The Value of Squamous Cell Carcinoma Antigen in the Prognostic Evaluation, Treatment Monitoring and Followup of Patients With Penile Cancer

Zhu, Yushan; Ye, Ding Wei; Yao, Xu; Zhang, Shi Lin; Dai, Bo; Zhang, Hai Liang; Shen, Yi

doi:10.1016/j.juro.2008.07.040

Cited by 38 publications

(19 citation statements)

References 16 publications

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“…Similarly, several studies have shown that SCC-Ag level, which might also serve as a sensitive marker of disease progression, is correlated with tumour burden in penile cancer [19][20][21]. In the present study, we first show the relationship between preoperative serum CRP and SCC-Ag levels in penile SCC.…”

Section: Discussionsupporting

confidence: 53%

“…An elevated CRP concentration is independently correlated with tumour load and disease progression, which is also correlated with survival in various cancers [14,15], and two recent studies have shown that CRP correlates with tumour burden in penile cancer [16,17]. Another potential prognostic marker in penile cancer is SCC antigen (SCC-Ag), a serum tumour marker used for various human SCCs [18,19], and an elevated level of SCC-Ag has been reported to be associated with clinical outcome in patients with penile cancer [19][20][21]; however, to the best of our knowledge, the relationship between CRP and SCC-Ag levels and their potential value in combination as a prognostic marker of survival in penile cancer have not been previously explored. In the present study, we retrospectively analysed 124 patients with penile SCC to evaluate the combined prognostic value of elevated CRP and SCC-Ag levels.…”

Section: Introductionmentioning

confidence: 99%

“…As an increasing number of studies have since shown the clinical significance of SCC-Ag in human cancers [18,19,[27][28][29], serum SCC-Ag level is useful for evaluating response to therapy and tumour prognosis. Univariate analysis in the present study also confirmed positive relationships between elevated SCC-Ag and ENE (P < 0.001), pathological tumour status (P = 0.001), pathological nodal status (P < 0.001; Table 2) and DSS (P < 0.001, Fig.…”

mentioning

confidence: 99%

“…Unfortunately, SCC-Ag level did not retain significance as an independent prognostic indicator of penile cancer in our multivariate analysis (Table 3; model 2). This result may be attributed to the fact that the level of SCC-Ag does not have sufficient sensitivity for the detection of tumours with a small tumour burden and has minimal prognostic significance with regard to survival after surgery [19].…”

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confidence: 99%

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Clinical significance of preoperative C‐reactive protein and squamous cell carcinoma antigen levels in patients with penile squamous cell carcinoma

Yao

et al. 2015

BJU International

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ObjectiveTo evaluate the relevance of C-reactive protein (CRP) and squamous cell carcinoma antigen (SCC-Ag) levels in relation to clinicopathological factors and prognosis in penile cancer. Patients and MethodsA total of 124 Chinese patients with penile squamous cell carcinoma (SCC), treated between November 2007 and October 2014, were analysed retrospectively. Receiveroperating characteristic curves were used to identify the combination of markers with the best sensitivity and specificity for prognosis prediction. Statistical data analysis was performed using a non-parametric method, and survival analysis was performed using the log-rank test and Cox proportional hazard model. ResultsLevels of CRP ≥4.5 mg/L and SCC-Ag ≥1.4 ng/mL were both significantly associated with lymph node metastasis (LNM) laterality (chi-squared trend test, P = 0.041), extranodal extension (chi-squared trend test, P < 0.001), pelvic LNM (chi-squared trend test, P = 0.024), pathological tumour status (chi-squared trend test, P = 0.002), pathological nodal status (chi-squared trend test, P < 0.001), and diseasespecific survival (DSS; log-rank test, P < 0.001). Moreover, the influence of CRP and SCC-Ag levels on DSS (P = 0.033, hazard ratio 3.390, 95% confidence interval 1.104-10.411) remained after adjusting for smoking history, phimosis, tumour status, tumour cell differentiation and nodal status. ConclusionsThe present study shows that the combined measurement of preoperative CRP and SCC-Ag levels may serve as an independent biomarker for LNM, advanced tumour stage and DSS in patients with penile SCC.

