The updates on metastatic mechanism and treatment of colorectal cancer

Ni, Yunfei; Liang, You; Li, Mingzhou; Lin, Yang; Zou, Xin; Han, Fangyi; Cao, Jianing; Li, Liang

doi:10.1016/j.prp.2023.154837

Cited by 5 publications

(3 citation statements)

References 124 publications

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“…Prospective clinical trials targeting GITs tend to include patients with an ECOG score of 0–1, while patients with an ECOG score of ≥2 are rarely able to participate in prospective clinical trials related to immunotherapy. 24 , 25 Differently, 12 patients (67%) with ECOG score ≥2 are being employed in our trial to explore the effectiveness and security of HIT. All patients had metastases with TNM staging IV and received at least three lines of treatments.…”

Section: Discussionmentioning

confidence: 99%

Water‐filtered infrared A radiation hyperthermia combined with immunotherapy for advanced gastrointestinal tumours

Liu,

Wu,

Chen

et al. 2024

Cancer Medicine

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IntroductionThis study aimed to validate the effectiveness, safety and feasibility of water‐filtered infrared A radiation (WIRA) whole‐body hyperthermia combined with immune checkpoint inhibitor (ICI) therapy (HIT) and evaluate the real‐world clinical application prospects.MethodsThis open‐label single‐arm phase 2 clinical trial (NCT06022692) aimed to enrol advanced gastrointestinal tumour (GIT) patients with the MSS/pMMR phenotype. The patients were treated with whole‐body hyperthermia on Days 1 and 8 of each HIT cycle along with administration of tislelizumab on Day 2.ResultsBetween 1 June 2020 and 31 May 2022, 18 patients were enrolled in the study, including those with gastric cancer (n = 6), colon cancer (n = 7), rectal cancer (n = 3) and appendiceal cancer (n = 2). As of 19 May 2023, 17 of the 18 patients had died, including 14 deaths caused by tumour progression and three deaths caused by diseases other than cancer, while one patient was still undergoing follow‐up. In terms of efficacy, the median DCR was 55.6%, while the median PFS and OS were 53.5 days and 134 days, respectively. Four patients (22.2%) experienced immune‐related adverse events, and none of the patients reported grade 3 or higher irAEs. Hyperthermia was followed by an increase in the number of tumour immune‐activated cells.ConclusionsHIT can provide survival benefits in patients with GITs by activating antitumour immune function and shows good safety and feasibility.

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Section: Discussionmentioning

confidence: 99%

Water‐filtered infrared A radiation hyperthermia combined with immunotherapy for advanced gastrointestinal tumours

Liu,

Wu,

Chen

et al. 2024

Cancer Medicine

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“…Over the past few years, there has been a decrease in the overall prevalence of CRC, but the occurrence and fatality rates among patients under 50 years old are rising [2,3]. In patients with CRC, metastasis remains the primary cause of death, whereas CRC recurrence is predominantly attributed to residual tumor cells that had metastasized to distant organs before surgery [4]. Addressing the synchronization and metachronous recurrence in distant organs is the main challenge in the treatment of CRC [5].…”

Section: Introductionmentioning

confidence: 99%

Hawthorn Proanthocyanidin Extract Inhibits Colorectal Carcinoma Metastasis by Targeting the Epithelial-Mesenchymal Transition Process and Wnt/β-Catenin Signaling Pathway

Wang,

Sun,

et al. 2024

Foods

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Colorectal carcinoma (CRC) is a major global health concern, with cancer metastasis being the main cause of patient mortality, and current CRC treatments are challenged by drug resistance. Although natural compounds, especially in foods like hawthorn proanthocyanidin extract (HPOE), have good anticancer activity, their effects on CRC metastasis remain unknown. Therefore, our objective was to investigate the impact and potential mechanisms of HPOE on the movement and infiltration of cells in the HCT116 CRC cells. Firstly, scratch-healing experiments confirmed the anti-migratory and anti-invasive capabilities of HPOE. Then, network pharmacology identified 16 possible targets, including MMP-9. Subsequently, RT-qPCR and Western blotting experiments confirmed that HPOE downregulated epithelial-mesenchymal transition-related factors (N-cadherin and MMP-9) and inhibited Wnt/β-catenin pathway activation. Finally, these results were experimentally validated using the Wnt pathway activator Licl and inhibitor XAV939. It was confirmed that HPOE had a certain inhibitory effect on the activation of the Wnt signaling pathway caused by the activator Licl and could enhance the inhibitory effect of the inhibitor XAV939. Our findings provide a basis for developing functional foods or dietary supplements, especially positioning HPOE as a functional food raw material for adjuvant treatment of CRC, given its ability to inhibit metastasis through the Wnt/β-catenin pathway.

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“…This last process being termed colonization. 7 , 8 Importantly, interactions between tumor cells and non-tumor stromal cells play a crucial role throughout the invasion-metastasis cascade. Exosome-mediated intercellular communication plays a crucial role in various critical steps of metastatic colorectal cancer (mCRC) development and progression, including enhancing tumor cell invasion and migration capacity, altering vascular permeability, facilitating immune escape, and promoting pre-metastatic niche formation.…”

Section: Introductionmentioning

confidence: 99%

Function and mechanism of exosomes derived from different cells as communication mediators in colorectal cancer metastasis

Yimin E,

Lu,

Zhu

et al. 2024

iScience

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The updates on metastatic mechanism and treatment of colorectal cancer

Cited by 5 publications

References 124 publications

Water‐filtered infrared A radiation hyperthermia combined with immunotherapy for advanced gastrointestinal tumours

Water‐filtered infrared A radiation hyperthermia combined with immunotherapy for advanced gastrointestinal tumours

Hawthorn Proanthocyanidin Extract Inhibits Colorectal Carcinoma Metastasis by Targeting the Epithelial-Mesenchymal Transition Process and Wnt/β-Catenin Signaling Pathway

Function and mechanism of exosomes derived from different cells as communication mediators in colorectal cancer metastasis

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