2020
DOI: 10.3389/fcell.2020.573747
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The Two-Way Relationship Between Calcium and Metabolism in Cancer

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Cited by 43 publications
(31 citation statements)
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References 140 publications
(154 reference statements)
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“…The differences in elemental accumulation between healthy and neoplastic tissues are observed in the case of various types of tumors [ 23 , 24 , 25 , 26 ]. They may result, among others, from an increased demand for some elements during the tumor development, which may, in turn, be associated with the changed metabolism of tumor cells or their higher proliferation ability [ 27 , 28 , 29 , 30 ]. With knowledge of the elemental abnormalities that are characteristic for a particular neoplasm, some elements or their inhibitors might be selected and then tested as potential agents supporting the treatment against the tumor [ 31 , 32 , 33 ].…”
Section: Discussionmentioning
confidence: 99%
“…The differences in elemental accumulation between healthy and neoplastic tissues are observed in the case of various types of tumors [ 23 , 24 , 25 , 26 ]. They may result, among others, from an increased demand for some elements during the tumor development, which may, in turn, be associated with the changed metabolism of tumor cells or their higher proliferation ability [ 27 , 28 , 29 , 30 ]. With knowledge of the elemental abnormalities that are characteristic for a particular neoplasm, some elements or their inhibitors might be selected and then tested as potential agents supporting the treatment against the tumor [ 31 , 32 , 33 ].…”
Section: Discussionmentioning
confidence: 99%
“…In AsPC-1 cells, only the supra-therapeutic concentration, 100 nM, induced a significant increase in intracellular calcium with 12% (unpublished data) [ 51 ]. An increase in the intracellular Ca 2+ concentrations affects cell metabolism, proliferation, and apoptosis in cancer cells [ 52 , 53 ]. The four cell lines used in this study had major differences in their basal phenotype, which seemed to affect and dictate the response to digitoxin treatment.…”
Section: Discussionmentioning
confidence: 99%
“…For instance, the gene NOX4 , the main source of reactive oxygen species (ROS), is highly expressed in adipocytes and is controlled by gene CLTC , which was detected as significantly associated with fat accumulation in our whole-genome scan ( Den Hartigh et al, 2017 ). Our enrichment analysis detected calcium transport terms that are known to be affected by ROS in the form of impaired calcium homeostasis that can lead to cell death ( Dejos et al, 2020 ). Other adipose-related inflammation responses were also detected is this work.…”
Section: Discussionmentioning
confidence: 99%