The Toxicity Effect of Certain Photosensitizing Compounds on Some Biological Aspects of Field Strain of Agrotis ipsilon (Hufnagel) Larvae

Abd-El-Aziz, Hanan S; habit, Amal Th.

doi:10.21608/eajbsf.2021.161394

Cited by 3 publications

(2 citation statements)

References 17 publications

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“…This specific wavelength range ensures efficient activation of SF during PDT. Additionally, SF exhibits low toxicity in the absence of light, enhancing its safety profile as a therapeutic agent [17,18]. Furthermore, SF has found applications beyond PDT, particularly in the field of photo-oxidation of organic compounds [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

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Advancing Photodynamic Therapy Efficiency on MCF-7 Breast Cancer Cells through Silica Nanoparticles-Safranin Encapsulation: In-Vitro Evaluation

et al. 2023

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Efficient drug delivery to target tissue is a major challenge in many cancer treatment modalities. Silica nanoparticles (SiNPs) have been identified as an ideal drug carrier due to their unique properties. In Photodynamic therapy (PDT), one of the key challenges in utilizing photosensitizers (PS) lies in effectively delivering the PS to the targeted tissue. Using Silica nanoparticles encapsulation will effectively prevent the leakage of entrapped PS from the particles, protects against reduction by the retinal endothelial system, and reduces PS toxicity. In this study, Silica nanoparticles (SiNPs) were used as carriers for Safranin (SF) as a photosensitizer agent to treat MCF-7 breast cancer cells in vitro. The SiNPs nanoparticles were synthesized, and their size and shape were measured using Transmission Electron Microscopy (TEM). Cytotoxicity was evaluated for different concentrations of encapsulated and naked SF. The optimal concentrations and exposure times required to eliminate the MCF-7 under light (Intensity ~110 mW/cm2, red laser) were determined. The results indicated that encapsulated SF by SiNPs exhibited higher efficacy than naked SF with a +50% concentration efficacy and +78% exposure time efficacy. This confirmed the superior ability of encapsulated SF to eliminate MCF-7 cells compared to naked SF. The use of synthesized silica nanoparticles loaded with SF improved photodynamic therapy by increasing the bioavailability of SF in the target cells. Our results demonstrate that SiNP encapsulation significantly improves the efficacy of SF in eliminating MCF-7 cells compared to bare SF. This study underscores the potential of SiNPs as a drug delivery system for photodynamic therapy and could pave the way for developing more effective cancer treatments.

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Section: Introductionmentioning

confidence: 99%

“…References [15][16][17]. SF's versatility makes it a highly appealing option for diverse research domains, encompassing tissue structure, cellular studies, and investigations involving bacteria [22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Advancing Photodynamic Therapy Efficiency on MCF-7 Breast Cancer Cells through Silica Nanoparticles-Safranin Encapsulation: In-Vitro Evaluation

et al. 2023

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Acaricide resistance and novel photosensitizing approach as alternative acaricides against the camel tick, Hyalomma dromedarii

Mohammed

Baz

Ibrahim

et al. 2022

Photochem Photobiol Sci

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The control of the camel tick, Hyalomma dromedarii is very crucial. This study evaluated the novel toxicity of photosensitizers and Phoxim insecticide against H. dromedarii males using the adult immersion tests. Ticks were subjected to sunlight for 10 min post-treatment (PT). The optical characters of the applied materials were determined by UV–Vis spectroscopy (250–900 nm wavelengths). The intensity of spectra decreased as dye concentration decreased. The optical bandgap energies of the dyes at different concentrations were not changed as the concentration changed and decreased as the absorption peak of individual dyes red-shifted. The mortalities 72 h PT reached 42.2%, 44.4%, 51.1%, 71.1%, 46.7%, 48.9%, 44.4%, and 55.6% for chlorophyllin, echinochrome, field stain, methylene blue, phthalocyanine, rhodamine 6G, riboflavin, and safranin, respectively. Methylene blue recorded the highest median lethal concentration (LC50 = 127 ppm) followed by safranin, field stain, rhodamine 6G, phthalocyanine, echinochrome riboflavin, and chlorophyllin (LC50 = 209, 251, 271, 303, 324, 332, and 362 ppm, respectively, 72 h PT). Their median lethal time, LT50, values PT with 240 ppm were 45, 87, 96, 72, 129, 115, 131, and 137 h, respectively. The relative toxicities of the LC50 values 72 h PT showed that chlorophyllin, echinochrome, field stain, methylene blue, phthalocyanine, rhodamine 6G, riboflavin, and safranin were 3.2, 3.6, 4.6, 9.1, 3.8, 4.3, 3.5, and 5.6 times, respectively, more effective than Phoxim. Methylene blue, safranin, and field stain showed a broad absorbance area indicating a large photoactivity and better phototoxicity and could be used as alternative agents to synthetic acaricides. Graphical Abstract

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Casting light on the potency of photosensitizing compounds to combat the spiny bollworm, Earias insulana (Biosd.)

El-Shennawy,

Kandil,

El-shourbagy

et al. 2024

Archives of Phytopathology and Plant Protection

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The Toxicity Effect of Certain Photosensitizing Compounds on Some Biological Aspects of Field Strain of Agrotis ipsilon (Hufnagel) Larvae

Cited by 3 publications

References 17 publications

Advancing Photodynamic Therapy Efficiency on MCF-7 Breast Cancer Cells through Silica Nanoparticles-Safranin Encapsulation: In-Vitro Evaluation

Advancing Photodynamic Therapy Efficiency on MCF-7 Breast Cancer Cells through Silica Nanoparticles-Safranin Encapsulation: In-Vitro Evaluation

Acaricide resistance and novel photosensitizing approach as alternative acaricides against the camel tick, Hyalomma dromedarii

Casting light on the potency of photosensitizing compounds to combat the spiny bollworm, Earias insulana (Biosd.)

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