The T cell factor, pangolin, from Litopenaeus vannamei play a positive role in the immune responses against white spot syndrome virus infection

Zhu, Lulu; Zhang, Shuang; Hou, Cuihong; Liang, Xin; Dehwah, Mustafa Abdo Saif; Tan, Beiping; Shi, Lili

doi:10.1016/j.dci.2021.104041

Cited by 9 publications

(7 citation statements)

References 45 publications

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Section: Discussionsupporting

confidence: 93%

“…RNAi experiments revealed that LvTcf knockdown resulted in greater WSSV proliferation (Figures 1C, D), suggesting that the former plays a protective role against WSSV infection. A recent research found that two isoforms of LvPangolin, LvPangolin1 (LvTcf in this work) and LvPangolin2, had antiviral properties against WSSV, which is compatible with our findings (55). Wnt/b-catenin/TCF signaling pathway-mediated responses to bacterial and viral infections have been the subject of extensive study, highlighting the cascade's roles in orchestrating phagocytosis, antimicrobial or interferon defense, as well as inflammatory cytokine production (56)(57)(58).…”

Section: Discussionsupporting

confidence: 91%

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Phosphorylation of Shrimp Tcf by a Viral Protein Kinase WSV083 Suppresses Its Antiviral Effect

et al. 2021

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Nuclear DNA-binding TCF proteins, which act as the main downstream effectors of Wnt signaling, are essential for the regulation of cell fate and innate immunity. However, their role during viral infection in shrimp remains unknown. Herein, we demonstrated that Litopenaeus vannamei TCF (LvTcf) acts independently of Lvβ-catenin to promote interferon-like protein LvVago1 production, thus mounting the response to WSSV infection. Further, we observed that WSV083, a WSSV serine/threonine protein kinase, bound to LvTcf and phosphorylated it. Phosphorylated LvTcf was then recognized and degraded via the ubiquitin-proteasome pathway. Moreover, mass spectrometry analyses indicated that the T39 and T104 residues of LvTcf were target sites phosphorylated by WSV083. Point mutation analyses suggested that additional sites of LvTcf may undergo phosphorylation via WSV083. Taken together, the current work provides valuable insights into host immunity and viral pathogenesis. LvTcf is not only a modulator of shrimp innate immunity but is also an important target for WSSV immune evasion. Thus, the current findings will help improve disease control in shrimps.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 91%

Phosphorylation of Shrimp Tcf by a Viral Protein Kinase WSV083 Suppresses Its Antiviral Effect

et al. 2021

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“…Aquaculture practices are responsible for approximately 75% of the world’s shrimp production, and the predominant species used are black tiger shrimp, P. monodon and white Pacific shrimp, P. vannamei [ 13 , 14 ]. In the past 20 years, shrimp diseases have caused critical economic losses that seriously threaten farming practices, of which white spot syndrome (WSS) is the deadliest viral disease caused by white spot syndrome virus (WSSV) [ 15 ]. WSSV causes up to 80–100% mortality of infected shrimp within 5–10 days, thus leading to great economic loss [ 16 ]; the total economic loss from this disease is estimated to be approximately 8–15 billion USD, and this continues to increase by 1 billion USD (10% of global shrimp production) annually [ 17 , 18 ].…”

Section: Dna Viral Diseasesmentioning

confidence: 99%

Viral Shrimp Diseases Listed by the OIE: A Review

Lee

Choi

et al. 2022

Viruses

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Shrimp is one of the most valuable aquaculture species globally, and the most internationally traded seafood product. Consequently, shrimp aquaculture practices have received increasing attention due to their high value and levels of demand, and this has contributed to economic growth in many developing countries. The global production of shrimp reached approximately 6.5 million t in 2019 and the shrimp aquaculture industry has consequently become a large-scale operation. However, the expansion of shrimp aquaculture has also been accompanied by various disease outbreaks, leading to large losses in shrimp production. Among the diseases, there are various viral diseases which can cause serious damage when compared to bacterial and fungi-based illness. In addition, new viral diseases occur rapidly, and existing diseases can evolve into new types. To address this, the review presented here will provide information on the DNA and RNA of shrimp viral diseases that have been designated by the World Organization for Animal Health and identify the latest shrimp disease trends.

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“…Due to the presence of four TCF/LEF genes in the genome of vertebrates, it has been assumed that these originated from a single TCF gene ancestor through the two rounds of whole‐genome duplications (2R WGD) that occurred at the base of vertebrate evolution (Aase‐Remedios & Ferrier, 2021 ; Holland & Ocampo Daza, 2018 ; Lamb, 2021 ). However, this hypothesis is currently based only on phylogenetic analyses that include a limited number of gnathostome species (Klingel et al., 2012 ; Zhu et al., 2021 ). In this study, we undertake an in silico comparative study of TCF gene structure across deuterostomes, with a focus on chordates and the invertebrate–vertebrate transition, using molecular phylogeny and synteny analyses to clarify orthology relationships within this gene family.…”

Section: Introductionmentioning

confidence: 99%

Evolutionary diversification of the canonical Wnt signaling effector TCF/LEF in chordates

et al. 2022

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Wnt signaling is essential during animal development and regeneration, but also plays an important role in diseases such as cancer and diabetes. The canonical Wnt signaling pathway is one of the most conserved signaling cascades in the animal kingdom, with the T‐cell factor/lymphoid enhancer factor (TCF/LEF) proteins being the major mediators of Wnt/β‐catenin‐regulated gene expression. In comparison with invertebrates, vertebrates possess a high diversity of TCF/LEF family genes, implicating this as a possible key change to Wnt signaling at the evolutionary origin of vertebrates. However, the precise nature of this diversification is only poorly understood. The aim of this study is to clarify orthology, paralogy, and isoform relationships within the TCF/LEF gene family within chordates via in silico comparative study of TCF/LEF gene structure, molecular phylogeny, and gene synteny. Our results support the notion that the four TCF/LEF paralog subfamilies in jawed vertebrates (gnathostomes) evolved via the two rounds of whole‐genome duplications that occurred during early vertebrate evolution. Importantly, gene structure comparisons and synteny analysis of jawless vertebrate (cyclostome) TCFs suggest that a TCF7L2‐like form of gene structure is a close proxy for the ancestral vertebrate structure. In conclusion, we propose a detailed evolutionary path based on a new pre‐whole‐genome duplication vertebrate TCF gene model. This ancestor gene model highlights the chordate and vertebrate innovations of TCF/LEF gene structure, providing the foundation for understanding the role of Wnt/β‐catenin signaling in vertebrate evolution.

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The T cell factor, pangolin, from Litopenaeus vannamei play a positive role in the immune responses against white spot syndrome virus infection

Cited by 9 publications

References 45 publications

Phosphorylation of Shrimp Tcf by a Viral Protein Kinase WSV083 Suppresses Its Antiviral Effect

Phosphorylation of Shrimp Tcf by a Viral Protein Kinase WSV083 Suppresses Its Antiviral Effect

Viral Shrimp Diseases Listed by the OIE: A Review

Evolutionary diversification of the canonical Wnt signaling effector TCF/LEF in chordates

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