The value of single versus multiple sections for detection of lymph node metastasis

Shingaki, Susumu; Ohtake, Katsuya; Nomura, Tsutomu; Nakajima, Tamio

doi:10.1016/0278-2391(91)90167-k

Cited by 16 publications

(5 citation statements)

References 7 publications

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“…Although it has been shown that serial sectioning of suspect lymph nodes yields less false negatives for metastasis compared with single sectioning, no study has shown the difference to be enough to explain the disparity of metastatic disease found in the study reported here and in the previous work. [12][13][14] Retrospective clinical studies in veterinary medicine, unlike those in human medicine, often lack a substantial number of cases that would contribute to the power and reliability of the results, as in the case of the previous study. In mathematics, the law of large numbers is a principal of probability that states the larger the sample size, the more likely it is to accurately represent the true population.…”

Section: Discussionmentioning

confidence: 99%

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Validation of Regional Lymph Node Excisional Biopsy for Staging Oral and Maxillofacial Malignant Neoplasms in 97 Dogs and 10 Cats (2006-2016)

2019

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The objective of this retrospective clinical study was to confirm the validity of excisional biopsy of regional lymphocentrums for staging oral and maxillofacial neoplasms in a population of 97 dogs and 10 cats. Patients diagnosed with oral and maxillofacial malignant neoplasms underwent ipsilateral excisional biopsy of the mandibular, parotid, and medial retropharyngeal lymphocentrums that receive afferent drainage from the oral and maxillofacial region followed by curative intent surgery of the neoplasm. Biopsy specimens and the resected neoplasm were submitted to a commercial pathology laboratory for histopathologic assessment. The incidence of metastasis to one or more regional lymphocentrums was 14.0%. Of the cases with metastatic disease, 26.7% did not involve the mandibular lymphocentrum. Although the incidence of regional lymph node metastasis was less than reported previously, regional lymph node assessment is warranted in cases of oral and maxillofacial neoplasia.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Validation of Regional Lymph Node Excisional Biopsy for Staging Oral and Maxillofacial Malignant Neoplasms in 97 Dogs and 10 Cats (2006-2016)

2019

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“…Unterschiedliche Untersuchungen in der Literatur konnten zeigen, dass durch zusätzliche semiserielle Schnitte nur in einem minimalen Prozentsatz, d. h. zwischen 0,3 und 4,2% der Fälle, zusätzlich Mikrometastasen identifiziert werden konnten [2,3].So gilt für Mikrometastasen von Plattenepithelkarzinomen im KopfHals-Bereich im Gegensatz zu Mikrometastasen von Mammakarzinomen nach wie vor das bei sorgfältiger Einbettung der Lymphknoten je ein Schnitt zur vollständigen Beurteilung in der Routinediagnostik mittels HE-Färbung ausreicht [4,5,6].Hinsichtlich der prognostischen Relevanz von Mikrometastasen existieren momentan keine prospektiven Untersuchungen.…”

Section: Mikrometastasen Und Kapselüber-schreitendes Wachstum In Halsunclassified

Workshop Sentinel Node 2003

Werner

2004

HNO

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Am 8. November 2003 richtete die Arbeitsgemeinschaft Onkologie der Deutschen Gesellschaft für Hals-, Nasen-undOhrenheilkunde, Kopf-und Halschirurgie, einen Workshop zum Thema "Sentinel Node" vor 50 Teilnehmer/-innen aus.Fragen zur Wertigkeit des Sentinel Node begründen sich in der nach wie vor aktuellen Diskussion um das optimale diagnostische und therapeutische Behandlungskonzept des klinischen N0-Halses bei Karzinomen der oberen Luft-und Speisewege. Im Zentrum der Diskussion um die Behandlung des klinischen N0-Halses steht die Frage nach dem Vorliegen klinisch okkulter Lymphknotenmetastasen, deren Inzidenz mit Werten zwischen 12 und über 50% bei einem Median von 33% angenommen wird und ganz erheblich von der Lokalisation des Primärtumors abhängt. So wird die Indikationsstellung zu einer elektiven Neck-Dissection bei den allermeisten Karzinomlokalisationen von zahlreichen Autoren befürwortet, da von einer Wahrscheinlichkeit okkulter Lymphknotenmetastasen von 20% oder mehr ausgegangen werden kann.Die Festlegung der jeweiligen Metastasierungswahrscheinlichkeit, d. h. eines individuellen Risikos, ist hierbei an verschiedene Faktoren gebunden, die bis heute noch nicht abschließend geklärt sind. Im Kontext der Bemühungen um ein einheitliches Diagnostik-und Therapieverfahren des Lymphabflusses bei Karzinomen der oberen Luft-und Speisewege galt es, im Rahmen des Workshops zum Sentinel Node, den Stellenwert dieses neuen Diagnostik-und Therapiekonzeptes bei der Lösung der Kontroverse um den klinischen N0-Hals näher zu hinterfragen.

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“…While this remains current practice in virtually all hospitals, there has been at least one study which has examined this question critically [54]. These authors found metastatic deposits in 40 of 802 cervical lymph nodes studied microscopically by examination of a single histologic section from each tissue block; serial sectioning of the putatively negative nodes revealed an additional two nodes which harbored small deposits of metastatic tumor which were missed by the initial sectioning.…”

Section: Microscopic Study Of the Cervical Node Dissection Specimenmentioning

confidence: 99%

“…At present, the added data yielded by undertaking such a heroic effort does not appear to warrant doing this routinely [54]; nonetheless, this emphasizes one truth threaded throughout all of surgical pathology practiceselection of sections for microscopic study is, of necessity, ultimately a process of sampling. Pathologists should be expected to carry out that sampling which is calculated to yield valuable information, but it should be borne in mind that this is still a sorting process -sections from one area will be studied, while sections from elsewhere will not.…”

Section: Microscopic Study Of the Cervical Node Dissection Specimenmentioning

confidence: 99%

The Pathology of Neck Dissection in Cancer of the Larynx

Devaney

Ferlito

Rinaldo

et al. 2000

ORL

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Cancer of the larynx is a common problem in a head and neck oncological surgical practice; as such, pathology departments supporting such surgical practices will examine cervical lymph node dissection specimens with some frequency. Issues to be settled among pathologists and surgeons include – How precise an anatomic dissection of the specimen is called for? What histological features of the specimen will be of most use to the clinicians who are devising a course of postoperative therapy for the patient? What sorts of methods are needed to identify the maximum number of micrometastases which may be lurking within the lymph nodes of the specimen? Is there a role for routine application of special techniques – such as immunohistochemistry or molecular biology – in the analysis of these specimens? While the answers to these questions are likely to vary somewhat from one center to another, patients are best served when these questions are discussed amongst the respective physicians before surgical procedures are undertaken, rather than after the fact.

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The value of single versus multiple sections for detection of lymph node metastasis

Cited by 16 publications

References 7 publications

Validation of Regional Lymph Node Excisional Biopsy for Staging Oral and Maxillofacial Malignant Neoplasms in 97 Dogs and 10 Cats (2006-2016)

Validation of Regional Lymph Node Excisional Biopsy for Staging Oral and Maxillofacial Malignant Neoplasms in 97 Dogs and 10 Cats (2006-2016)

Workshop Sentinel Node 2003

The Pathology of Neck Dissection in Cancer of the Larynx

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