The ubiquitin system: A role in disease?

Pallarés-Trujillo, J.; Agell, Neus; Garcı́a-Martı́nez, Cèlia; López‐Soriano, Francisco J.; Argilés, Josep Μ.

doi:10.1002/(sici)1098-1128(199703)17:2<139::aid-med1>3.0.co;2-0

Cited by 8 publications

(2 citation statements)

References 133 publications

(175 reference statements)

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“…This pathway plays a primary role in the degradation of short-lived regulatory or abnormal proteins (9). Recently, it has been proposed that the increased muscle protein degradation occurring in several pathological states may result from an upregulation of the ATP-Ub-dependent pathway (30). In particular, clinical studies have confirmed the involvement of this proteolytic system in the skeletal muscle catabolism that characterizes severe wasting syndromes such as sepsis, trauma, and AIDS (23,24,27,37).…”

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confidence: 99%

Increased muscle ubiquitin mRNA levels in gastric cancer patients

Bossola

Muscaritoli

Costelli

et al. 2001

American Journal of Physiology-Regulatory, Integrative and Comp

122

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The intramuscular ATP-dependent ubiquitin (Ub)-proteasome proteolytic system is hyperactivated in experimental cancer cachexia. The present study aimed at verifying whether the expression of the muscle Ub mRNA is altered in patients with cancer. Total muscle RNA was extracted using the guanidinium isothiocyanate/phenol/chloroform method from rectus abdominis biopsies obtained intraoperatively from 20 gastric cancer (GC) patients and 10 subjects with benign abdominal diseases (CON) undergoing surgery. Ub mRNA levels were measured by northern blot analysis. Serum soluble tumor necrosis factor receptor (sTNFR) was measured by ELISA. Ub mRNA levels (arbitrary units, means +/- SD) were 2,345 +/- 195 in GC and 1,162 +/- 132 in CON (P = 0.0005). Ub mRNA levels directly correlated with disease stage (r = 0.608, P = 0.005), being 1,945 +/- 786 in stages I and II, 2,480 +/- 650 in stage III, and 3,799 +/- 66 in stage IV. Ub mRNA and sTNFR did not correlate with age and nutritional parameters. This study confirms experimental data indicating an overexpression of muscle Ub mRNA in cancer cachexia. Lack of correlation with nutritional status suggests that Ub activation in human cancer is an early feature that precedes any clinical sign of cachexia.

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confidence: 99%

Increased muscle ubiquitin mRNA levels in gastric cancer patients

Bossola

Muscaritoli

Costelli

et al. 2001

American Journal of Physiology-Regulatory, Integrative and Comp

122

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“…1998). Recent studies have reported that some E3 are associated with muscular dystrophies (Pallares‐Trujillo et al . 1997; Acharyya et al .…”

Section: Resultsmentioning

confidence: 99%

Pinpointing the candidate region for muscular dystrophy in chickens with an abnormal muscle gene

Matsumoto

Maruse

Yoshizawa

et al. 2007

Animal Science Journal

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Muscular dystrophies, a group of inherited diseases with the progressive weakness and degeneration of skeletal muscle, contain genetically variable diseases. Though chicken muscular dystrophy with abnormal muscle (AM) has long been known, the gene responsible has not yet been identified. In this study, a resource family for AM was established with 487 F2 individuals and 22 gene markers, including microsatellite and insertion-deletion markers, were developed. The haplotypes were analyzed with these markers for the candidate region of GGA2q described in a previous study. The candidate region was successfully narrowed down to approximately 1Mbp. The region included seven functional genes predicted as the most likely AM candidates.

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