The value of “routine tests” in the staging evaluation of gynecologic malignancies: a cost effectiveness analysis

Abayomi, Olubunmi K.; Dritschilo, Anatoly; Emami, Bahman; Watring, Watson G.; Piro, Anthony J.

doi:10.1016/0360-3016(82)90520-x

Cited by 16 publications

(5 citation statements)

References 7 publications

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“…Our analysis of 188 endometrial cancer patients suggests that MSI in endometrial cancer is associated with an increased risk for abnormalities (including polyps and cancer) found on perioperative colon screening. This finding may help explain why the aforementioned retrospective studies on perioperative colon screening in unselected endometrial cancer patients (10–12) have not detected an increased rate of polyps and cancers, given that their patient cohorts were not stratified by tumor MSI status and only approximately 30% of patients with endometrial cancer have tumors exhibiting the MSI phenotype (21,22) .…”

Section: Discussionmentioning

confidence: 99%

“…In spite of many possible explanations of why endometrial cancer patients have an increased relative risk for developing colorectal cancer, several retrospective studies have failed to find higher rates of abnormalities on perioperative colon screening in patients with endometrial cancer (10–12) . The aim of this study was to determine whether molecular stratification of endometrial cancers based on tumor MSI status could help identify a subgroup of patients most at risk for preinvasive and invasive tumors of the colon.…”

mentioning

confidence: 99%

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Increased risk for abnormalities on perioperative colon screening in patients with microsatellite instability–positive endometrial carcinoma

Buttin

Powell

Goodfellow

et al. 2006

Int J Gynecol Cancer

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Microsatellite instability (MSI) is a feature of certain hereditary and sporadic endometrial and colon cancers. We set out to determine whether molecular stratification of endometrial cancers based on tumor MSI status could help identify patients at increased risk for abnormalities found on perioperative colon screening. From a prospectively accrued series of 413 patients, medical records were reviewed from 94 patients with MSI positive (MSI+) and 94 patients with MSI negative (MSI-) endometrial cancers, matched by year of diagnosis. We reviewed clinicopathologic data and results of perioperative colon screening. Differences were analyzed using Fisher exact test and logistic regression analysis. There were no significant clinicopathologic differences between the two cohorts. Sixty-five percent of patients in each group underwent perioperative colon screening. However, patients with MSI+ cancers had a twofold increase in the frequency of colonic abnormalities (30% versus 14.8%, P = 0.044) over those with MSI- cancers. Furthermore, the only primary colon cancers (N = 2) were found in women with MSI+ endometrial cancers that were unmethylated at the MLH1 promoter. Our data suggest that patients with MSI+ endometrial cancers are at increased risk for abnormalities on perioperative colon screening. Those with MSI+MLH1 unmethylated cancers appear to be at highest risk.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Increased risk for abnormalities on perioperative colon screening in patients with microsatellite instability–positive endometrial carcinoma

Buttin

Powell

Goodfellow

et al. 2006

Int J Gynecol Cancer

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show abstract

“…In den vorliegenden Studien wurde endoskopisch keine Rektuminfiltration diagnostiziert [1,12,16]. Auch bei prätherapeutisch durchgeführten Kontrastuntersuchungen des Darmes beim Endometriumkarzinom [1,12,16] oder im Vorfeld abdominaler Hysterektomien [14] wurde kein derartiger Befund erhoben. Auch in unserer Untersuchungsgruppe wurde präoperativ rektoskopisch keine Rektuminfiltration diagnostiziert, jedoch in einem Fall intraoperativ, Stadium FIGO IV, gesichert.…”

Section: Karzinombedingte Rektuminfiltrationunclassified

Zystoskopie und Rektoskopie in der präoperativen Ausbreitungsdiagnostik beim Endometriumkarzinom

Halis¹,

Pritze²,

Oehmke³

et al. 2009

Tumordiagn u Ther

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“…In den vorliegenden Studien wurde endoskopisch keine Rektuminfiltration diagnostiziert [1,12,16]. Auch bei prätherapeutisch durchgeführten Kontrastuntersuchungen des Darmes beim Endometriumkarzinom [1,12,16] Interessenkonflikt ! Der Korrespondenzautor erklärt, dass keine finanziellen Verbindungen mit einer für den Artikel relevanten Firmen vorliegen.…”

Section: Karzinombedingte Rektuminfiltrationunclassified

Zystoskopie und Rektoskopie in der präoperativen Ausbreitungsdiagnostik beim Endometriumkarzinom

Halis¹,

Pritze²,

Oehmke³

et al. 2009

Geburtsh Frauenheilk

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The value of “routine tests” in the staging evaluation of gynecologic malignancies: a cost effectiveness analysis

Cited by 16 publications

References 7 publications

Increased risk for abnormalities on perioperative colon screening in patients with microsatellite instability–positive endometrial carcinoma

Increased risk for abnormalities on perioperative colon screening in patients with microsatellite instability–positive endometrial carcinoma

Zystoskopie und Rektoskopie in der präoperativen Ausbreitungsdiagnostik beim Endometriumkarzinom

Zystoskopie und Rektoskopie in der präoperativen Ausbreitungsdiagnostik beim Endometriumkarzinom

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