The triggering role of physical injury in the onset of peripheral arthritis in seronegative spondyloarthropathy

Olivieri, Ignazio; Gemignani, G; Christou, C; Semeria, R.; Giustarini, S.; Pasero, G

doi:10.1007/bf02274888

Cited by 9 publications

(2 citation statements)

References 19 publications

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“…[34,35]. The autoimmune stimulus could be exposure to autogenous antigens, or by the release of antibody fragments resulting from trauma as suggested in rheumatoid arthritis or human leucocyte antigen (HLA) B27‐positive arthritis [36,37]. Schwartz [34] describes that the injured CNS can benefit from an autoimmune process, possibly intended to counteract the toxicity induced by cell components released by tissue damage, by recruiting assistance from T cells in the immune system in a way which is neuroprotective.…”

Section: Discussionmentioning

confidence: 99%

Tryptophan metabolism and oxidative stress in patients with chronic brain injury

Mackay

Forrest

Stoy³

et al. 2006

Euro J of Neurology

112

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The kynurenine pathway generates the excitotoxic N-methyl-d-aspartate receptor agonist, quinolinic acid and the glutamate antagonist, kynurenic acid, as well as free-radical generators. We investigated the status of the pathway following severe brain injury sustained at least 1 year previously in 15 patients compared with controls. At baseline, patients with brain injury showed increased levels of neopterin, erythrocyte sedimentation rate, C-reactive protein and peroxidation products in the blood compared with controls, indicating persistent inflammation and oxidative stress. At baseline and following tryptophan depletion, more tryptophan was converted to kynurenine in patients than controls, but less kynurenine was converted into the neuroprotectant, kynurenic acid. This suggests that neuroprotection by kynurenic acid may be inadequate in brain-damaged patients even many years after injury. On tryptophan loading, patients metabolized more kynurenine into kynurenic acid than controls, a process which may be neuroprotective. In addition, lower levels of 3-hydroxykynurenine and 3-hydroxyanthranilic acid in patients after tryptophan loading should be protective since these compounds generate free radicals. The results suggest that for brain-damaged patients, increased activation of the kynurenine pathway, oxidative stress and raised levels of inflammation continue many years after the original insult, possibly contributing to the continuing cerebral dysfunction in these patients.

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Section: Discussionmentioning

confidence: 99%

Tryptophan metabolism and oxidative stress in patients with chronic brain injury

Mackay

Forrest

Stoy³

et al. 2006

Euro J of Neurology

112

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“…In conclusione, il nostro caso clinico, caratterizza-to da una calcificazione-ossificazione del LLA, può con ogni probabilità far parte di quel gruppo eterogeneo di manifestazioni osteo-articolari, flogistiche e non, che riconoscono un momento scatenante di tipo traumatico (8).…”

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Diffuse post-traumatic calcification of the anterior longitudinal ligamentum of cervical and dorsal spine

Manzini¹,

Spina²,

Mascia³

et al. 2011

Reumatismo

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Among the different conditions causing flogosis and calcification/ossification of the soft tissues of the spinal cord, single or recurrent traumatic events are included. Within the international literature, the involvement of the posterior longitudinal ligament, following spinal cord injuries is frequently reported, especially in the elders. The Authors describe here an uncommon calcification/ossification of the anterior longitudinal ligament occurred after a double traumatic event in a young man, followed clinically and radiologically for a long-term period. On the basis of clinical, bioumoral and radiological findings, the differential diagnosis with other possible aetiologies, especially DISH (Diffuse idiopathic skeletal hyperostosis) and ankylosing spondylitis, is discussed

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Periphere Arthritis

Brezinschek¹

Morbus Bechterew

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The triggering role of physical injury in the onset of peripheral arthritis in seronegative spondyloarthropathy

Cited by 9 publications

References 19 publications

Tryptophan metabolism and oxidative stress in patients with chronic brain injury

Tryptophan metabolism and oxidative stress in patients with chronic brain injury

Diffuse post-traumatic calcification of the anterior longitudinal ligamentum of cervical and dorsal spine

Periphere Arthritis

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