The Utility of Exercise Testing after Cardiac Transplantation in Older Patients

Chang, Andrew C.; Shyr, Yu; Groves, Jay; Chomsky, Don; Davis, Stacy F.; Wilson, John R.; Drinkwater, Davis C.; Pierson, Richard N.; Merrill, Walter H.

doi:10.1006/jsre.1998.5484

Cited by 5 publications

(1 citation statement)

References 20 publications

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“…Our study documented that also VO 2peak measured after HTx is a strong predictor for long-term survival[ 17 ], and this result is in line with the only study we found that demonstrated a relationship between physical performance (measured by VE/VCO 2 slope) and survival in a small sample of HTx patients ( n = 49)[ 18 ]. Other related studies on this topic describe how VO 2peak is related to soft end-points; how a beneficial VO 2peak correlates with NYHA class 1-2 after HTx[ 19 ] and how the pre-transplant VO 2peak, together with age, predict the gain in physical capacity post HTx[ 5 ]. Succeeding our study on survival, Rosenbaum et al[ 20 ] published new knowledge in this field, with a study investigating the effect of early rehabilitation on survival: They concluded that early cardiac rehabilitation participation after HTx could predict survival time.…”

Section: Introductionmentioning

confidence: 99%

Importance of physical capacity and the effects of exercise in heart transplant recipients

Yardley¹,

Gullestad²,

Nytrøen³

2018

WJT

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One of the most important prognostic factors in heart failure patients is physical capacity. Patients with very poor physical performance and otherwise eligible, may be listed as candidates for heart transplantation (HTx). After such surgery, life-long immunosuppression therapy is needed to prevent rejection of the new heart. The dark side of immunosuppression is the increased risk of infections, kidney failure, cancer and advanced atherosclerosis (cardiac allograft vasculopathy), with the two latter conditions as the main causes of later mortality. In a worldwide perspective, 50% of the HTx patients survive past 10 years. Poor aerobic capacity prior to graft deterioration is not only limited to the failing heart, but also caused by peripheral factors, such as limited function in the skeletal muscles and in the blood vessels walls. Exercise rehabilitation after HTx is of major importance in order to improve physical capacity and prognosis. Effects of high-intensity interval training (HIT) in HTx recipients is a growing field of research attracting worldwide focus and interest. Accumulating evidence has shown that HIT is safe and efficient in maintenance HTx recipients; with superior effects on physical capacity compared to conventional moderate exercise. This article generates further evidence to the field by summarizing results from a decade of research performed at our center supported by a broad, but not strict formal, literature review. In short, this article demonstrates a strong association between physical capacity measured after HTx and long-term survival. It describes the possible “HIT-effect” with increased levels of inflammatory mediators of angiogenesis. It also describes long-term effects of HIT; showing a positive effect in development of anxiety symptoms despite that the improved physical capacity was not sustained, due to downregulation of exercise and intensity. Finally, our results are linked to the ongoing HITTS study, which investigates safety and efficiency of HIT in de novo HTx recipients. Together with previous results, this study may have the potential to change existing guidelines and contribute to a better prognosis for the HTx population as a whole.

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Section: Introductionmentioning

confidence: 99%

Importance of physical capacity and the effects of exercise in heart transplant recipients

Yardley¹,

Gullestad²,

Nytrøen³

2018

WJT

View full text Add to dashboard Cite

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366: Patterns and predictors of physical functional disability at 5-10 years after heart transplantation

Grady

Naftel

Young

et al. 2007

The Journal of Heart and Lung Transplantation

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Patterns and Predictors of Physical Functional Disability at 5 to 10 Years After Heart Transplantation

Grady¹,

Naftel²,

Young³

et al. 2007

The Journal of Heart and Lung Transplantation

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Corresponding author and reprint requests: Kathleen L. Grady, PhD, RN, APN, FAAN, Bluhm Cardiovascular Institute, Division of Cardiac Surgery, 201 East Huron Street, Chicago, Telephone: (312) Fax: (312) 695-3910. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Background-Researchers have not examined relationships between perception of physical functional disability and demographic, clinical, and psychological variables at 5-10 years after heart transplantation. Therefore, the purposes of this study were to describe physical functional disability over time and identify predictors of physical functional disability from 5 to 10 years after heart transplantation. NIH Public Access

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The Utility of Exercise Testing after Cardiac Transplantation in Older Patients

Cited by 5 publications

References 20 publications

Importance of physical capacity and the effects of exercise in heart transplant recipients

Importance of physical capacity and the effects of exercise in heart transplant recipients

366: Patterns and predictors of physical functional disability at 5-10 years after heart transplantation

Patterns and Predictors of Physical Functional Disability at 5 to 10 Years After Heart Transplantation

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