This article is devoted to an actual research problem in conditions of increased uncertainty and the need for a theoretical rethinking of the tourism phenomenon in the society, when geopolitical upheavals and a decrease in international security are taking place, as well as the pandemic COVID-19, which currently poses new challenges for the tourism industry. Today, it is more relevant and appropriate than ever to think about them from the perspective of blockchain technology, using a fundamental approach to the digitalization of decentralized management of the life cycle of an internal regional tourism product. It is required to develop an integrated scientific and methodological approach to modeling and designing cyber-physical systems for monitoring and managing tourism products, objects, and processes based on blockchain technologies in order to maximize the contribution of the tourism industry to the socioeconomic development of regions.