The TRAF2 and TRAF6 expression in myomas and myometrium of women in reproduction and perimenopausal age.

Plewka, Andrzej; Madej, Paweł; Plewka, Danuta; Nowaczyk, Grażyna; Morek, Michał; Bogunia, Edyta; Ciupińska-Kajor, Monika; Sieroń–Stołtny, Karolina

doi:10.2478/v10042-010-0039-6

Cited by 7 publications

(3 citation statements)

References 36 publications

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“…These results are consistent with studies of Kurachi et al [34] who showed that the expression of TNF-a in leiomyoma cells was higher than that in the normal myometrial cells and could be down-regulated by progesterone. Activity of IL-1b and TNF-a is particularly important since, on the one hand, they may directly affect the level of inducible cyclooxygenase [16,35] and, on the other, they may indirectly, through TRAF proteins, stimulate activation of the NF-kB transcription factor [21]. We found that the expression profile of COX-2 was similar to the one of TNF-a.…”

Section: Discussionmentioning

confidence: 52%

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Immunohistochemical localization of selected pro-inflammatory factors in uterine myomas and myometrium in women of various ages

Plewka

Madej

Plewka

et al. 2013

Folia Histochem Cytobiol.

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Uterine myomas represent one of the most frequently manifested benign tumors in women. They originate from smooth muscle cells of myometrium or its blood vessels. Many studies suggest that inflammation and pro-inflammatory factors may play a role in the carcinogenesis with an involvement of the transcription factor NF-kB which activity can be controlled by various environmental factors, including many cytokines. The aim of the study was to investigate the expression of NF-B, interleukin-1b (IL-1b), tumor necrosis factor a (TNF-a), cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS) in myometrium and uterine myomas of women of various age. The expression of NF-kB, selected cytokines and enzymes was estimated in women of reproductive or perimenopausal age by semiquantitative immunohistochemistry. The expression of the examined proteins was higher in myomas than in control myometrium and was dependent on the size of myomas and the age of women. However, the expression of the cytoplasmic NF-kB observed in uterine myomas was independent on the size of myomas and no significant differences were observed in the number of stained nuclei between control and myoma groups. Thus, the expression of proinflammatory factors in myomas was not accompanied by the nuclear activation of NF-kB p65. The results of our study indicate that the examined factors may be involved in the pathogenesis of benign tumors and not only malignant diseases.

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Section: Discussionmentioning

confidence: 52%

“…IL-1b and TNF-a stimulate TRAF6 (tumor necrosis factor receptor associated factor 6) [21], the effect of which directly stimulates the expression of NF-kB [22]. IL-1b and TNF-a increase the level of iNOS mRNA by transcriptional activation [23].…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical localization of selected pro-inflammatory factors in uterine myomas and myometrium in women of various ages

Plewka

Madej

Plewka

et al. 2013

Folia Histochem Cytobiol.

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“…It is a cytoplasmic protein that plays a role in apoptosis and cell survival [11]. We do not know the exact mechanism of cancer cachexia, but atrophy in muscles may have a prognostic role in this process.…”

Section: Discussionmentioning

confidence: 99%

The prognostic role of inflammation and hormones in patients with metastatic cancer with cachexia

et al. 2015

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We wanted to investigate the possible etiologic factors of cachexia. Forty-six patients diagnosed with cancer cachexia and 34 healthy controls were included in the study. Serum total testosterone, free testosterone, interleukin 1 (IL) alpha and beta, IL6, tumor necrosis factor (TNF) alpha, orexin, galanin, neuropeptide Y, tumor necrosis factor-like weak inducer of apoptosis and tumor necrosis factor receptor-associated factor 6, and C-reactive protein (CRP) levels were investigated. There were 36 male and 10 female patients in the cachexia group, and 24 male and 10 female patients in the control group. Median overall survival (OS) of the cachexia group after the diagnosis of cachexia was 8 (1-25) months. There were statistically significant relationships between OS and BMI, serum CRP, TRAF-6, albumin, and LDH levels in the cachexia group. In addition to cachexia, serum CRP, testosterone, and TNF alpha levels were statistically significantly correlated with OS in refractory cachexia. TRAF-6 levels was significantly correlated with type of cancer (P = 0.02). Although cachexia presents with a multifactorial ethio-pathogenesis, few of them affect the OS. Our novel results were that serum CRP, albumin, LDH, and TRAF-6 levels have a higher association with OS in patients with cancer cachexia compared to the many other parameters. An ongoing cachexia also called refractory cachexia is a recent definition. This end-stage term of cancer duration may be predicted by decreasing serum testosterone and increasing serum TNF alpha levels, as well as serum CRP levels.

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Supplementation with d-chiro-inositol in women

Laganà

Aragona

Prapas

2023

A Clinical Guide to Inositols

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The TRAF2 and TRAF6 expression in myomas and myometrium of women in reproduction and perimenopausal age.

Cited by 7 publications

References 36 publications

Immunohistochemical localization of selected pro-inflammatory factors in uterine myomas and myometrium in women of various ages

Immunohistochemical localization of selected pro-inflammatory factors in uterine myomas and myometrium in women of various ages

The prognostic role of inflammation and hormones in patients with metastatic cancer with cachexia

Supplementation with d-chiro-inositol in women

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