The use of gentamicin‐impregnated collagen sponges (Garacol<sup>®</sup>/Duracoll<sup>®</sup>) in cochlear implant infections: our experience in four cases

Buijs, E.F.M.; Theunisse, H.J.; Mulder, Jef J. S.; Hoogen, F.J.A. van den; Offeciers, Erwin; Zarowski, Andrzej; Mylanus, E.A.M.

doi:10.1111/coa.12417

Cited by 8 publications

(4 citation statements)

References 11 publications

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“…[313] Collagen sponges loaded with recombinant human bone mor phogenetic protein 12 have been used successfully in rotator cuff surgery. [314] Gentamicin, Cefaclor or Ranalexin loaded col lagen sponges have been used successfully in diabetic foot, [315] cochlear, [316] sternal, [317] abdominal, [318] thoracic [319] and car diac [320] infections. A collagen/gelatin/basic fibroblast growth factor has shown promise in chronic skin ulcers treatment.…”

Section: Freeze-dried Spongesmentioning

confidence: 99%

The Collagen Suprafamily: From Biosynthesis to Advanced Biomaterial Development

et al. 2018

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Collagen is the oldest and most abundant extracellular matrix protein that has found many applications in food, cosmetic, pharmaceutical, and biomedical industries. First, an overview of the family of collagens and their respective structures, conformation, and biosynthesis is provided. The advances and shortfalls of various collagen preparations (e.g., mammalian/marine extracted collagen, cell‐produced collagens, recombinant collagens, and collagen‐like peptides) and crosslinking technologies (e.g., chemical, physical, and biological) are then critically discussed. Subsequently, an array of structural, thermal, mechanical, biochemical, and biological assays is examined, which are developed to analyze and characterize collagenous structures. Lastly, a comprehensive review is provided on how advances in engineering, chemistry, and biology have enabled the development of bioactive, 3D structures (e.g., tissue grafts, biomaterials, cell‐assembled tissue equivalents) that closely imitate native supramolecular assemblies and have the capacity to deliver in a localized and sustained manner viable cell populations and/or bioactive/therapeutic molecules. Clearly, collagens have a long history in both evolution and biotechnology and continue to offer both challenges and exciting opportunities in regenerative medicine as nature's biomaterial of choice.

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Section: Freeze-dried Spongesmentioning

confidence: 99%

The Collagen Suprafamily: From Biosynthesis to Advanced Biomaterial Development

et al. 2018

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“…In all cases, any visible biofilm was mechanically removed, and gentamicin-impregnated collagen sheets were used to obtain a higher antibiotic concentration directly in the tissue surrounding the implant. 13,14 In the first patient, the Bonebridge had been implanted in the retro-auricular region using a classic pre-sigmoid approach. After oral antibiotic treatment, surgical debridement was performed, and a rotational skin flap was needed to close the defect (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Cervicofacial surgery and implantable hearing device extrusion: management of challenging cases

et al. 2021

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Objective To describe our management of implantable hearing device extrusion in cases of previous cervicofacial surgery. Methods A review was conducted of a retrospectively acquired database of surgical procedures for implantable hearing devices performed at our department between January 2011 and December 2019. Cases of device extrusion and previous cervicofacial surgery are included. Medical and surgical management is discussed. Results Four cases of implant extrusion following cervicofacial surgery were identified: one involving a Bonebridge system and three involving cochlear implants. In all cases, antibiotic treatment was administered and surgical debridement performed. The same Bonebridge system was implanted in the middle fossa. The three cochlear implants were removed, and new devices were implanted in a more posterior region. Conclusion Previous cervicofacial surgery is a risk factor for hearing implant extrusion. The middle fossa approach is the best option for the Bonebridge system. Regarding the cochlear implant, it is always suitable to place it in a more posterior area. An inferiorly based fascio-muscular flap may be a good option to reduce the risk of extrusion.

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“…However, this is not a common practice, and the validity of its benefits is debatable. There are few case reports as mentioned by Buijs et al 22 in their report of 4 cases in which salvage surgery using gentamicin sponges was found to prevent device explantation in severe soft tissue infection.…”

Section: Discussionmentioning

confidence: 99%

Duration of Antibiotic Prophylaxis for Cochlear Implantation: A Systematic Review

Kajal¹,

Mishra²,

Gupta³

et al. 2022

Int Adv Otol

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Antibiotic prophylaxis is commonly given to all patients undergoing cochlear implant surgery. However, currently, there is no consensus if prophylactic usage of antibiotics in cochlear implantation accords any benefit and if the duration of such use varies according to the surgeon’s experience or institutional preference. A systematic review was conducted to gather evidence on ideal duration for antibiotic prophylaxis recommended for patients undergoing cochlear implantation. We registered the protocol in the International Prospective Register of Systematic Reviews (CRD42021235079) and reported the systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis statement. Of the 278 screened articles, 6 full-text original articles satisfied the inclusion criteria and were included. There were a total of 2081 participants in these 6 retrospective studies and all studies except 1 included both adult and pediatric populations. Antibiotic therapy was given as intervention, either as single dose or multiple doses, and compared with other group(s) receiving either no antibiotic prophylaxis or a different duration of prophylaxis. Three studies did not find any significant difference between infection rates when a different duration of antibiotic prophylaxis was given, while 2 studies found a single dose to be more efficacious, and yet another study concluded that a longer duration of antibiotic prophylaxis was more beneficial. Based on the available data, the ideal duration of post-operative antibiotic therapy to be given after cochlear implant surgery could not be defined. However, administrating a single dose of intraoperative antibiotic seems to be the most consistent practice so far.

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The use of gentamicin‐impregnated collagen sponges (Garacol^®/Duracoll^®) in cochlear implant infections: our experience in four cases

Cited by 8 publications

References 11 publications

The Collagen Suprafamily: From Biosynthesis to Advanced Biomaterial Development

The Collagen Suprafamily: From Biosynthesis to Advanced Biomaterial Development

Cervicofacial surgery and implantable hearing device extrusion: management of challenging cases

Duration of Antibiotic Prophylaxis for Cochlear Implantation: A Systematic Review

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The use of gentamicin‐impregnated collagen sponges (Garacol®/Duracoll®) in cochlear implant infections: our experience in four cases

Cited by 8 publications

References 11 publications

The Collagen Suprafamily: From Biosynthesis to Advanced Biomaterial Development

The Collagen Suprafamily: From Biosynthesis to Advanced Biomaterial Development

Cervicofacial surgery and implantable hearing device extrusion: management of challenging cases

Duration of Antibiotic Prophylaxis for Cochlear Implantation: A Systematic Review

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The use of gentamicin‐impregnated collagen sponges (Garacol^®/Duracoll^®) in cochlear implant infections: our experience in four cases