The ultrastructure of the Harderian gland of the mouse with particular reference to the formation of its secretory product

Woodhouse, M. A.; Rhodin, Johannes A.G.

doi:10.1016/s0022-5320(63)80037-4

Cited by 74 publications

(47 citation statements)

References 17 publications

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“…Limiting membranes were not found associated with the perimeter of the vacuoles (lipid droplets) and their outlines were often irregular, appear ing as ragger edges. This cell type corresponded to the type A cell described by Woodhouse and Rhodin [ 1963]. The other cell type without lipid droplets appeared to be undifferentiated cells such as found in the glands of 4-dayold mice.…”

Section: Resultssupporting

confidence: 73%

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Electron-Microscopic Studies on the Maturation of Secretory Cells in the Mouse Harderian Gland

Shirama¹,

Hokano²

1991

Cells Tissues Organs

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The porphyrins in the Harderian glands of mice are first detectable at 7–8 days of age in both sexes. Thereafter, the levels show a marked rise during the closed-eye period, reaching a peak around the time of eyelid disjunction and then decrease gradually until day 25. At onset of puberty, the level rises again and exhibits a sexual dimorphism. The development of the Harderian gland was examined by light and electron microscopy in the mouse. Although two types of secretory cells, designated as type A and type B, comprise the glandular epithelium in fully developed glands, the time of neonatal appearance is different between the two. Type A cells first appear on the 5th day of age while type B cells appear around the 7th day corresponding to the time at which porphyrins are first detected. Results of the investigations suggest that the porphyrins in the Harderian gland of mice may be synthesized mainly by type B cells.

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Section: Resultssupporting

confidence: 73%

“…Porphyrins normally deposit as solid accretions within the lumina of the glandu lar tubules in some rodents [rat: Grafflin. 1942: mouse: Woodhouse and Rhodin. 1963;hamster: Christensen and Dam, 1953;gerbil: Johnston et al.…”

Section: Introductionmentioning

confidence: 99%

Electron-Microscopic Studies on the Maturation of Secretory Cells in the Mouse Harderian Gland

Shirama¹,

Hokano²

1991

Cells Tissues Organs

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“…Exocytotic figures of the Harderian glands have been repeatedly reported (Abe et al, 1980;Brownscheidle and Niewenhuis, 1978;L6pez et al, 1992Sakai, 1989;Sakai and Yohro, 1981;Satoh et al, 1990Satoh et al, , 1993Strum and Shear, 1982;Watanabe, 1980;Woodhouse and Rhodin, 1963;Wooding, 1980). Interestingly, researchers reported the exocytotic figures in Harderian glands in unstimulated conditions (Fig.…”

Section: Secretory Mechanismmentioning

confidence: 63%

Lipid secretory mechanisms in the mammalian Harderian gland

Satoh

Gesase

Habara

et al. 1996

Microsc. Res. Tech.

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“…The release of granules, together with cellular debris and some pycnotic nuclei in the lumina, suggests a holocrine type of secretion. This phenomenon was rarely observed in the HG of euthyroid animals in which merocrine secretion is prevalent (Woodhouse and Rhodin, 1963;Abe et al, 1980;Sakai, 1981;Satoh et al, 1992). Hence, the decreased weight of the HG in the hypothyroid condition could be ascribed to the massive release of glandular secretion.…”

Section: Discussionmentioning

confidence: 93%

Morphological and biochemical changes in the Harderian gland of hypothyroid rats

Monteforte

Santillo

Lanni

et al. 2008

Journal of Experimental Biology

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SUMMARYThe secretory activity of the Harderian gland (HG) is influenced by both exogenous (such as light and temperature) and endogenous (such as prolactin, thyroid hormones and steroid hormones) factors, which vary among species. In the present study, the effects of hypothyroidism on the rat HG were examined at morphological and biochemical levels. The decrease in cytoplasmic lipoproteic vacuoles and the increase in mucosubstance secretion in the acinar lumina were the most notable histological effects elicited by hypothyroidism. The release of all granules with nuclei and cellular debris suggested the occurrence of holocrine secretion. Electron microscopy revealed in the glandular cells of hypothyroid rat an increased condensation of chromatin in the nuclei, mitochondria with decreased cristae and vacuolisation, decreased glycogen granules, autophagic vacuoles, and lipofuscins in the cytoplasm. TUNEL reaction indicated DNA fragmentation in hypothyroid HG, indicative of an underlying apoptotic process. Translocation of cytochrome c from mitochondria to cytosol strongly supported this hypothesis. In conclusion, these findings indicate that thyroid hormones play a pivotal role in preserving the structural integrity of the rat HG and, hence, its secretory activity.

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The ultrastructure of the Harderian gland of the mouse with particular reference to the formation of its secretory product

Cited by 74 publications

References 17 publications

Electron-Microscopic Studies on the Maturation of Secretory Cells in the Mouse Harderian Gland

Electron-Microscopic Studies on the Maturation of Secretory Cells in the Mouse Harderian Gland

Lipid secretory mechanisms in the mammalian Harderian gland

Morphological and biochemical changes in the Harderian gland of hypothyroid rats

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