The value of post-neoadjuvant therapy PET-CT in the detection of interval metastases in esophageal carcinoma

Abstract

Background PET-CT scanning is increasingly applied in the primary work-up of esophageal

Impact of a second FDG PET scan before adjuvant therapy for the early detection of residual/relapsing tumours in high-risk patients with oral cavity cancer and pathological extracapsular spread

“…First, we shown that pre-RT/CCRT PET results may prompt treatment modification in as many as 24 % of highrisk OSCC patients. Recently, Blom et al showed the potential value of an additional PET scan in high-risk cancer patients before the initiation of curative treatment [18]. These authors performed an additional PET scan in oesophageal cancer patients during post-neoadjuvant therapy and before surgery to detect the presence of interval metastases.…”

PET with Fluorodeoxyglucose F 18/Computed Tomography in the Clinical Management and Patient Outcomes of Esophageal Cancer

“…Interval metastases may be detected in the liver, lungs, distant lymph nodes, and bone. 46,47 The presence of distant metastases at unusual sites, such as skeletal muscle, has also been reported. 46 Because the presence of distant metastases dramatically changes the treatment plan and some of them may be outside the visual range of routine stand-alone CT imaging, 18 F-FDG PET/CT is a preferred imaging modality of choice in this setting.…”

“…However, the number of false-positive 18 F-FDG PET/CT results for distant metastases seems to be low. 47,48 A common cause for false-positive results is inflammation or infection. False-positive results have been encountered in up to 8% of the patients.…”

“…46 Because the presence of distant metastases dramatically changes the treatment plan and some of them may be outside the visual range of routine stand-alone CT imaging, 18 F-FDG PET/CT is a preferred imaging modality of choice in this setting. 46,47 A concern of 18 F-FDG PET/CT in restaging is the possible identification of lesions that are false-positive for metastases but require further diagnostic work-up. However, the number of false-positive 18 F-FDG PET/CT results for distant metastases seems to be low.…”

Nomogram for predicting pathologically complete response after neoadjuvant chemoradiotherapy for oesophageal cancer

“…PET-CT can be used, however, to detect interval metastases [42]. Radiation causes an inflammatory reaction of the oesophagus and its surrounding tissue, thus inducing FDG-uptake with a false positive interpretation.…”