The vacuole controls nucleolar dynamics and micronucleophagy via the NVJ

Tasnin, Most Naoshia; Takuma, Tsuneyuki; Sharmin, Tasnuva; Morshed, Shamsul; Ushimaru, Takashi

doi:10.1016/j.bbrc.2021.02.141

Cited by 8 publications

(3 citation statements)

References 25 publications

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“…Thus, it may be more accurate to portray PMN and nucleophagy as two sides of the same coin, as they act redundantly to degrade similar sets of proteins, lipids, and nucleic acids. Consistent with this idea, the inhibition of both PMN and nucleophagy results in a synthetic loss of fitness in the context of nitrogen starvation (Tasnin et al, 2021). Although PMN has not yet been discovered in metazoans, there are examples of lysosomes in contact with the nucleus (Park et al, 2009;Mutvei et al, 2020).…”

Section: Piecemeal Microautophagy Of the Nucleusmentioning

confidence: 81%

Quality control mechanisms that protect nuclear envelope identity and function

Mannino¹,

Lusk²

2022

Journal of Cell Biology

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The nuclear envelope (NE) is a specialization of the endoplasmic reticulum with distinct biochemistry that defines inner and outer membranes connected at a pore membrane that houses nuclear pore complexes (NPCs). Quality control mechanisms that maintain the physical integrity and biochemical identity of these membranes are critical to ensure that the NE acts as a selective barrier that also contributes to genome stability and metabolism. As the proteome of the NE is highly integrated, it is challenging to turn over by conventional ubiquitin-proteasome and autophagy mechanisms. Further, removal of entire sections of the NE requires elaborate membrane remodeling that is poorly understood. Nonetheless, recent work has made inroads into discovering specializations of cellular degradative machineries tailored to meeting the unique challenges imposed by the NE. In addition, cells have evolved mechanisms to surveil and repair the NE barrier to protect against the deleterious effects of a breach in NE integrity, in the form of either a ruptured NE or a dysfunctional NPC. Here, we synthesize the most recent work exploring NE quality control mechanisms across eukaryotes.

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Section: Piecemeal Microautophagy Of the Nucleusmentioning

confidence: 81%

Quality control mechanisms that protect nuclear envelope identity and function

Mannino¹,

Lusk²

2022

Journal of Cell Biology

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“…These findings suggest Mdm1 and Nvj2 play a specific role in neutral lipid synthesis and LD dynamics. Different studies have shown a role of NVJ proteins in regulating nucleolar dynamics [44,45]. Furthermore, it is noteworthy that Cvm1, a yeast protein that forms NVJ and vCLAMP, is required for sphingolipid homeostasis [46].…”

Section: Discussionmentioning

confidence: 99%

Vacuole membrane contact sites regulate liquid‐ordered domain formation during glucose starvation

et al. 2023

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Liquid‐ordered (Lo) membrane domains have been proposed to play important roles in a wide variety of biological processes, such as protein sorting and cell signaling. However, the mechanisms by which they are formed and maintained remain poorly understood. Lo domains are formed in the vacuolar membrane of yeast in response to glucose starvation. Here, we show that the deletion of proteins that localize to vacuole membrane contact sites (MCSs) caused a marked decrease in the number of cells with Lo domains. In addition to Lo domain formation, autophagy is induced upon glucose starvation. However, the deletion of core autophagy proteins did not inhibit Lo domain formation. Thus, we propose that vacuolar Lo domain formation during glucose restriction is regulated by MCSs but not by autophagy.

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“…Interestingly, micronucleophagy also appears in some cases to require Atg39 and the core autophagy machinery since the deletion of these proteins blocks autophagic degradation of nucleus-vacuole junction proteins such as Osh1 and Nvj1 [43]. However, this depends on the cargo monitored since not every cargo is strictly dependent on these proteins [44]. It is unclear what role the core autophagy machinery proteins play in micronucleophagy [38][39][40].…”

Section: Selective Autophagy Of Nuclear Components In S Cerevisiaementioning

confidence: 99%

Autophagy as a caretaker of nuclear integrity

Boyle,

Wilfling

2023

FEBS Letters

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Due to their essential functions, dysregulation of nuclear pore complexes (NPCs) is strongly associated with numerous human diseases, including neurodegeneration and cancer[1]. On a cellular level, longevity of scaffold nucleoporins in post‐mitotic cells of both C. elegans and mammals renders them vulnerable to age‐related damage, which is associated with an increase in pore leakiness and accumulation of intranuclear aggregates in rat brain cells[2–4]. Thus, understanding the mechanisms which underpin the homeostasis of this complex, as well as other nuclear proteins, is essential. In this review, autophagy‐mediated degradation pathways governing nuclear components in yeast will be discussed, with a particular focus on NPCs. Furthermore, the various nuclear degradation mechanisms identified thus far in diverse eukaryotes will also be highlighted.This article is protected by copyright. All rights reserved.

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The vacuole controls nucleolar dynamics and micronucleophagy via the NVJ

Cited by 8 publications

References 25 publications

Quality control mechanisms that protect nuclear envelope identity and function

Quality control mechanisms that protect nuclear envelope identity and function

Vacuole membrane contact sites regulate liquid‐ordered domain formation during glucose starvation

Autophagy as a caretaker of nuclear integrity

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