The Translationally Controlled Tumor Protein Is a Novel Calcium Binding Protein of the Human Placenta and Regulates Calcium Handling in Trophoblast Cells1

Arcuri, Felice; Papa, Stefania; Meini, Antonella; Carducci, A; Romagnoli, Roberta; Bianchi, Laura; Riparbelli, Maria Giovanna; Sanchez, Jean‐Charles; Palmi, Mitri; Tosi, Piero; Cintorino, Marcella

doi:10.1095/biolreprod.105.042077

Cited by 33 publications

(19 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The notion of TCTP acting as a Ca 2+ -scavenger, or more generally as a 'buffer-like' molecule for Ca 2+ , is consistent with its high abundance and with the fact that its binding site is rather weak (Lucas et al 2014). The importance of such a Ca 2+ -buffer-like function for TCTP was described for trophoblast cells of the placenta, where it is involved in Ca 2+ -handling and in its provision for the foetal blood circulation (Arcuri et al 2005). Similarly, in human prostate epithelial cells, TCTP is the Ca 2+ -binding protein with the highest expression levels (Arcuri et al 2004).…”

Section: Involvement In Cellular Stress Responsesmentioning

confidence: 72%

“…Later, it was shown that TCTP levels are regulated in response to perturbations of intracellular Ca 2+ -homeostasis (Xu et al 1999). Although TCTP does not have a canonical Ca 2+ -binding site , its Ca 2+ -binding activity has been confirmed by several laboratories using a range of methods (Feng et al 2007a;Graidist et al 2007;Kim et al 2000;Lucas et al 2014;Arcuri et al 2004Arcuri et al , 2005Sanchez et al 1997). However, the different approaches used to map the Ca 2+ -binding site at the TCTP protein yielded different results (Feng et al 2007a;Graidist et al 2007;Kim et al 2000).…”

Section: Involvement In Cellular Stress Responsesmentioning

confidence: 99%

“…The first reports on the role for TCTP in the mammalian reproductive system appeared about 15 years ago. Specifically, the developmental expression of TCTP in the rat and human testes were studied by the group of Sanchez and Hochstrasser in Geneva (Guillaume et al 2001), and the importance of TCTP as a Ca 2+ -binding protein in the prostate (Arcuri et al 2004) and the placenta (Arcuri et al 2005) were demonstrated by Arcuri et al A more recent study showed that TCTP is essential for the implantation of embryos in the uterus of mice ). An important role for TCTP in egg production in nematodes, such as C. elegans, was demonstrated by TCTP knock-down, which severely reduced the number of eggs produced by these worms (Meyvis et al 2009), consistent with the role of TCTP for meiotic maturation demonstrated in mouse oocytes (Jeon et al 2016).…”

Section: Roles For Tctp In Early Developmentmentioning

confidence: 99%

See 2 more Smart Citations

The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation

Bommer

2017

Results and Problems in Cell Differentiation

View full text Add to dashboard Cite

The Translational Controlled Tumour Protein TCTP (gene symbol TPT1, also called P21, P23, Q23, fortilin or histamine-releasing factor, HRF) is a highly conserved protein present in essentially all eukaryotic organisms and involved in many fundamental cell biological and disease processes. It was first discovered about 35 years ago, and it took an extended period of time for its multiple functions to be revealed, and even today we do not yet fully understand all the details. Having witnessed most of this history, in this chapter, I give a brief overview and review the current knowledge on the structure, biological functions, disease involvements and cellular regulation of this protein. TCTP is able to interact with a large number of other proteins and is therefore involved in many core cell biological processes, predominantly in the response to cellular stresses, such as oxidative stress, heat shock, genotoxic stress, imbalance of ion metabolism as well as other conditions. Mechanistically, TCTP acts as an anti-apoptotic protein, and it is involved in DNA-damage repair and in cellular autophagy. Thus, broadly speaking, TCTP can be considered a cytoprotective protein. In addition, TCTP facilitates cell division through stabilising the mitotic spindle and cell growth through modulating growth signalling pathways and through its interaction with the proteosynthetic machinery of the cell. Due to its activities, both as an anti-apoptotic protein and in promoting cell growth and division, TCTP is also essential in the early development of both animals and plants. Apart from its involvement in various biological processes at the cellular level, TCTP can also act as an extracellular protein and as such has been involved in modulating whole-body defence processes, namely in the mammalian immune system. Extracellular TCTP, typically in its dimerised form, is able to induce the release of cytokines and other signalling molecules from various types of immune cells. There are also several examples, where TCTP was shown to be involved in antiviral/antibacterial defence in lower animals. In plants, the protein appears to have a protective effect against phytotoxic stresses, such as flooding, draught, too high or low temperature, salt stress or exposure to heavy metals. The finding for the latter stress condition is corroborated by earlier reports that TCTP levels are considerably up-regulated upon exposure of earthworms to high levels of heavy metals. Given the involvement of TCTP in many biological processes aimed at maintaining cellular or whole-body homeostasis, it is not surprising that dysregulation of TCTP levels may promote a range of disease processes, foremost cancer. Indeed a large body of evidence now supports a role of TCTP in at least the most predominant types of human cancers. Typically, this can be ascribed to both the anti-apoptotic activity of the protein and to its function in promoting cell growth and division. However, TCTP also appears to be involved in the later stages of cancer progression, such ...

