The Tracking Ratio Station

Hägglund, Tore

doi:10.1016/j.conengprac.2017.09.016

Cited by 4 publications

(1 citation statement)

References 8 publications

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“…From the time-dependent properties, the most important one when closed-loop control is envisaged is the fluid (mixture) density variability. This is of particular importance in mixtures based on feedforward and ratio control structures [25,26].…”

Section: Measuring Impedance In Non-newtonian Materialsmentioning

confidence: 99%

Impedance Spectroscopy Sensing Material Properties for Self-Tuning Ratio Control in Pharmaceutical Industry

et al. 2022

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Following the paradigm shift in the pharmaceutical industry from batch to continuous production, additional instrumentation and revision of control strategies to optimize material flow throughout the downstream processes are required. Tableting manufacturing is one of the most productive in terms of turnover and investment into new sensor technologies is an important decision-making step. This paper proposes a continuous solution to detect changes in material properties, and a control algorithm to aid in minimizing risk at the end-product line. Some of the sub-processes involved in tableting manufacturing perform changes in powder and liquid mixtures, granulation, density, therefore changing flow conditions of the raw material. Using impedance spectroscopy in a continuous sensing and monitoring context, it is possible to perform online identification of generalized (fractional) order parametric models where the coefficients are correlated to changes in material properties. The model parameters are then included in a self-tuning control gain used in ratio control as part of the local process control loop. The solution proposed here is easy to implement and poses a significant added value to the current state of art in pharmaceutical manufacturing technologies.

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Section: Measuring Impedance In Non-newtonian Materialsmentioning

confidence: 99%