The transgenic chicken derived anti-CD20 monoclonal antibodies exhibits greater anti-cancer therapeutic potential with enhanced Fc effector functions

Three-dimensional culture of chicken primordial germ cells (cPGCs) in defined media containing the functional polymer FP003

“…Glycosylation of avian-derived proteins for therapeutic purposes was recently discussed [ 14 , 15 , 32 ]. For instance, the humanized properties in the terminal residue of N-glycans in chicken protein indicates a low allergic risk for clinic application [ 16 ].…”

“…For instance, the humanized properties in the terminal residue of N-glycans in chicken protein indicates a low allergic risk for clinic application [ 16 ]. Moreover, reduced fucosylation in avian derived antibodies shows an enhanced therapeutic function [ 14 , 15 , 32 ]. Eggs are considered an ideal platform for recombinant protein production, and the ovalbumin promoter shows a robust and specific expression ability in oviducts.…”

Precise Genome Editing in Poultry and Its Application to Industries

“…Each egg white contains an average of 3.5 g of protein, of which ovalbumin constitutes half [ 85 , 87 ]. Due to the predominance of ovalbumin, researchers have attempted to express therapeutic proteins under the control of a synthetic ovalbumin promoter [ 8 , 9 , 10 , 11 , 12 ]. Recently, knock-in of a therapeutic protein at the ovalbumin locus, enabling expression of the protein under the control of the endogenous ovalbumin promoter, was successfully performed [ 14 ].…”

“…Moreover, chicken egg white proteins have a characteristic N -glycosylation pattern that can improve the efficacy of protein drugs. Based on these properties, several studies have reported production and purification of protein drugs from egg white and demonstrated their efficacy [ 8 , 9 , 10 , 11 , 12 ]. Recently, an enzyme used to treat Wolman disease was purified from egg white and commercialized [ 13 ].…”

Analysis of Transcriptional Activity and Estrogen Responsiveness of Regulatory Elements in Chicken Ovalbumin Promoter

“…이 사용되고 있다 (Harvey et al, 2002;Rapp et al, 2003;Kamihara et al, 2005;Zhu et al, 2005;Park et al, 2015;Kim et al, 2018;Oishi et al, 2018). 특히, 닭은 포유류와 다 르게 짧은 세대간격, 적은 사양 비용, 그리고 재조합 산물의 안전성 등에 대한 이점들로 인하여 생물반응기 동물로 활용 했을 때 다른 동물 종보다 유리한 것으로 알려져 있다 (Lillico et al, 2006;Robert, 2006).…”