show abstract

Section: Involvement In Cellular Stress Responsesmentioning

confidence: 72%

Section: Involvement In Cellular Stress Responsesmentioning

confidence: 99%

Section: Roles For Tctp In Early Developmentmentioning

confidence: 99%

See 1 more Smart Citation

The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation

Bommer

2017

Results and Problems in Cell Differentiation

View full text Add to dashboard Cite

show abstract

“…The number of implanted embryos was reduced when TCTP levels were downregulated by injection of antisense oligos. Arcuri et al [38] described a role for TCTP in Ca ++ -handling and transport in the placenta. TCTP knock-down was associated with reduced cellular calcium-uptake and buffering capacity.…”

Section: • Tctp As a General Mitotic Regulatormentioning

confidence: 99%

Cellular Function and Regulation of the Translationally Controlled Tumour Protein TCTP

Bommer¹

2012

TOALLJ

View full text Add to dashboard Cite

Abstract:The 'translationally controlled tumour protein' TCTP was originally discovered 30 years ago by researchers interested in proteins regulated at the translational level. Cloning and sequencing confirmed the conservation of this protein among all eukaryotic kingdoms, but did not reveal any functional clue, and TCTP was listed in the databases as a 'family' of its own. The functional characterisation of this protein extended over more than a decade, leading to a plethora of individual functions and interactions that have been ascribed to this protein. A major addition to the functional characterisation of TCTP was the identification in 1995 of its histamine releasing factor (HRF) activity in allergic conditions, which for the first time described an extracellular activity for TCTP in human disease. This triggered a host of additional publications aimed at characterising this HRF activity, which are discussed in other articles of this issue. Another milestone in the elucidation of TCTP's function was the demonstration of its anti-apoptotic activity in 2001. Evidence is also accumulating for a role of TCTP in the cell cycle and in early development. This article provides an overview of the main cellular activities of TCTP. The second part will summarise our current knowledge on the mechanisms involved in regulating intracellular TCTP levels.

show abstract

“…It plays important roles in cellular and physiological processes, such as tumor reversion, cell division and proliferation, differentiation, cell cycle progression, microtubule organization, protection against various stress conditions and apoptosis (Amson et al 2013). TCTP is also a calcium binding protein and the knockout of TCTP affected the absorption of calcium in human trophoblast cells (Arcuri et al 2005). Otherwise, TCTP displays similar function in animals and plants.…”

Section: Introductionmentioning

confidence: 99%

A translationally controlled tumor protein gene Rpf41 is required for the nodulation of Robinia pseudoacacia

et al. 2015

View full text Add to dashboard Cite

Translationally controlled tumor protein (TCTP) is fundamental for the regulation of development and general growth in eukaryotes. Its multiple functions have been deduced from its involvement in several cell pathways, but its potential involvement in symbiotic nodulation of legumes cannot be suggested a priori. In the present work, we identified and characterized from the woody leguminous tree Robinia pseudoacacia a homolog of TCTP, Rpf41, which was up-regulated in the infected roots at 15 days post-inoculation but decreased in the matured nodules. Subcellular location assay showed that Rpf41 protein was located in the plasma membrane, cytoplasm, nucleus, and also maybe in cytoskeleton. Knockdown of Rpf41 via RNA interference (RNAi) resulted in the impaired development of both nodule and root hair. Compared with wild plants, the root and stem length, fresh weight and nodule number per plant was decreased dramatically in Rpf41 RNAi plants. The number of ITs or nodule primordia was also significantly reduced in the Rpf41 RNAi roots. The analyses of nodule ultrastructure showed that the infected cell development in Rpf41 RNAi nodules remained in zone II, which had fewer infected cells. Furthermore, the symbiosomes displayed noticeable shrinkage of bacteroid and peribacteroid space enlargement in the infected cells of Rpf41 RNAi nodules. In the deeper cell layers, a more remarkable aberration of the infected cell ultrastructure was observed, and electron-transparent lesions in the bacteroid cytoplasm were detected. These results identify TCTP as an important regulator of symbiotic nodulation in legume for the first time, and it may be involved in symbiotic cell differentiation and preventing premature aging of the young nodules in R. pseudoacacia.

show abstract

The Translationally Controlled Tumor Protein Is a Novel Calcium Binding Protein of the Human Placenta and Regulates Calcium Handling in Trophoblast Cells1

Cited by 33 publications

References 24 publications

The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation

The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation

Cellular Function and Regulation of the Translationally Controlled Tumour Protein TCTP

A translationally controlled tumor protein gene Rpf41 is required for the nodulation of Robinia pseudoacacia

Contact Info

Product

Resources

About