The “Three in One” Bone Repair Strategy for Osteoporotic Fractures

Chen, Xiao; Yan, Hu; Zhang, Geng; Su, Jiacan

doi:10.3389/fendo.2022.910602

Cited by 31 publications

(21 citation statements)

References 91 publications

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“…Bone defects caused by trauma, infection, malignancy, and osteoporotic fracture are prevalent with the lengthened lifespan and global aging trends [ 1 , 2 ]. Blood supply, age, and fundamental diseases, such as osteoporosis and diabetes, are variables that impact bone regeneration efficacy [ 3 , 4 ]. Among all clinically available grafts, autografts are the gold standard for treating bone defects.…”

Section: Introductionmentioning

confidence: 99%

Smart Hydrogels for Bone Reconstruction via Modulating the Microenvironment

et al. 2023

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Rapid and effective repair of injured or diseased bone defects remains a major challenge due to shortages of implants. Smart hydrogels that respond to internal and external stimuli to achieve therapeutic actions in a spatially and temporally controlled manner have recently attracted much attention for bone therapy and regeneration. These hydrogels can be modified by introducing responsive moieties or embedding nanoparticles to increase their capacity for bone repair. Under specific stimuli, smart hydrogels can achieve variable, programmable, and controllable changes on demand to modulate the microenvironment for promoting bone healing. In this review, we highlight the advantages of smart hydrogels and summarize their materials, gelation methods, and properties. Then, we overview the recent advances in developing hydrogels that respond to biochemical signals, electromagnetic energy, and physical stimuli, including single, dual, and multiple types of stimuli, to enable physiological and pathological bone repair by modulating the microenvironment. Then, we discuss the current challenges and future perspectives regarding the clinical translation of smart hydrogels.

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Section: Introductionmentioning

confidence: 99%

Smart Hydrogels for Bone Reconstruction via Modulating the Microenvironment

et al. 2023

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“…Therefore, introducing nutrients or stem cells from adjacent tissues is an effective strategy to accelerate cartilage repair 27 . Subchondral bone is adjacent to and underneath the cartilage and is rich in vascular tissue and a variety of stem cells 28 - 30 . Therefore, constructing osteochondral defects (so that nutrients and a variety of stem cells in the subchondral bone can arrive at the cartilage region) to achieve integrated osteochondral repair is expected to accelerate cartilage repair 31 , 32 .…”

Section: Introductionmentioning

confidence: 99%

Silk fibroin-based biomaterials for cartilage/osteochondral repair

Zhou¹,

Cui²,

Wu³

et al. 2022

Theranostics

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Osteoarthritis (OA) is a common joint disease with a high disability rate. In addition, OA not only causes great physiological and psychological harm to patients, but also puts great pressure on the social healthcare system. Pathologically, the disintegration of cartilage and the lesions of subchondral bone are related to OA. Currently, tissue engineering, which is expected to overcome the defects of existing treatment methods, had a lot of research in the field of cartilage/osteochondral repair. Silk fibroin (SF), as a natural macromolecular material with good biocompatibility, unique mechanical properties, excellent processability and degradability, holds great potential in the field of tissue engineering. Nowadays, SF had been prepared into various materials to adapt to the demands of cartilage/osteochondral repair. SF-based biomaterials can also be functionally modified to enhance repair performance further. In this review, the preparation methods, types, structures, mechanical properties, and functional modifications of SF-based biomaterials used for cartilage/osteochondral repair are summarized and discussed. We hope that this review will provide a reference for the design and development of SF-based biomaterials in cartilage/osteochondral repair field.

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“…Bone defects and fractures, caused by trauma and disease, endanger human health and affect the quality of life. [ 1 ] Approximately 5–10% of these bone failures develop into nonunions. [ 2 ] Currently, autologous and allogeneic bone grafts remain the “gold standard” for the clinical treatment of these bone‐related issues.…”

Section: Introductionmentioning

confidence: 99%

“…Bone defects and fractures, caused by trauma and disease, endanger human health and affect the quality of life. [1] Approximately 5-10% of these bone failures develop into nonunions. [2]…”

Section: Introductionmentioning

confidence: 99%

Bone Repair Biomaterials: A Perspective from Immunomodulation

Wang

Zhang

Yan

et al. 2022

Adv Funct Materials

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With an increasingly aging society, bone defects and fractures have become significant threats to human health and quality of life. Currently, autologous and allogeneic bone grafts remain the "gold standard" for the clinical treatment of bone repair. However, bone transplantation is still clinically insufficient, owing to its substantial limitations, such as graft rejection, donor functional defects, and risk of infection. Therefore, a variety of biomaterials have been developed to facilitate bone repair. With the advancement of bone tissue engineering, the focus of research has transitioned from bioinert to bioactive biomaterials. However, many biomaterials have not achieved satisfactory therapeutic effects. In recent years, advancements in osteoimmunology have revealed that the immune system, of which macrophages are critical components, plays an essential regulatory role in bone regeneration. In this review, the role of macrophages in bone healing is explored and recent developments in biomaterials that promote bone regeneration by modulating macrophage polarization and improving the osteoimmune microenvironment are reviewed. This review provides a reference for the development and clinical application of bone repair biomaterials from the immunomodulation perspective.

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The “Three in One” Bone Repair Strategy for Osteoporotic Fractures

Cited by 31 publications

References 91 publications

Smart Hydrogels for Bone Reconstruction via Modulating the Microenvironment

Smart Hydrogels for Bone Reconstruction via Modulating the Microenvironment

Silk fibroin-based biomaterials for cartilage/osteochondral repair

Bone Repair Biomaterials: A Perspective from Immunomodulation

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