The triphibious warfare against viruses

Liu, William J.; Liu, Di

doi:10.1007/s11427-017-9252-y

Cited by 9 publications

(8 citation statements)

References 18 publications

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“…Genomic sequencing has played a crucial role in the prevention and control of viral infectious disease [30,31]. In this study, we sequenced 114 complete genomes of DENV1-4 from 2013 to 2017 and it provided a huge support for the research of dengue fever in Guangdong, China.…”

Section: Discussionmentioning

confidence: 99%

Genomic epidemiological characteristics of dengue fever in Guangdong province, China from 2013 to 2017

Sun

Zhang

et al. 2020

PLoS Negl Trop Dis

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Dengue fever, a mosquito-borne viral disease in humans, has been endemic in many Southeast Asian countries. Since its first outbreak in 1978 in Foshan, Guangdong province, China, dengue has been continually epidemic in recent years in Guangdong, which raised the concern whether dengue infection is endemic in Guangdong. In this study, we performed phylogenetic, recombinant, and nucleotide variation analyses of 114 complete genome sequences of dengue virus serotypes 1-4 (DENV1-4) collected from 2013 to 2017 in 18 of 21 cities of Guangdong. Phylogenetic analyses revealed that DENV sequences did not form a single cluster, indicating that dengue fever was not endemic in Guangdong, although DENV1-4 co-circulated in Guangdong. Twenty intra-serotype recombinant isolates involving DENV1-4 were detected, but no inter-serotype recombinant events were identified in this study. Additionally, the most recombinant events were detected simultaneously in the gene NS3 of DENV1-4. Nucleotide variation analyses showed that no significant intra-serotype differences were observed, whereas more significant inter-subtype differences were discovered in non-structural genes than in structural genes. Our investigation will facilitate the understanding of the current prevalent status of dengue fever in Guangdong and contribute to designing more effective preventive and control strategies for dengue infection.

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Section: Discussionmentioning

confidence: 99%

Genomic epidemiological characteristics of dengue fever in Guangdong province, China from 2013 to 2017

Sun

Zhang

et al. 2020

PLoS Negl Trop Dis

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“…In recent years, emerging and re-emerging viral diseases with high mortality have continuously posed serious threats to human health [1–3]. In etiologic studies with convincing evidence, a series of such fatal diseases in humans have been confirmed or hypothesized to be caused by bat-borne viruses such as Hendra virus (HeV), Ebola virus (EBOV), Marburg virus, and coronaviruses, including severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) [4–10].…”

Section: Introductionmentioning

confidence: 99%

Peptide presentation by bat MHC class I provides new insight into the antiviral immunity of bats

et al. 2019

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Bats harbor many zoonotic viruses, including highly pathogenic viruses of humans and other mammals, but they are typically asymptomatic in bats. To further understand the antiviral immunity of bats, we screened and identified a series of bat major histocompatibility complex (MHC) I Ptal-N*01:01–binding peptides derived from four different bat-borne viruses, i.e., Hendra virus (HeV), Ebola virus (EBOV), Middle East respiratory syndrome coronavirus (MERS-CoV), and H17N10 influenza-like virus. The structures of Ptal-N*01:01 display unusual peptide presentation features in that the bat-specific 3–amino acid (aa) insertion enables the tight “surface anchoring” of the P1-Asp in pocket A of bat MHC I. As the classical primary anchoring positions, the B and F pockets of Ptal-N*01:01 also show unconventional conformations, which contribute to unusual peptide motifs and distinct peptide presentation. Notably, the features of bat MHC I may be shared by MHC I from various marsupials. Our study sheds light on bat adaptive immunity and may benefit future vaccine development against bat-borne viruses of high impact on humans.

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“…With the accelerated development of biotechnology and the continuous threats from emerging and re-emerging infectious diseases, LB should receive much more attention [8]. Administrative staff at all levels of management and laboratory technical personnel must raise their awareness and enhance their sense of responsibility.…”

Section: Perspectivesmentioning

confidence: 99%

Laboratory biosafety in China: past, present, and future

Wu¹

2019

Biosafety and Health

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The launch of the new journal, Biosafety and Health, presents me with a unique opportunity to recount the progress of laboratory biosafety (LB) in China and my contribution to this area over the past 30 years. Since the severe acute respiratory syndrome epidemic in 2003, China has constructed a primary network of high-level biosafety laboratories at different levels and established an expert team on LB. Furthermore, a series of LB management documents, including laws, regulations, standards, and guidelines, have been developed and published. This gradually maturing LB system has played a pivotal role in emerging infectious disease control and prevention, as well as in research, which in turn contributes to public health. In recent years, international collaboration between China and other countries has also been accelerated. Despite these achievements, we are still facing many challenges and opportunities in the field of LB. Sustainable LB development requires the joint efforts of the entire society and continuous international cooperation to safeguard global public health.

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The triphibious warfare against viruses

Cited by 9 publications

References 18 publications

Genomic epidemiological characteristics of dengue fever in Guangdong province, China from 2013 to 2017

Genomic epidemiological characteristics of dengue fever in Guangdong province, China from 2013 to 2017

Peptide presentation by bat MHC class I provides new insight into the antiviral immunity of bats

Laboratory biosafety in China: past, present, and future

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