The Taxane Diterpenoids

Kingston, David G. I.; Molinero, Anthony A.; Rimoldi, John M.

doi:10.1007/978-3-7091-9242-9_1

Cited by 65 publications

(19 citation statements)

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“…This partially accounted for the immunocytochemical and SEM detection of taxanes on cell walls. At least six xylosyl derivatives of paclitaxe) were already known (Kingston et al, 1993). After solvent extraction of taxanes~gold-labelled antibodies reaffirmed the occurrence of residual covalently bound laxanes on cell walls.…”

Section: Taxane Yields From Cell Suspensionsmentioning

confidence: 90%

“…IO-Deacetyl derivatives were already recovered bound to xylose, viz. 7-xylosyl-IO...deacetylpaclitaxel, 7-(P-xylosyl)-IO-deacetylcephaIomannine (Kingston et al, 1993).…”

Section: Taxane Yields From Cell Suspensionsmentioning

confidence: 99%

“…Plants produce over 23,000 individual isoprenoids that comprise hornlones, defence agents, visual piglnents, Inenlbrane constituents, nluting pheroillooes, photoprotective agents, components of signal transduction net\\1orks, and llseful anticancer drugs (Sacchettini nnd Poulter, 1997). Between March 1992 to September 1994, 1() 1 new taxoids (taxane diterpenoids) were discovered~bringing the total to nearly 300 cOlnpounds (Appendino, 1995;Kingston et a/., 1993). Conifers were designated of high interest by the National Cancer Institute survey (Barclay and Perdue, 1976) as having significant anticancer activity~Conifers also offer cOlnplications for nletabolic engineering 110t always found in sitnpler and more recently evolved plants such as Arabic/(J!Jsis.…”

Section: Introductionmentioning

confidence: 99%

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Metabolic Engineering of Plant Cells in a Space Environment

Durzan

2000

Biotechnology and Genetic Engineering Reviews

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Section: Taxane Yields From Cell Suspensionsmentioning

confidence: 90%

“…IO-Deacetyl derivatives were already recovered bound to xylose, viz. 7-xylosyl-IO...deacetylpaclitaxel, 7-(P-xylosyl)-IO-deacetylcephaIomannine (Kingston et al, 1993).…”

Section: Taxane Yields From Cell Suspensionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Metabolic Engineering of Plant Cells in a Space Environment

Durzan

2000

Biotechnology and Genetic Engineering Reviews

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“…Paclitaxel was obtained from T. brevifolia bark in 0.07 % yield and it required cumbersome purification from the other related taxanes. It is estimated that about 9000 kg of yew bark (the equivalent of about 3000 trees) are needed to produce 1 kg of purified paclitaxel (41,42). The development of a semi-synthetic process for the production of paclitaxel from baccatin III 37 (paclitaxel without the C-13 side-chain) or 10-deacetyl-baccatin III 38 (10-DAB, paclitaxel without the C-13 side-chain and the C-10 acetate) and C- such as extracts of needles, shoots and young Taxus cultivars (43).…”

Section: Microbial Hydroxylation Of Pleuromutilin or Mutilinmentioning

confidence: 99%

Biocatalytic Synthesis of Chiral Pharmaceutical Intermediates

Patel

2005

ChemInform

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SummaryThe production of single enantiomers of drug intermediates has become increasingly important in the pharmaceutical industry. Chiral intermediates and fine chemicals are in high demand from both the pharmaceutical and agrochemical industries for the preparation of bulk drug substances and agricultural products. The enormous potential of microorganisms and enzymes for the transformation of synthetic chemicals with high chemo-, regio-and enantioselectivities has been demonstrated. In this article, biocatalytic processes are described for the synthesis of chiral pharmaceutical intermediates.

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“…The species of Taxus genus are noted due to their anticancer properties of taxane diterpenoids, mainly paclitaxel [1,2]. Nowadays, there is a growing interest in other groups of secondary metabolites found in Taxus species, including lignans with a considerable pharmacological and hence clinical potential.…”

Section: Introductionmentioning

confidence: 99%

Identification and quantitative determination of pinoresinol in Taxus ×media Rehder needles, cell suspension and shoot cultures

et al. 2015

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The aim of our study was to investigate the presence and quantitative contents of lignans in the tissues of Taxus ×media. The presence of the lignans: pinoresinol, matairesinol and secoisolariciresinol was assessed in needles, shoots cultures and suspension culture. Pinoresinol was the only lignan found in the tissue of T. ×media. The total pinoresinol content in the needles and in the shoots was 1.24 mg/g dry weight (dw) and 0.69 mg/g dw, respectively. Most of the pinoresinol identified was appeared glycosidically bound. In needles, the amount of glycosidically bound pinoresinol (0.81 mg/g dw) was about twice as high as that of free pinoresinol (0.43 mg/g dw). The content of free and glycosidically bound pinoresinol showed the level of 0.18 mg/g dw and 0.51 mg/g dw, respectively in the in vitro shoot cultures. In the cell culture, no pinoresinol was found.

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The Taxane Diterpenoids

Cited by 65 publications

References 0 publications

Metabolic Engineering of Plant Cells in a Space Environment

Metabolic Engineering of Plant Cells in a Space Environment

Biocatalytic Synthesis of Chiral Pharmaceutical Intermediates

Identification and quantitative determination of pinoresinol in Taxus ×media Rehder needles, cell suspension and shoot cultures

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