The value of dynamic contrast-enhanced magnetic resonance imaging combined with apparent diffusion coefficient in the differentiation of benign and malignant diseases of the breast

Abstract

Background The value of combined dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and apparent diffusion coefficient (ADC) histogram analysis for the diagnosis of breast cancer has not been evaluated in previous studies. Purpose To investigate the diagnostic value of DCE-MRI combined with ADC in benign and malignant breast lesions. Material and Methods The clinicopathological imaging data included 168 patients (177 lesions) with breast lesions who underwent convention breast MRI, DCE-MRI, and diffusion-weighted imaging (DWI); they were divided into the benign lesion group (n = 39) and malignant lesion group (n = 129) based on pathology. Results Using the type III outflow curve as a diagnostic criterion for malignant breast lesions, the diagnostic sensitivity was 76.9%, the specificity was 80%, the correct rate was 72.2%, and its area under the curve (AUC) was 0.823. Using an enhancement ratio > 100% as a diagnostic criterion for malignant breast lesions, the sensitivity was 61.5%, specificity was 80%, and AUC was 0.723. Using > 3 ipsilateral vessels as a diagnostic criterion for malignant lesions in the breast resulted in a diagnostic sensitivity of 81.6%, a specificity of 80.8%, and an AUC of 0.805. Conclusion The type of time intensity curve DCE-MRI, the early enhancement rate in the first phase, the number of ipsilateral vessels, and the ADC full volume histogram of the blood supply score and DWI are valuable in the diagnosis of benign and malignant breast lesions.

Prediction of pathological complete response to neoadjuvant chemotherapy in patients with breast cancer using a combination of contrast‐enhanced ultrasound and dynamic contrast‐enhanced magnetic resonance imaging

“…Furthermore, Sohrab et al found that plateau and washout DCE curve types were associated with malignancy 34 . Similarly, the proportion of plateau/washout DCE curve types in the non‐pCR group was significantly higher 35,36 …”

“…34 Similarly, the proportion of plateau/washout DCE curve types in the non-pCR group was significantly higher. 35,36 Data are expressed as the mean ± standard deviation or n (%), and p < 0.1 was considered statistically significant.…”

“… 34 Similarly, the proportion of plateau/washout DCE curve types in the non‐pCR group was significantly higher. 35 , 36 …”

The utility of diffusion-weighted imaging for differentiation of phyllodes tumor from fibroadenoma and breast cancer

“…Diffusion-weighted imaging (DWI) has become clinically relevant (12,13). DWI is a non-invasive MRI technique that can measure the diffusion of water molecules across tissues, in vivo.…”

“…In this case, a bi-exponential model is necessary to measure diffusion and microperfusion parameters. ADC values may be determined in three different types of tumor regions of interest (ROIs), including a circular ROI (ROI-c), single-slice ROI (ROI-s), and whole-tumor ROI (ROI-w) (13). ADC values can provide objective and accurate quantitative information (20)(21)(22)(23)(24).…”