The utility of thermal analysis in the preformulation and development of an antifungal nail lacquer containing thymol

Cunha-Filho, Marcílio; Simões, Devana F.; Pires, Felipe Q.; Rocha, Jessika L.; Freire, Daniel; Silva, Izabel C. R.; Barreto, Lívia Cristina Lira de Sá

doi:10.1007/s10973-020-09984-2

Cited by 5 publications

(2 citation statements)

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“…Thus, the oligomer is considered a suitable and safe nail improvement strategy for antifungal transungunal delivery ( Chouhan and Saini, 2014 ). HP-β-CD complexation was used to improve the physical stability of thymol, a highly volatile antifungal molecule, and increase its retention in the film ( Cunha-Filho et al., 2021 ). Similar lacquers were developed in sulfur, silicon, and biotin supplements to treat nail inflammatory disorders ( Fernandez-Campos et al., 2020 ).…”

Section: Polymer-based Strategies In Fungal Disease Treatmentmentioning

confidence: 99%

“…Eudragit E, an acidic-water-soluble acrylic resin, was used to form a film with citric acid and glycerin as plasticizers. The presence of citric acid reduces local pH and increases the aqueous solubility of the polymeric matrix ( Cunha-Filho et al., 2021 ).The stability of the formula at room temperature is a critical factor for easier application because patients may skip treatment if the lacquer has to be refrigerated.…”

Section: Polymer-based Strategies In Fungal Disease Treatmentmentioning

confidence: 99%

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Progress of polymer-based strategies in fungal disease management: Designed for different roles

Guo

et al. 2023

Front. Cell. Infect. Microbiol.

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Fungal diseases have posed a great challenge to global health, but have fewer solutions compared to bacterial and viral infections. Development and application of new treatment modalities for fungi are limited by their inherent essential properties as eukaryotes. The microorganism identification and drug sensitivity analyze are limited by their proliferation rates. Moreover, there are currently no vaccines for prevention. Polymer science and related interdisciplinary technologies have revolutionized the field of fungal disease management. To date, numerous advanced polymer-based systems have been developed for management of fungal diseases, including prevention, diagnosis, treatment and monitoring. In this review, we provide an overview of current needs and advances in polymer-based strategies against fungal diseases. We high light various treatment modalities. Delivery systems of antifungal drugs, systems based on polymers’ innate antifungal activities, and photodynamic therapies each follow their own mechanisms and unique design clues. We also discuss various prevention strategies including immunization and antifungal medical devices, and further describe point-of-care testing platforms as futuristic diagnostic and monitoring tools. The broad application of polymer-based strategies for both public and personal health management is prospected and integrated systems have become a promising direction. However, there is a gap between experimental studies and clinical translation. In future, well-designed in vivo trials should be conducted to reveal the underlying mechanisms and explore the efficacy as well as biosafety of polymer-based products.

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Section: Polymer-based Strategies In Fungal Disease Treatmentmentioning

confidence: 99%

Section: Polymer-based Strategies In Fungal Disease Treatmentmentioning

confidence: 99%