The U-Shaped Association between Sleep Duration, All-Cause Mortality and Cardiovascular Risk in a Hispanic/Latino Clinically Based Cohort

Abstract

Sleep is essential for life, and inappropriate sleep duration patterns may lead to chronic consequences regarding human health. Several studies have confirmed the presence of a U-shaped association between sleep duration and mortality. Moreover, many consequences related to cardiometabolic aspects have been suggested in patients with abnormal sleep durations. In this study, we analyzed the associations between sleep duration, total sleep time (TST), the risk of all-cause mortality, and 10-year cardiovascular risk in a cohort of patients at a sleep medicine center in Santiago, Chile. We conducted a prospective cohort study of patients (SantOSA). A short TST was defined as ≤6 h, a normal TST as 6 to 9 h, and a long TST as ≥9 h. Adjusted hazard ratios (aHRs) for all-cause mortality were calculated. A cross-sectional analysis between TST and 10-year cardiovascular risk (calculated using the Framingham 2008 formula) was determined using logistic regression models. A total of 1385 subjects were included in the results (78% male; median age: 53, interquartile range (IQR): 42–64 years; median BMI: 29.5, IQR: 16.7–33.1). A total of 333 subjects (24%) reported short TSTs, 938 (67.7%) reported normal TSTs, and 114 (8.3%) reported long TSTs. In the fully adjusted model, the association remained significant for short (aHR: 2.51 (1.48–4.25); p-value = 0.01) and long TSTs (aHR: 3.97 (1.53–10.29); p-value = 0.04). Finally, a U-shaped association was found between short and long TSTs, with an increase in cardiovascular risk at 10 years. Compared with normal TSTs, short (≤6 h) and long (≥9 h) TSTs were significantly associated with all-cause mortality and increased 10-year cardiovascular risk.

Sleep Disruption in a Mouse Model of Chronic Traumatic Brain Injury

“…[6][7][8][9] SWD are known to contribute to morbidity and long-term health consequences and delay and impair TBI recovery; however, the underlying mechanisms are not well understood. [10][11][12][13][14][15] While it is well recognized that TBI early in life is strongly associated with chronic SWD in patients, long-term preclinical models and studies are lacking. [16][17][18] Lifelong SWD in mouse models has been understudied.…”

“…6–9 SWD are known to contribute to morbidity and long-term health consequences and delay and impair TBI recovery; however, the underlying mechanisms are not well understood. 10–15…”