The terahertz electromagnetically induced transparency-like metamaterials for sensitive biosensors in the detection of cancer cells

Yan, Xin; Yang, Maosheng; Zhang, Zhang; Liu, Liang; Wei, Dequan; Wang, Meng; Zhang, Mengjin; Wang, Tao; Liu, Longhai; Xie, Jianhua; Yao, Jianquan

doi:10.1016/j.bios.2018.11.014

Cited by 289 publications

(127 citation statements)

References 30 publications

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“…2020, 8, 1900721 Figure 6. [96] with relevant dimensions: p = 50 µm, w = 44 µm, t = 25 µm, d = 6 µm, g = 4 µm, s = 28 µm (left). [70].…”

Section: Wwwadvopticalmatdementioning

confidence: 99%

“…a) Comparison between visible (top) and THz (bottom) images of different samples of skin tissue studied in ref. [96] Copyright 2019, Elsevier. The normal tissue is marked with a dashed boundary while the diseased tissue is marked by a solid boundary.…”

Section: Wwwadvopticalmatdementioning

confidence: 99%

“…[96] where the authors designed a metasurface sensor based on symmetry-breaking double SRRs to perform oral cancer cells detection (see the scheme in the left panel of Figure 6b). This is the case of ref.…”

Section: Wwwadvopticalmatdementioning

confidence: 99%

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Terahertz Sensing Based on Metasurfaces

Beruete

Jáuregui-López

2019

Advanced Optical Materials

281

113

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The terahertz (THz) band has very attractive characteristics for sensing and biosensing applications, due to some interesting features such as being a non‐ionizing radiation, very sensitive to weak interactions, thus, complementing typical spectroscopy systems in the infrared. However, a fundamental drawback is its relatively long wavelength (10–1000 µm) which makes it blind to small features, hindering seriously both thin‐film and biological sensing. Recently, new ways to overcome this limitation have become possible thanks to the advent of metasurfaces. These artificial structures are planar screens usually made of periodic metallic resonators and whose electromagnetic response can be controlled at will by design. This design freedom allows metasurfaces to surpass the restrictions of classical THz spectroscopy, by creating fine details comparable to the size of the thin films or microorganisms under test. The strong field concentration near these small metasurface details at resonance makes them highly sensitive to tiny variations in the nearby environment, allowing for an enhanced detection more accurate than classical THz spectroscopy. The main advances in THz metasurface sensors from a historical as well as application‐oriented perspective are summarized. The focus is put mainly on thin‐film and biological sensors, with an aim to cover the most recent advances in the topic.

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“…2020, 8, 1900721 Figure 6. [96] with relevant dimensions: p = 50 µm, w = 44 µm, t = 25 µm, d = 6 µm, g = 4 µm, s = 28 µm (left). [70].…”

Section: Wwwadvopticalmatdementioning

confidence: 99%

Section: Wwwadvopticalmatdementioning

confidence: 99%

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Terahertz Sensing Based on Metasurfaces

Beruete

Jáuregui-López

2019

Advanced Optical Materials

281

113

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“…Hence we have made the scope of this review paper to metasurface biosensing at the molecular and cellular levels with a focus on results that have appeared after the first introduction of the metasurface concept [8]. This section covers metasurface biosensors developed and applied for the targeted detection of antibodies and proteins [127][128][129][130][131][132][133][134][135][136], DNAs [138][139][140][141][142][143], cells [141][142][143][144][145], and cancer biomarkers [146][147][148][149]. Table 1 summarizes the performance of different metasurface Box 2 Performance factors of metasurface biosensors…”

Section: Biosensingmentioning

confidence: 99%

Metasurfaces for biomedical applications: imaging and sensing from a nanophotonics perspective

et al. 2020

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Metasurface is a recently developed nanophotonics concept to manipulate the properties of light by replacing conventional bulky optical components with ultrathin (more than 104 times thinner) flat optical components. Since the first demonstration of metasurfaces in 2011, they have attracted tremendous interest in the consumer optics and electronics industries. Recently, metasurface-empowered novel bioimaging and biosensing tools have emerged and been reported. Given the recent advances in metasurfaces in biomedical engineering, this review article covers the state of the art for this technology and provides a comprehensive interdisciplinary perspective on this field. The topics that we have covered include metasurfaces for chiral imaging, endoscopic optical coherence tomography, fluorescent imaging, super-resolution imaging, magnetic resonance imaging, quantitative phase imaging, sensing of antibodies, proteins, DNAs, cells, and cancer biomarkers. Future directions are discussed in twofold: application-specific biomedical metasurfaces and bioinspired metasurface devices. Perspectives on challenges and opportunities of metasurfaces, biophotonics, and translational biomedical devices are also provided. The objective of this review article is to inform and stimulate interdisciplinary research: firstly, by introducing the metasurface concept to the biomedical community; and secondly by assisting the metasurface community to understand the needs and realize the opportunities in the medical fields. In addition, this article provides two knowledge boxes describing the design process of a metasurface lens and the performance matrix of a biosensor, which serve as a “crash-course” introduction to those new to both fields.

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“…By efficiently coupling and confining the free-space terahertz radiations to a small (usually subwavelength) region, a terahertz antenna can greatly enhance the localized near fields. Therefore, terahertz antennas have been widely used in a diverse range of applications including biosensing [11][12][13][14][15][16] and detection [17,18]. An important figure of merit for these terahertz antennas is the near-field enhancement, which is defined as the ratio of the near-field electric field intensity and the electric field intensity of the incidence [19].…”

Section: Introductionmentioning

confidence: 99%

Large Near-Field Enhancement in Terahertz Antennas by Using Hyperbolic Metamaterials with Hole Arrays

Cheng

Chen

et al. 2019

Applied Sciences

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Terahertz antennas can greatly enhance the near fields and enable strong light–matter interactions, and thus have been widely used in applications such as terahertz sensing and detection. Here we propose a novel approach to further enhance the near fields in terahertz antennas. We show that by sandwiching hyperbolic metamaterials that are composed of InSb and SiO 2 multilayer and that are dressed with hole arrays, between a terahertz dipole antenna and the substrate, the near-field electric field intensities in the antenna can be further enhanced by more than three times. Simulations reveal that this enhancement originates from the doubly enhanced in-plane electric field component and the significantly enhanced out-of-plane electric field component. We expect this work will advance the design of terahertz antennas that are widely used in sensors and detectors.

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The terahertz electromagnetically induced transparency-like metamaterials for sensitive biosensors in the detection of cancer cells

Cited by 289 publications

References 30 publications

Terahertz Sensing Based on Metasurfaces

Terahertz Sensing Based on Metasurfaces

Metasurfaces for biomedical applications: imaging and sensing from a nanophotonics perspective

Large Near-Field Enhancement in Terahertz Antennas by Using Hyperbolic Metamaterials with Hole Arrays

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