The use of novel ionic liquid‐in‐water microemulsion without the addition of organic solvents in a capillary electrophoretic system

Abstract

In this work, a new ionic liquid-in-water (IL/W) microemulsion without requiring toxic organic solvents was investigated as a pseudostationary phase (PSP) in CE. As observed during the IL/W microemulsion system, a fast and an efficient separation of eight phenolic acids was achieved using 1-butyl-3-methylimidazolivmhexa fluorophosphate (bmimPF(6)) as oil drops, Tween 20 as the surfactant, and borate as the BGE. The effects of oil phase, surfactant, buffer and pH on the separation were explored in detail to evaluate the novel PSP. In contrast, the detection efficiency of these same analytes was markedly decreased using oil-in-water (O/W) MEEKC. We have also validated the practicality of the IL/W microemulsion method by quantitative determination of acidic compounds in pharmaceutical injection. The results obtained indicated that an additional association between the IL cations and analytes tested seemed to play a prominent role in the separation mechanism exhibited by this novel PSP compared with the conventional O/W MEEKC.

The use of ionic liquid as a mobile phase modifier in analytical supercritical fluid chromatography for the separation of flavonoids

“…Entirely the ultraviolet absorption of ILs used in present study were all less than 240 nm (see ESI †, Fig. S1), consisting with the previous reports 17 . Since the maximal absorbance of flavonoids were at 260 nm and/or in the range between 330 and 360 nm (see ESI †, Fig.…”

Development of Novel Ionic Liquid-Based Microemulsion Formulation for Dermal Delivery of 5-Fluorouracil

“…MEs are thermodynamically stable isotropic mixtures of polar, nonpolar, and amphiphilic phase, which provide unique advantages like nanosized aggregates, pharmacodynamic stability, enhanced drug solubilization, and ease of preparation (10,11). Depending on the polarity, ILs can be employed to prepare ionic liquid in oil (IL/ o) (12,13) or ionic liquid in water (14,15) type of MEs.…”

The Activity-Integrated Method for Quality Assessment of Reduning Injection by On-Line DPPH-CE-DAD

“…Although these analytical methods prevented interference from color pigments of analytes, they often involved usage of large amount of organic reagents which were considered harmful to environment. As a powerful analytical technique, capillary electrophoresis (CE) has gained much attention in separation science [13], since it owned the advantages such as simple preparation process, short analysis time, excellent efficiency and few organic reagents. Capillary electrophoresis with the Diode Array Detector (CE-DAD) method has been used to separate components and successfully applied to quality control of herbal medicines [14]–[16].…”