The transcriptional factor Apt regulates neuroblast differentiation through activating CycE expression

Shen, Yang; Wang, Luwei; Hirose, Susumu; Zhou, Zizhang; Liu, Qingxin

doi:10.1016/j.bbrc.2018.04.012

Cited by 5 publications

(3 citation statements)

References 26 publications

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“…In GB 6-4A, the Hox gene downregulation of CycE allows both daughter cells of the GB to become glial precursors. Another component that regulates glial-neuronal differences in NB 6-4 is the Apt TF (Shen et al 2018). apt is expressed in NB 6-4T and activates CycE expression leading to neuronal fates, while gcm in NG 6-4A suppresses apt and CycE expression, thus supporting glial fates.…”

Section: Specification Of Glial Cell Fate In Individual Glial Precursorsmentioning

confidence: 99%

Drosophila Embryonic CNS Development: Neurogenesis, Gliogenesis, Cell Fate, and Differentiation

Crews

2019

Genetics

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The Drosophila embryonic central nervous system (CNS) is a complex organ consisting of ∼15,000 neurons and glia that is generated in ∼1 day of development. For the past 40 years, Drosophila developmental neuroscientists have described each step of CNS development in precise molecular genetic detail. This has led to an understanding of how an intricate nervous system emerges from a single cell. These studies have also provided important, new concepts in developmental biology, and provided an essential model for understanding similar processes in other organisms. In this article, the key genes that guide Drosophila CNS development and how they function is reviewed. Features of CNS development covered in this review are neurogenesis, gliogenesis, cell fate specification, and differentiation.

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Section: Specification Of Glial Cell Fate In Individual Glial Precursorsmentioning

confidence: 99%

Drosophila Embryonic CNS Development: Neurogenesis, Gliogenesis, Cell Fate, and Differentiation

Crews

2019

Genetics

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“…Indeed, the same group determined that these two functions of CycE are mediated through distinct protein domains, and that CycE both promotes the cortical localization of Prospero protein, and interferes with Pros-mediated gene regulation [68]. More recently, the upstream factors glial cell missing (gcm) and apontic (Apt) were found to be differentially expressed between thoracic and abdominal NB6-4, resulting in restriction of CycE expression to the thoracic NB6-4 [69]. These findings provide the most direct evidence for how Hox-mediated differences in segmental identity influence neuroblast proliferation behavior.…”

Section: Control Of Stem Cell Proliferation: Self-renewal and Amplmentioning

confidence: 99%

Drosophila as a Model for Developmental Biology: Stem Cell-Fate Decisions in the Developing Nervous System

Harding

White

2018

JDB

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Stem cells face a diversity of choices throughout their lives. At specific times, they may decide to initiate cell division, terminal differentiation, or apoptosis, or they may enter a quiescent non-proliferative state. Neural stem cells in the Drosophila central nervous system do all of these, at stereotypical times and anatomical positions during development. Distinct populations of neural stem cells offer a unique system to investigate the regulation of a particular stem cell behavior, while comparisons between populations can lead us to a broader understanding of stem cell identity. Drosophila is a well-described and genetically tractable model for studying fundamental stem cell behavior and the mechanisms that underlie cell-fate decisions. This review will focus on recent advances in our understanding of the factors that contribute to distinct stem cell-fate decisions within the context of the Drosophila nervous system.

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“…One candidate for such factor is Apt. Drosophila Apt (also termed Trachea defective, Tdf) is a DNA-binding transcription factor that is involved in the development of multiple organs and tissues, such as tracheae, head, heart, ovary, stem cell, nervous system, and imaginal discs ( Eulenberg and Schuh, 1997 ; Gellon et al., 1997 ; Lie and Macdonald, 1999 ; Liu et al., 2003 , 2014 ; Monahan and Starz-Gaiano, 2016 ; Shen et al., 2018 ; Starz-Gaiano et al., 2008 ; Su et al., 1999 ; Wang et al., 2017 ). We have found that Apt directly regulates the expression of cycE during the development of imaginal discs ( Liu et al., 2014 ; Wang et al., 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Evolutionarily Conserved Roles for Apontic in Induction and Subsequent Decline of Cyclin E Expression

Wang

Liu

et al. 2020

iScience

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Summary Cyclin E is a key factor for S phase entry, and deregulation of Cyclin E results in developmental defects and tumors. Therefore, proper cycling of Cyclin E is crucial for normal growth. Here we found that transcription factors Apontic (Apt) and E2f1 cooperate to induce cyclin E in Drosophila . Functional binding motifs of Apt and E2f1 are clustered in the first intron of Drosophila cyclin E and directly contribute to the cyclin E transcription. Knockout of apt and e2f1 together abolished Cyclin E expression. Furthermore, Apt up-regulates Retinoblastoma family protein 1 (Rbf1) for proper chromatin compaction, which is known to repress cyclin E . Notably, Apt-dependent up-regulation of Cyclin E and Rbf1 is evolutionarily conserved in mammalian cells. Our findings reveal a unique mechanism underlying the induction and subsequent decline of Cyclin E expression.

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The transcriptional factor Apt regulates neuroblast differentiation through activating CycE expression

Cited by 5 publications

References 26 publications

Drosophila Embryonic CNS Development: Neurogenesis, Gliogenesis, Cell Fate, and Differentiation

Drosophila Embryonic CNS Development: Neurogenesis, Gliogenesis, Cell Fate, and Differentiation

Drosophila as a Model for Developmental Biology: Stem Cell-Fate Decisions in the Developing Nervous System

Evolutionarily Conserved Roles for Apontic in Induction and Subsequent Decline of Cyclin E Expression

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