics/ACR) [16], который явля-ется важным предиктором летальности и независимым по-казателем исхода [17]. Тяжесть повреждения органов оцени-вали ретроспективно на основании анализа клинических данных.…”

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The clinical course and standard therapy of systemic lupus erythematosus in the Russian Federation

Насонов¹,

Соловьев²,

Лила³

2016

RJTAO

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Данные об особенностях клинического течения и лечения такого тяжелого заболевания, как системная красная волчанка (СКВ), в России практически отсутствуют. Цель исследования ESSENCE -оценка клинической картины заболевания и его лечения у взрослых пациентов с активной СКВ в го-родах трех постсоветских государств (Россия, Украина и Казахстан).Материал и методы. Настоящая публикация касается российских пациентов. Изучены данные (истории болезни) 232 пациентов, которые наблюдались в 6 центрах (Москва, Санкт-Петербург, Воронеж, Екатеринбург, Курск, Ярославль

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The Systemic Lupus International Collaborating Clinics (SLICC) damage index: A systematic literature review

Cited by 135 publications

References 35 publications

Irreversible organ damages in a cohort of patients with systemic lupus erythematosus (RENAISSANCE)

Irreversible organ damages in a cohort of patients with systemic lupus erythematosus (RENAISSANCE)

Soluble urokinase plasminogen activator receptor—A valuable biomarker in systemic lupus erythematosus?

The clinical course and standard therapy of systemic lupus erythematosus in the Russian Federation

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