The thyroid lobes: The different twins

Albi, Elisabetta; Curcio, Francesco; Spelat, Renza; Lazzarini, Remo; Loreti, Elisabetta; Ferri, Ivana; Ambesi-Impiombato, Francesco Saverio

doi:10.1016/j.abb.2011.12.001

Cited by 10 publications

(14 citation statements)

References 25 publications

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“…Intriguingly, STAT3 is more expressed in the right lobe than in the left lobe of thyroid, but the significance of this differential expression is currently unclear [82]. In normal thyroid glandular epithelium, Tyr705-phosphorylated STAT3 is distributed both in the cytoplasm and in the nucleus [26].…”

Section: Stat3 In Thyroidmentioning

confidence: 99%

The Role of STAT3 in Thyroid Cancer

Sosonkina

Starenki

Park

2014

Cancers

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Thyroid cancer is the most common endocrine malignancy and its global incidence rates are rapidly increasing. Although the mortality of thyroid cancer is relatively low, its rate of recurrence or persistence is relatively high, contributing to incurability and morbidity of the disease. Thyroid cancer is mainly treated by surgery and radioiodine remnant ablation, which is effective only for non-metastasized primary tumors. Therefore, better understanding of the molecular targets available in this tumor is necessary. Similarly to many other tumor types, oncogenic molecular alterations in thyroid epithelium include aberrant signal transduction of the mitogen-activated protein kinase, phosphatidylinositol 3-kinase/AKT (also known as protein kinase B), NF-кB, and WNT/β-catenin pathways. However, the role of the Janus kinase (JAK)/signal transducer and activator of transcription (STAT3) pathway, a well-known mediator of tumorigenesis in different tumor types, is relatively less understood in thyroid cancer. Intriguingly, recent studies have demonstrated that, in thyroid cancer, the JAK/STAT3 pathway may function in the context of tumor suppression rather than promoting tumorigenesis. In this review, we provide an update of STAT3 function in thyroid cancer and discuss some of the evidences that support this hypothesis.

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Section: Stat3 In Thyroidmentioning

confidence: 99%

The Role of STAT3 in Thyroid Cancer

Sosonkina

Starenki

Park

2014

Cancers

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“…We have previously demonstrated that while in the thyroid gland of WT control mice the follicles had variable size and spatial orientation, spaceflight animals presented a more homogenous thyroid tissue structure, with ordered follicles and reduction of interfollicular space [14]. Since most species C cells are mainly concentrated in the middle third of each thyroid lobe, the so-called C-cell region [15], we have focused the attention on this specific area.…”

Section: Resultsmentioning

confidence: 99%

“…For immunohistochemical analysis Bond Dewax solution was used for removal of paraffin from tissue sections before rehydration and immunostaining on the Bond automated system (Leica Biosystems Newcastle Ltd, UK) as previously reported [14]. Immunostaining for calcitonin detection was performed according to Bancroft and Stevens [15] by using NCL-L-calcitonin and Bond Polymer Refine Detection - Leica Biosystems ((Newcastle Ltd, UK).…”

Section: Methodsmentioning

confidence: 99%

Loss of Parafollicular Cells during Gravitational Changes (Microgravity, Hypergravity) and the Secret Effect of Pleiotrophin

Albi¹,

Curcio

Spelat

et al. 2012

PLoS ONE

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It is generally known that bone loss is one of the most important complications for astronauts who are exposed to long-term microgravity in space. Changes in blood flow, systemic hormones, and locally produced factors were indicated as important elements contributing to the response of osteoblastic cells to loading, but research in this field still has many questions. Here, the possible biological involvement of thyroid C cells is being investigated. The paper is a comparison between a case of a wild type single mouse and a over-expressing pleiotrophin single mouse exposed to hypogravity conditions during the first animal experiment of long stay in International Space Station (91 days) and three similar mice exposed to hypergravity (2Gs) conditions. We provide evidence that both microgravity and hypergravity induce similar loss of C cells with reduction of calcitonin production. Pleiotrophin over-expression result in some protection against negative effects of gravity change. Potential implication of the gravity mechanic forces in the regulation of bone homeostasis via thyroid equilibrium is discussed.

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“…For immunohistochemical analysis Bond Dewax solution was used for removal of paraffin from tissue sections before rehydration and immunostaining on the Bond automated system (Leica Biosystems Newcastle Ltd, UK) as previously reported [ 17 ]. Immunostaining detection was performed according to Bancroft and Stevens [ 18 ] by using HBME-1 and Ki-67 (MIB-1 clone) from Dako (Milano, Italy) and CK19 and Gal-3 antibodies and Bond Polymer Refine Detection from Leica Biosystems (Newcastle Ltd, UK).…”

Section: Methodsmentioning

confidence: 99%

How Microgravity Changes Galectin-3 in Thyroid Follicles

Albi

Curcio

Lazzarini

et al. 2014

BioMed Research International

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After long-term exposure to real microgravity thyroid gland in vivo undergoes specific changes, follicles are made up of larger thyrocytes that produce more cAMP and express more thyrotropin-receptor, caveolin-1, and sphingomyelinase and sphingomyelin-synthase; parafollicular spaces lose C cells with consequent reduction of calcitonin production. Here we studied four immunohistochemical tumor markers (HBME-1, MIB-1, CK19, and Galectin-3) in thyroid of mice housed in the Mouse Drawer System and maintained for 90 days in the International Space Station. Results showed that MIB-1 proliferative index and CK19 are negative whereas HBME-1 and Galectin-3 are overexpressed. The positivity of Galectin-3 deserves attention not only for its expression but also and especially for its localization. Our results highlighted that, in microgravity conditions, Galectin-3 leaves thyrocytes and diffuses in colloid. It is possible that the gravity force contributes to the maintenance of the distribution of the molecules in both basal membrane side and apical membrane side and that the microgravity facilitates slippage of Galectin-3 in colloid probably due to membrane remodelling-microgravity induced.

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The thyroid lobes: The different twins

Cited by 10 publications

References 25 publications

The Role of STAT3 in Thyroid Cancer

The Role of STAT3 in Thyroid Cancer

Loss of Parafollicular Cells during Gravitational Changes (Microgravity, Hypergravity) and the Secret Effect of Pleiotrophin

How Microgravity Changes Galectin-3 in Thyroid Follicles

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