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Section: Discussionsupporting

confidence: 53%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Clinical significance of preoperative C‐reactive protein and squamous cell carcinoma antigen levels in patients with penile squamous cell carcinoma

Yao

et al. 2015

BJU International

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“…The soluble eptithelial antigen SCC lacks sensitivity in the detection of small tumor burdens and has little prognostic significance for survival after surgery [13]. The detection of lymph node metastases has been associated with the overexpression of p53 and Ki-67, as well as loss of membraneous E-cadherin, but these markers are not useful in clinical practice [2,14].…”

Section: Introductionmentioning

confidence: 99%

Elevated C-reactive protein values predict nodal metastasis in patients with penile cancer

et al. 2013

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BackgroundThe nodal status is a strong predictor for cancer specific death in patients with penile carcinoma, and the C-reactive protein (CRP) level at diagnosis has recently been shown to be associated with poor clinical outcome in various solid malignancies. Therefore, this retrospective study was performed to evaluate the association between preoperative CRP levels and the incidence of nodal metastasis in patients with squamous cell carcinoma (SCC) of the penis.MethodsThe analysis included 51 penile cancer patients who underwent either radical or partial penectomy for pT1-4 penile cancer between 1990 and 2010. The nodal status was correlated with patient and tumor specific characteristics.ResultsSixteen (31%) patients had lymph node metastasis at the time of penile cancer surgery. Nodal status was associated with tumor stage but did not correlate significantly with tumor grade. In contrast, high presurgical CRP levels were significantly associated with the diagnosis of nodal involvement (p = 0.04). The optimal CRP cut-off value to predict lymph node metastasis was set at 20 mg/l based on ROC analysis.ConclusionsSince a high preoperative serum CRP level was closely correlated with nodal disease, it could be used as an additional marker to help identify patients with penile cancer who may benefit from inguinal lymph node dissection.

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Trajectories of squamous cell carcinoma antigen and outcomes of patients with advanced penile cancer after chemotherapy based on paclitaxel, ifosfamid, and cisplatin regimen

Ma,

Gan,

Chao

et al. 2024

Cancer Medicine

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IntroductionPenile cancer (PC) is a lethal malignancy with no effective prognostic biomarker. We aim to investigate associations between trajectories of squamous cell carcinoma antigen (SCC‐A) and patient outcomes after chemotherapy based on paclitaxel, ifosfamid, and cisplatin (TIP) regimen.MethodsConsecutive AJCC staging III/IV PC patients who received TIP chemotherapy and repeated SCC‐A measurements in 2014–2022 were analyzed. Latent class growth mixed (LCGM) models were employed to characterize patients' serum SCC‐A trajectories. Patient survival, and clinical and pathological tumor responses were compared. Inverse probability treatment weighting was used to adjust confounding factors.ResultsEighty patients were included. LCGM models identified two distinct trajectories of SCC‐A: low‐stable (40%; n = 32) and high‐decline (60%; n = 48). Overall survival (HR [95% CI]: 3.60 [1.23–10.53], p = 0.019), progression‐free survival (HR [95% CI]: 11.33 [3.19–40.3], p < 0.001), objective response rate (37.5% vs. 62.5% p = 0.028), disease control rate (60.4% vs. 96.9% p < 0.00), and pathological complete response rate (21.2% vs. 51.9%, p = 0.014) were significantly worse in the high‐decline arm.ConclusionPC patients' SCC‐A change rate was associated with tumor response and patient survival after TIP chemotherapy. SCC‐A might assist tumor monitoring after systemic therapies.

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The Value of Squamous Cell Carcinoma Antigen in the Prognostic Evaluation, Treatment Monitoring and Followup of Patients With Penile Cancer

Abstract: Squamous cell carcinoma antigen is not a sensitive marker of tumor burden. However, it has prognostic significance for disease-free survival in patients with penile cancer treated with surgery.

Cited by 38 publications

References 16 publications

Clinical significance of preoperative C‐reactive protein and squamous cell carcinoma antigen levels in patients with penile squamous cell carcinoma

Clinical significance of preoperative C‐reactive protein and squamous cell carcinoma antigen levels in patients with penile squamous cell carcinoma

Elevated C-reactive protein values predict nodal metastasis in patients with penile cancer

Trajectories of squamous cell carcinoma antigen and outcomes of patients with advanced penile cancer after chemotherapy based on paclitaxel, ifosfamid, and cisplatin regimen

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