The TOP-IMPLART project

Ronsivalle, C.; Carpanese, M.; Mariño, Cecilia Nuria Gil; Messina, Giovanni; Picardi, L.; Sandri, Sandro; Basile, Elisa; Caccia, Barbara; Castelluccio, Donato Maurizio; Cisbani, E.; Frullani, S.; Ghio, F.; Macellari, Velio; Benassi, Marcello; D’Andrea, M.; Strigari, Lidia

doi:10.1140/epjp/i2011-11068-x

Cited by 58 publications

(30 citation statements)

References 5 publications

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“…Linear accelerators (linacs) historically pre-date all the accelerator types mentioned so far [58], Wideroe having first proposed the concept in the 1920s to overcome the limitations of static voltages [83]. [84,85,86,87,88], and the TERA LIBO side-coupled structure has been adopted as the technology for the Advanced Oncotherapy (AVO) linacbased solution presently under construction at CERN. Similar to other applications of linacs one issue is about beam injection into such high-frequency structures.…”

Section: Linacsmentioning

confidence: 99%

Current and future accelerator technologies for charged particle therapy

Owen

Lomax

Jolly

2016

Nuclear Instruments and Methods in Physics Research Section A:

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The past few years have seen significant developments both of the technologies available for proton and other charged particle therapies, and of the number and spread of therapy centres. In this review we give an overview of these technology developments, and outline the principal challenges and opportunities we see as important in the next decade. Notable amongst these is the ever-increasing use of superconductivity both in particle sources and for treatment delivery, which is likely to greatly increase the accessibility of charged particle therapy treatments to hospital centres worldwide.

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Section: Linacsmentioning

confidence: 99%

Current and future accelerator technologies for charged particle therapy

Owen

Lomax

Jolly

2016

Nuclear Instruments and Methods in Physics Research Section A:

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“…However, in recent years several developments have been made to achieve high enough gradients to enable use in a hospital setting, for example by the TERA and TOP-IMPART collaborations (greater than 10 MV m −1 ) [94][95][96][97][98]. In both these cases 3 GHz normal-conducting accelerating structures have been proposed to achieve gradients above 20 MV m −1 ; in the case of the TERA LIBO proton linac a side-coupled linac is used [99], and has been chosen by at least one commercial company (Advanced Oncotherapy) as a technology to be integrated for patient treatment [100].…”

Section: Linacsmentioning

confidence: 99%

Hadron accelerators for radiotherapy

Owen

Mackay

Peach

et al. 2014

Contemporary Physics

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Over the last twenty years the treatment of cancer with protons and light nuclei such as carbon ions has moved from being the preserve of research laboratories into widespread clinical use. A number of choices now exist for the creation and delivery of these particles, key amongst these being the adoption of pencil beam scanning using a rotating gantry; attention is now being given to what technologies will enable cheaper and more effective treatment in the future. In this article the physics and engineering used in these hadron therapy facilities is presented, and the research areas likely to lead to substantive improvements. The wider use of superconducting magnets is an emerging trend, whilst further ahead novel high-gradient acceleration techniques may enable much smaller treatment systems. Imaging techniques to improve the accuracy of treatment plans must also be developed hand-in-hand with future sources of particles, a notable example of which is proton computed tomography.

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“…In 2012, the Innovation Department of Regione Lazio funded a project named Terapia Oncologica con Protoni-Intensity Modulated Proton Linear Accelerator for Radio Therapy (TOP-IMPLART) [8], aiming to realize and validate a prototype of a linear accelerator, built with SCDTL technology, dedicated to proton therapy. The accelerator is under development at the ENEA research center in Frascati, in collaboration with the Italian Institute of Health, and the Oncological Hospital IFO.…”

Section: Introductionmentioning

confidence: 99%

“…For instance, the output charge rate can be flexibly varied by either changing the injector current, shortening the current pulse duration, or changing the optics parameters in the injection line. Output energy can be varied by switching off some of the modules and adjusting the rf power level in the last one [4,8]. Thus, intensity and energy could be changed ideally at each pulse (i.e., every 5-10 ms), resulting in a fast and effective modulation of the output beam.…”

Section: Introductionmentioning

confidence: 99%

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Beam commissioning of the 35 MeV section in an intensity modulated proton linear accelerator for proton therapy

Picardi

Ampollini

Bazzano

et al. 2020

Phys. Rev. Accel. Beams

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This paper presents the experimental results on the Terapia Oncologica con Protoni-Intensity Modulated Proton Linear Accelerator (TOP-IMPLART) beam that is currently accelerated up to 35 MeV, with a final target of 150 MeV. The TOP-IMPLART project, funded by the Innovation Department of Regione Lazio (Italy), is led by Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA) in collaboration with the Italian Institute of Health and the Oncological Hospital Regina Elena-IFO. The accelerator, under construction and test at ENEA-Frascati laboratories, employs a commercial 425 MHz, 7 MeV injector followed by a sequence of 3 GHz accelerating modules consisting of side coupled drift tube linac (SCDTL) structures up to 71 MeV and coupled cavity linac structures for higher energies. The section from 7 to 35 MeV, consisting on four SCDTL modules, is powered by a single 10 MW klystron and has been successfully commissioned. This result demonstrates the feasibility of a "fully linear" proton therapy accelerator operating at a high frequency and paves the way to a new class of machines in the field of cancer treatment.

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The TOP-IMPLART project

Cited by 58 publications

References 5 publications

Current and future accelerator technologies for charged particle therapy

Current and future accelerator technologies for charged particle therapy

Hadron accelerators for radiotherapy

Beam commissioning of the 35 MeV section in an intensity modulated proton linear accelerator for proton therapy

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