The Value of Diffusion-Weighted Imaging in Predicting the Prognosis of Stage IB-IIA Cervical Squamous Cell Carcinoma After Radical Hysterectomy

Abstract

Mean ADC was a good biomarker in predicting the prognosis of stage IB-IIA cervical SCC after radical hysterectomy.

The value of advanced MRI techniques in the assessment of cervical cancer: a review

“…As noted above, the tumour ADC can be used to assess tumour grading, which can reflect tumour aggressiveness [ 92 ] and which is associated with treatment resistance. Several authors have compared pre-treatment ADC values in patients with versus without later tumour recurrence, finding that low pre-treatment ADC values seem to be a strong predictor of later tumour recurrence [ 22 , 101 – 107 ]. Furthermore, changes in ADC values during chemotherapy, radiotherapy or chemoradiation may help evaluate the treatment response [ 42 , 43 , 108 – 123 ].…”

The association between serum squamous cell carcinoma antigen and recurrence and survival of patients with cervical squamous cell carcinoma: A systematic review and meta-analysis

“…Some studies reported probability of outcome occurrence or median survival, leaving 44 studies for final pooling of association effects. Among these 44 studies, 31 [14,15,19,21,23, and 26 [14,22,23,28,30,36,37,39,[42][43][44][45][46][47][48][50][51][52][53][54][55][56][57][58][59][60] assessed association effects of pretreatment serum SCC-Ag on recurrence and death outcomes respectively, while 8 [9,19,[23][24][25]31,61,62] and 4 [23,24,60,62] assessed posttreatment SCC-Ag effects on these corresponding outcomes.…”

“…Among 8 studies, 4 [9,23,24,61] and 3 [19,24,62] studies reported frequency data and HR, respectively; whereas 3 [19,25,31] studies compared mean SCC-Ag between recurrence groups.…”

“…Some studies assessed the predictive effects of pretreatment SCC-Ag on disease progression (i.e., recurrence or death) after receiving treatments either as an additional predictor in the presence of other previously known predictors [12,13] or by itself [14][15][16][17][18][19], as well as in monitoring the response to treatment [20]. In addition, SCC-Ag was also found to be associated with disease progression in some studies [19,[21][22][23][24][25]. Although association effects of SCC-Ag were consistent across these studies, their magnitudes were still varied.…”

Diffusion magnetic resonance imaging: A molecular imaging tool caught between hope, hype and the real world of “personalized oncology”

“…They found that the median ADC of recurrent carcinomas (1.23 ± 0.20 × 10 -3 mm 2 /s) was significantly lower than benign vault tissue (2.56 ± 0.46 × 10 -3 mm 2 /s) ( P < 0.001)[68]. Diffusion has also shown to aid in predicting prognosis, follow-up of these patients and detects metastatic disease with higher degree of accuracy[69,70]. Wang et al[71] metaanalysis showed that DWI has prognostic implications and serves as a biological marker for survival in cervical cancer.…”