The Use of a “Modified Globin” from Human Erythrocytes as a Plasma Substitute

Distribution and Fate of Intravenously Administered Modified Human Globin and Its Effect on Blood Volume. Studies Utilizing I131 Tagged Globin 1

“…Modified human globin' was iodinated with a mixture of I" and I' at pH 8.0 according to the method of Pressman and Eisen (9) and then dialyzed against frequently changed 1 Reviewed in the Veterans Administration and published with the approval of the Chief Medical Director. The statements and conclusions published by the authors are the results of their own study and do not necessarily reflect the opinion or policy of the Veterans Administration.…”

“…Globin, derived from human red blood cells, has been suggested for this purpose (1,2). While considerable study with this substance is being pursued in various laboratories (1)(2)(3)(4)(5)(6)(7), there have been few published reports dealing with its use as a blood volume expander (1).…”

Nutritive Adequacy and Clinical Tolerance of Modified Human Globin 1

“…Nevertheless, the duration of action of globin may be sufficient to warrant its use as a plasma volume expander in the management of emergency situations. For example, globin has been used in the treatment of postoperative shock and shock accompanying hemorrhage or burns (2,6,7).…”

“…Modification 8 (1) of this protein renders it suitable for intravenous use. Previous studies suggest that this material may have osmotic properties useful in treating shock and may be a source of protein for parenteral administration (2)(3)(4)(5)(6)(7). The present investigation was designed to elucidate further the usefulness of modified human globin with particular regard to its nutritive value and clinical tolerance in man.…”

Dix ans d’expérience des transfusions sélectives de globules rouges

“…Certains auteurs cependant [5] Les anémies post-hémorragiques [7,8,12,23,59,63,99] : des hémorragies aigues dès que l'hémodilution est terminée et la protidémie normale (tandis qu'au stade initial le sang total s'impose au prorata du sang perdu) ; des hémorragies chroniques tant que la protidémie reste normale. Les anémies de diverses hémopathies: processus hémolytiques, leucoses, aplasies médullaires, réticuloses [69,70,71].…”