The Value of Upper Extremity, face, and uterus transplantation: A Summit Conference

Tintle, Scott M.; Shores, Jaimie T.; Azari, Kodi; Tzakis, Andreas G.; Dearden, Marissa E.; Porrett, Paige M.; Johannesson, Liza; McDiarmid, Sue V.; Pomahač, Bohdan; Levin, L. Scott

doi:10.1016/j.orthop.2022.08.008

Cited by 1 publication

(7 citation statements)

References 14 publications

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“…Thus, collaboration among the international VCA centers with consensus, longitudinal datasets is key to draw clinical conclusions beyond anecdotal data. The American Society for Reconstructive Transplantation (ASRT) was created in 2008 as a platform to advance education, science, and practice of VCA [16,31]. No standardized surgical or pharmacologic protocols for any procurement or transplant have been established, but detailed documentation of these experiences is key [25,32].…”

Section: Increasing Benefitmentioning

confidence: 99%

“…better understanding of PROs. The key question with VCA is 'what is the price for improved quality of life [31]?' One can conjecture that VCA enhances patients' lives based on some objective outcomes.…”

Section: Key Pointsmentioning

confidence: 99%

“…Perhaps most importantly for a field like VCA which predicates on enhancing quality of life, is better understanding of PROs. The key question with VCA is ‘what is the price for improved quality of life [31]?’ One can conjecture that VCA enhances patients’ lives based on some objective outcomes. Among face transplant recipients, VCA frequently eliminates the need for gastrostomies and tracheostomies, and improves oral competence and sense of smell [31].…”

Section: Improving the Risk-to-benefit Balancementioning

confidence: 99%

“…The key question with VCA is ‘what is the price for improved quality of life [31]?’ One can conjecture that VCA enhances patients’ lives based on some objective outcomes. Among face transplant recipients, VCA frequently eliminates the need for gastrostomies and tracheostomies, and improves oral competence and sense of smell [31]. Among upper extremity recipients, functional independence including driving is enhanced [31].…”

Section: Improving the Risk-to-benefit Balancementioning

confidence: 99%

“…Among face transplant recipients, VCA frequently eliminates the need for gastrostomies and tracheostomies, and improves oral competence and sense of smell [31]. Among upper extremity recipients, functional independence including driving is enhanced [31]. The recipient wait list for uterus transplant continues to grow into the thousands, reflective of its demand [31].…”

Section: Improving the Risk-to-benefit Balancementioning

confidence: 99%

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What is needed to ensure long-term sustainability for the field of vascularized composite allotransplantation?

Toyoda,

Levin

2023

Current Opinion in Organ Transplantation

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The field of vascularized composite allotransplantation (VCA) has demonstrated remarkable advances since its inception with some excellent long-term results in a variety of graft types. However, unlike solid organ transplantation, it has yet to become mainstream. We therefore discuss strategies on ensuring long-term sustainability by addressing continued clinical developments of VCA to improve the risk-to-benefit balance, importance of public support, improved policy and financial support, and need for a bridge to the future of transplant surgery. There has been headway on all fronts and collaboration among the VCA centers for centralization of data and incorporation of patient voices will be essential for continued progress.

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Section: Increasing Benefitmentioning

confidence: 99%

Section: Key Pointsmentioning

confidence: 99%