The transplantation donation process in the Centro de Investigaciones Medico Quirurgicas of Cuba: 1999–2002

Abdo, Anselmo; Ugarte, J.C; Castellanos, Roberto; González, Lourdes Gallardo; Lopez, Otto Guillen; Valdivia, Juan Rommel Medina; Almora, Ernesto Delgado; Suárez, Olga Pomier; Díaz, Juan Carlos Meneu; Collera, S.A.; Enamorado, Antonio; Vázquez, Antonio Baldellou; Benı́te, P; Domínguez, Juan M.; Wilford, M; Falcón, Jacob Vömel

doi:10.1016/s0041-1345(03)00696-1

Cited by 4 publications

(2 citation statements)

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“…However, our studied case had a personal history of bone marrow transplantation because of chronic myeloid leukaemia and he was on a prednisone regime. Interestingly, leukopenia has also been documented in CMV infections in transplant recipients [16] and it is probable that the presence of this opportunistic virus is associated with the white blood cell picture detected in the patient described here. Therefore, the altered antiviral immune response found in this immunosuppressed individual might be involved in the evolution of the septic complications and fatal outcome.…”

Section: Discussionmentioning

confidence: 53%

“…A number of viruses cause increased morbidity and mortality in transplant patients [14][15][16][17]; for example, we recently described the first report of herpes simplex virus and Norwegian scabies in a fatal renal transplant recipient [18]. To protect transplant patients, the American Society of Transplantation (AST) Infectious Diseases Community of Practice and the Transplant Infectious Diseases section of The Transplantation Society (TTS) developed a guidance document for S-OIV in solid organ transplantation recipients [19].…”

Section: Discussionmentioning

confidence: 99%

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Fatal 2009 pandemic influenza A (H1N1) in a bone marrow transplant recipient

Abdo¹,

Alfonso²,

Díaz³

et al. 2010

J Infect Dev Ctries

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Conditions characterized by immunosuppression have been recently reported as risk factors for severe novel swine-origin influenza A (H1N1) virus (S-OIV) infection during the current 2009 pandemic. We report clinical and virological findings, antiviral therapy, and postmortem study of S-OIV in an adult bone marrow transplant recipient. The viral genome was amplified by real time reverse transcriptase polymerase chain reaction (RT-PCR) from a nasopharyngeal swab specimen. The patient developed acute respiratory distress syndrome, septic shock, and eventually succumbed with a severe pulmonary haemorrhage. To the best of our knowledge, the entire clinical/therapy management and pathological examination in a transplant recipient infected with the S-OIV has not been previously documented. The fatal ending in this bone marrow transplant recipient supports recommendations that call for education measures, S-OIV vaccination, early diagnosis and aggressive treatment in the transplant population.

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Section: Discussionmentioning

confidence: 53%