The use of Complementary and Alternative Medicines (CAMs) in the treatment of diabetes mellitus: is continued use safe and effective?

Medagama, Arjuna; Bandara, Ruwanthi

doi:10.1186/1475-2891-13-102

Cited by 110 publications

(95 citation statements)

References 55 publications

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“…It is safe within a dosage range of 1 to 6 g daily (Medagama and Bandara, 2014). No major reactions have been reported with doses of less than 6 g per day.…”

Section: Introductionmentioning

confidence: 97%

Cinnamon bark water-infusion as an in-vitro inhibitor of -hematin formation

Attieh¹,

Lafi²,

Jaber³

et al. 2015

J. Med. Plants Res.

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Malaria remains one of the prominent public health problems that lead to severe morbidity and mortality in many developing countries around the globe. New antimalarial drugs are urgently needed due to the emergence of antimalarial-resistant strains of Plasmodium falciparum. In previous studies, we tested several plants extracts that are capable of inhibiting β-hematin formation, with efficiency similar to chloroquine. In the current study, the effect of cinnamon ethanol and water extracts on inhibiting β-hematin formation was studied. Powdered cinnamon extracts and bark in a stick form were investigated using various extraction methods. A semi-quantitative in vitro method, based on the inhibition of ferriprotoporphyrin IX (FP) bio-crystallization developed by Deharo et al. (2002) was utilized. Water extracts of cinnamon revealed potential activity even at low concentration of infusions, which was manifested by a high capability to inhibit β-hematin formation in vitro.

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“…It is safe within a dosage range of 1 to 6 g daily (Medagama and Bandara, 2014). No major reactions have been reported with doses of less than 6 g per day.…”

Section: Introductionmentioning

confidence: 97%

Cinnamon bark water-infusion as an in-vitro inhibitor of -hematin formation

Attieh¹,

Lafi²,

Jaber³

et al. 2015

J. Med. Plants Res.

View full text Add to dashboard Cite

show abstract

“…Integration of complementary and alternative medicines (CAMs) with modern medicine can offer promising holistic disease management strategies for various life style disorders. A global trend of opting for CAMs along with modern medicines is also emerging as a strategy to combat various life style diseases like diabetes . Ayurveda, an Indian traditional medicine, uses several herbal formulations for diabetes management and many of them are well documented for their clinical efficacies .…”

Section: Introductionmentioning

confidence: 99%

An Ayurvedic Anti‐Diabetic Formulation Made fromCurcuma longaL. andEmblica officinalisL. Inhibits α‐Amylase, α‐Glucosidase, and Starch Digestion, In Vitro

et al. 2018

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Targeting digestive enzymes and controlling postprandial glycemia is an important approach in diabetes management. Dietary supplements that inhibit digestive enzymes are a promising strategy for managing hyperglycemia in diabetic and borderline patients, particularly those who consume high carbohydrate diets. The Indian traditional Ayurvedic system of medicine has lot to offer in this direction. The emerging trend of opting for complementary and alternative medicines for the management of life style diseases, like diabetes, is encouraging but has limited global acceptance due to inadequate information on their therapeutic efficacy and mode of action. The present work demonstrates Nisha‐Amalaki (CE), an Ayurvedic anti‐diabetic formulation prepared from Curcuma longa and Emblica officinalis, as a potential of digestive enzyme inhibitor using in vitro models. The benefit of using honey as an adjuvant for CE is also studied. A simulated in vitro digestion model adopted in the work facilitates the study of the formulation in total than its individual components. While CE inhibits α‐amylase (65%), α‐glucosidase (93%) and reduces starch digestion (≈60%), addition of honey (CEH) is found to improve α‐amylase inhibition to 107% with a higher inhibition of starch digestion. Bioassay guided fractionation of CE and CEH shows multiple fractions, a curcuminoid rich chloroform fraction and an aqueous fraction, possibly contributing to the observed pharmacological effects. In conclusion, the study reports the herbal formulation, Nisha‐Amalaki, as an inhibitor of starch digestion as well as a potential nutraceutical dietary supplement in the management of hyperglycemia.

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“…Natural substances, extracted from medicinal plants, are reliable sources of procurement of medicines and the original foundation in development of pharmaceutical compounds (Ntie-Kang et al, 2013). Herbal drugs have a better general compliance due to low adverse effects (Medagama and Bandara, 2014;Shayganni et al, 2016). Parasitic diseases infecting humans are important and serious health problems that result in significant effects on individuals and great economic and social costs (Akhoundi et al, 2013;Belkaid et al, 2002;Conceicao et al, 2016;Gutierrez et al, 2016;Mahmoudi et al, 2013;Petitdidier et al, 2016;Sacks and Perkins, 1984;Soares et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Concise review: Medicinal plants are effective against leishmaniasis

et al. 2017

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Leishmaniasis is an important zoonotic parasitic disease in tropical areas. It is a neglected disease and is a great health catastrophe in Iran. Pentavalent antimony compounds are used for its treatment, but they have adverse effects. Therefore, the use of natural herbs with low adverse effects seems necessary for treatment of Leishmaniasis. In this study, we tried to introduce the natural medicines effective against Leishmaniasis. In this review study, keywords searched included natural medicines, herbal medicines, medicinal plants, Leishmaniasis, and treatment in relevant publications published between 1990 and 2017. Searching was on databases including ISI Web of Science, PubMed, PubMed Central, Scopus, ISC, SID, Magiran and some other databases. The relevant articles were reviewed for the review study. The results showed that medicinal plants: Ferula assafoatida (with IC50 of 0.38 mg/ml), Glycyrrhiza glabra (with IC50 of 25mg/ml), Allium sativum (with IC50 of 0.57 mg/ml), Cephalis ipecacuana (with IC50 of 0.01 mg/ml), Artemisia aucheri (with IC50 of 0.46 mg/ml) and Eucalyptus globulus (with IC50 of 0.17 mg/ml) were the natural medicines effective against the disease. Compositions with di-, tri-,

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The use of Complementary and Alternative Medicines (CAMs) in the treatment of diabetes mellitus: is continued use safe and effective?

Cited by 110 publications

References 55 publications

Cinnamon bark water-infusion as an in-vitro inhibitor of -hematin formation

Cinnamon bark water-infusion as an in-vitro inhibitor of -hematin formation

An Ayurvedic Anti‐Diabetic Formulation Made fromCurcuma longaL. andEmblica officinalisL. Inhibits α‐Amylase, α‐Glucosidase, and Starch Digestion, In Vitro

Concise review: Medicinal plants are effective against leishmaniasis

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