The Use of Matriderm® for Scalp Full-Thickness Defects Reconstruction: A Case Series

Orabona, Giovanni Dell’Aversana; Maffìa, Francesco; Audino, Giovanni; Abbate, Vincenzo; Germano, Cristiana; Bonavolontà, Paola; Romano, Antonio; Villari, Riccardo; Mormile, Mauro; Califano, Luigi

doi:10.3390/jcm11206041

Cited by 7 publications

(7 citation statements)

References 14 publications

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“…These skin substitutes act as direct source of collagen for fibroblasts, promoting neovascularization and cell migration. 8 Treating dog bites requires a meticulous initial cleaning to reduce bacterial load and infection risks, followed by appropriate coverage. Contrary to historical practices, recent studies support primary closure for dog bites with thorough cleaning, demonstrating minimal infection rates.…”

Section: Discussionmentioning

confidence: 99%

Skin graft on a collagen and elastin matrix fixed with negative pressure in a complicated pediatric dog bite: case report

Fattel-Servin,

Guevara-Valmaña,

Trigueiros-Guzmán

et al. 2024

Int Surg J

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Animal bites represent a significant source of morbidity in the pediatric population, with dogs being the primary cause. Highlighting the need for innovative solutions to effectively tackle the issue and enhance both functional and aesthetic outcomes. Dog bites, marked by a heightened morbidity rate, present an inherent infection risk owing to the considerable bacterial load present in saliva. The fundamental approach to treatment revolves around preventing infection through meticulous washing, debridement, and the timely implementation of early primary closure. We detail the management of a pediatric patient with a dog bite on the pelvic limb, resulting in a challenging-to-manage wound. This case was successfully treated with a skin graft on a bed of collagen matrix, secured with negative pressure therapy. The choice of the appropriate technique for reconstructing skin defects depends on their depth and size. Consequently, combining these three techniques yielded a favorable functional and aesthetic outcome for the patient. This case report emphasizes the relevance of employing different techniques in managing complicated dog bites.

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Section: Discussionmentioning

confidence: 99%

Skin graft on a collagen and elastin matrix fixed with negative pressure in a complicated pediatric dog bite: case report

Fattel-Servin,

Guevara-Valmaña,

Trigueiros-Guzmán

et al. 2024

Int Surg J

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“…A variety of dermal alternatives have been described for the coverage of scalp wounds. Integra ® (LifeScience Corp., Plainsboro, NJ, USA) and Matriderm (Dr Suwelack Skin and Health Care AG, Billerbeck, Germany) were first use in burn patients but their application was later expanded to reconstructive surgery in relation to chronic wounds [ 14 , 15 ]. Integra ® is a bilaminate synthetic construct consisting of an outer silicone layer and a porous inner collagen–glycosaminoglycan (chondroitin-6-sulfate) matrix.…”

Section: Discussionmentioning

confidence: 99%

Dermal Substitutes and Skin Grafts in the Reconstruction of Post-Traumatic Total Scalp Avulsion: A Case Series

Petrocelli

Togo

Ricci

et al. 2023

JCM

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Although scalp defects can vary in size and thickness, scalp avulsion represents a rare occurrence. This type of lesion may have different origins, but it is usually related to long hair being caught in agricultural machinery. The management of full-thickness scalp defects poses a challenge to the head and neck surgeon due to the possible involvement of neurovascular structures and scar retraction, which can affect the esthetic restoration of the area. Several algorithms for the choice of scalp reconstruction have been proposed in the literature and different techniques are available for extensive scalp defect reconstruction (local soft tissue flap, microvascular free flap, and skin graft combined with dermal substitutes), based upon the scalp defect type. Here we describe six cases of patients with total scalp avulsion, which required a combined reconstruction with a split-thickness skin graft (STSG) and Integra® matrix immediately after the trauma.

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“…The wounds healed, and a reduction in scarring, improved blood supply and adequate skin pigmentation were observed during follow-up visits. However, alopecia was observed in patients at the reconstruction site [92].…”

Section: Class II Skin Substitutesmentioning

confidence: 94%

Bioengineering Skin Substitutes for Wound Management—Perspectives and Challenges

Kondej,

Zawrzykraj,

Czerwiec

et al. 2024

IJMS

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Non-healing wounds and skin losses constitute significant challenges for modern medicine and pharmacology. Conventional methods of wound treatment are effective in basic healthcare; however, they are insufficient in managing chronic wound and large skin defects, so novel, alternative methods of therapy are sought. Among the potentially innovative procedures, the use of skin substitutes may be a promising therapeutic method. Skin substitutes are a heterogeneous group of materials that are used to heal and close wounds and temporarily or permanently fulfill the functions of the skin. Classification can be based on the structure or type (biological and synthetic). Simple constructs (class I) have been widely researched over the years, and can be used in burns and ulcers. More complex substitutes (class II and III) are still studied, but these may be utilized in patients with deep skin defects. In addition, 3D bioprinting is a rapidly developing method used to create advanced skin constructs and their appendages. The aforementioned therapies represent an opportunity for treating patients with diabetic foot ulcers or deep skin burns. Despite these significant developments, further clinical trials are needed to allow the use skin substitutes in the personalized treatment of chronic wounds.

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The Use of Matriderm® for Scalp Full-Thickness Defects Reconstruction: A Case Series

Cited by 7 publications

References 14 publications

Skin graft on a collagen and elastin matrix fixed with negative pressure in a complicated pediatric dog bite: case report

Skin graft on a collagen and elastin matrix fixed with negative pressure in a complicated pediatric dog bite: case report

Dermal Substitutes and Skin Grafts in the Reconstruction of Post-Traumatic Total Scalp Avulsion: A Case Series

Bioengineering Skin Substitutes for Wound Management—Perspectives and Challenges

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