This work aims at studying digitalization trends affecting the economic security of the region. The object of the study is a region considered from the perspective of economic security. The subject is digitalization trends that have a multidirectional impact on the economic security of the region. The main digitalization trends affecting the economic security of the region are identified: the development of the digital economy, including digital business models; increasing the importance of intellectual capital and innovation potential; distribution of network forms of interaction among entities; formation of information threats to economic security; development of digital tools for managing the economic security of the region. During the study, the following effects for the economic security of the region were discovered: the emergence of new economic structures and development trends; the formation of threats caused by the development of digital technologies; the emergence of new opportunities and benefits from digitalization; the presence of threats that impede the development of digitalization at the regional level.